<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25826

Description KLTH0E07370p
SequenceMADKEGGEVSKGLKEFDFGNLHEKLESEDGYKDSVKQEIQSVQDSIQPMRLRFNELLNMLAIIDQETEVSNQEKFLSIRAKIVEFVSELQAFSSSYGRLQPLFDNIQQQPKGGKTSIKFTPLERLRHLSDASLGNQAKSASGGSPPAAAVASVPTTTKQPKSSTNTPTSNAATPSATFNAAAKKSRKSRSKKNSLPTGLGGHPVATAASPAAVAAAAAAVSTNPGVAMGSNPGIQQQFTPSTNPTQILSSMSPMNMMSSPMNIMSPANNVNMAYTGPTKPPVPSHRHMPSSSQQMNMNGITPANILNMSMMEQANQPHLTTAPAPQPPNQLDMNNLDLNNLDLSNLNMDFLQ
Length352
PositionTail
OrganismLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea.
Aromaticity0.04
Grand average of hydropathy-0.516
Instability index58.70
Isoelectric point8.67
Molecular weight37605.00
Publications
PubMed=19525356

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25826
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.51|      33|      33|     266|     298|       1
---------------------------------------------------------------------------
  266-  298 (63.68/28.38)	PANNVNMAYTGPTKPPVPSHRHMPSSSQQMNMN
  302-  334 (61.83/27.38)	PANILNMSMMEQANQPHLTTAPAPQPPNQLDMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     109.62|      25|      43|     152|     176|       2
---------------------------------------------------------------------------
  108-  123 (19.76/ 6.80)	...........QQPKG.G....KT.......SIKFTPLE
  124-  148 (21.55/ 8.06)	RLRHLSdaslgNQAKSaSGGS.P.............PAA
  152-  176 (42.59/22.82)	SVPTTT.....KQPKS.STNT.PT.......SNAATPSA
  180-  212 (25.72/10.99)	AAAKKS.....RKSRS.KKNSlPTglgghpvATAASPAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.58|      40|      59|       3|      46|       4
---------------------------------------------------------------------------
    3-   46 (58.06/54.61)	DKEgGEVSKGLKefdFGNLHEKL.E..SEDGYKDSVKQEIQSVQDSI
   64-  106 (58.52/40.59)	DQE.TEVSNQEK...FLSIRAKIvEfvSELQAFSSSYGRLQPLFDNI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25826 with Med3 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LSDASLGNQAKSASGGSPPAAAVASVPTTTKQPKSSTNTPTSNAATPSATFNAAAKKSRKSRSKKNSLPTGLGGHPVATAASPAAVAAAAAAVSTNPGVAMGSNPGIQQQFTPSTNPTQILSSMSPMNMMSSPMNIMSPANNVNMAYTGPTKPPVPSHRHMPSSSQQMNMNGITPANILNMSMMEQANQPHLTTAPAPQPPNQLDMNNLDLNNLDLSN
128
345










Molecular Recognition Features






MoRF SequenceStartStop




1) IKFTPLERLRHL
117
128