Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MPQPEFIQERLESLNAVDNQLLSTLLHASQAVGTIEELKRGNENMKSQFENHIRSFYGSLEEATVALRREIRHLDENVGTRLLPINVNKKAVGQDNEKMREQFEHLEHEAS |
Length | 111 |
Position | Head |
Organism | Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.756 |
Instability index | 57.80 |
Isoelectric point | 5.35 |
Molecular weight | 12794.16 |
Publications | PubMed=19525356 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP25823 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 39.52| 11| 51| 42| 53| 1 --------------------------------------------------------------------------- 42- 53 (17.64/15.26) NENMKSQFEnHI 96- 106 (21.88/13.45) NEKMREQFE.HL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 70.07| 22| 44| 13| 34| 2 --------------------------------------------------------------------------- 13- 34 (34.79/21.73) SLNAVDNQLLSTLLHASQAVGT 59- 80 (35.28/22.11) SLEEATVALRREIRHLDENVGT --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) IEELKR 2) LEEATVALRREIRHLD 3) NEKMREQFEHLEHEA 4) NVGTRLLPINVNKKAV 5) PEFIQERLES 6) QFENHIRSFYG | 35 60 96 77 4 48 | 40 75 110 92 13 58 |
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