<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25822

Description KLTH0D02376p
SequenceMEADWRTTLSNQERSKYITELAQILAQISQVNGGDRGNFNLEKLKKTAEQFEKSLYASSSSKELYLDSMRKRIAAMDTAKKKAIANIQHNAANVAAHQQSQQQAAVAAAQSAQQQRASQFPPSNMNSQMFFNQQAQVRQQAAQQFRNGVGSNMPVNSAPTRPQLTPQQQQLINEMKGAEIPRELLQRIPNLPPGVNTWQKVTELAQQKRLGPKDLQIAKQVYKMHQQIVFKSKMQQASANNRGIPQQRAMPQGPNMAQMPQPRSVVNQPLQQQQHQQQQQQQQHQQHQQQQQQQQQHQQHQQQQQQQQQHQHQQHQQQQQQQQQQRQTGQVPQPSGQEMPNVLNRLNQIFTPAEQKALYENGKKLIEDLQRTNRLPTVLTPQQQAIYIKKYINQMALKKLQAARMNQMGTTNPQQQMAPAPAPQGQSVPAMSQFTSNVAPSNANLAGMAQRRAYERANAGGASDVNSVGSSTQAQLSSGSSQQAPPAQQQPQPQPKFSLPRPTEQDLMVLRRISAEIQKSHLRLSNITNQISQEQKQAIRNKLQLNRQLFTNVDSFIPTLYMITRNEENVRQLLQIRMLAKEITEHATRGVFIVPPEVVDKVIFRYQKYYEFIKDQVLRRHQQIIAARQQQQQQQQAPSTTIDPAFNQQRIQGSFQQIQQQMQMRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQKIQPSPQLNNWTRLNADGRSTSGADGDNAVAPQTAPEHVRRSSSGMDFLNSPEFMNARSSPQQPGLSPAKKQAQMRKKMAMKQVPGQGTPGSTVPTSNNTPVPVSGPVPAVASRTGTPQVGTAGISSISPMVNRATGLNQSPSPRSHPNGTLPPPADYPYKEDEENLKKMAIRKTEIIARFKCRQEILGKSSVDLFLCSLGDCLGLPSASVDLISPIPSEIVEHVNGGCKGKNNGAPGQRVKGQDLTDVSIVNNSIVFADSNSPEAKAEPYVIGLNDVASVFRDVYGSTDLSSFSFETKTFSGEGGAKKRKAGDLDNSPDASPASSAIMSESKKLKIDSPEDMYFTAPGEDTKQLLTKSGAMKFSPENKIWDWSFWETS
Length1086
PositionTail
OrganismLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea.
Aromaticity0.05
Grand average of hydropathy-0.953
Instability index70.57
Isoelectric point9.85
Molecular weight121771.94
Publications
PubMed=19525356

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25822
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     184.08|      17|      17|     666|     682|       1
---------------------------------------------------------------------------
  273-  289 (36.09/ 8.06)	QQHQQQQQQQQHQQHQQ
  290-  305 (35.81/ 7.94)	QQQQQQQHQQHQQQ.QQ
  306-  322 (35.61/ 7.84)	QQQQHQHQQHQQQQQQQ
  664-  680 (36.65/ 8.31)	MRQQQQQQQQQQQQQQQ
  681-  697 (39.93/ 9.79)	QQQQQQQQQQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.26|      30|      30|     344|     373|       2
---------------------------------------------------------------------------
  163-  189 (26.63/ 9.91)	....QL.TPQQQQLI...........NEmKGAEIPrEL......LQRIP
  196-  238 (25.70/ 9.28)	NTWQKVTELAQQKRLgpkdlqiakqvY.....KMH.QQivfkskMQQAS
  344-  373 (51.93/27.07)	NRLNQIFTPAEQKAL...........YE.NGKKLI.ED......LQRTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.81|      21|      70|     628|     652|       4
---------------------------------------------------------------------------
  629-  652 (34.13/14.04)	QQQQQQQQ..APSTTIDpafNQQRIQ
  700-  722 (36.69/ 8.40)	QQQQQQQQkiQPSPQLN...NWTRLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     163.53|      29|      30|      93|     121|       5
---------------------------------------------------------------------------
   93-  121 (46.89/16.47)	NVAAHQQSQ......QQAAVAAAQSAQQQR...ASQFP
  124-  154 (40.76/13.16)	NMNSQMFFN......QQAQV.RQQAAQQFRngvGSNMP
  407-  435 (44.75/15.31)	QMGTTNPQQ......QMAPAPAPQGQSVPA...MSQFT
  467-  498 (31.14/ 7.99)	SVGSSTQAQlssgssQQAPPAQQQPQPQPK...FS...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.39|      23|      54|     765|     792|      10
---------------------------------------------------------------------------
  242-  259 (29.05/ 6.58)	RGIPQQRAMPQGPNMAQM...........
  381-  402 (25.43/ 7.85)	...PQQQAIYIKKYINQM....ALKklQA
  765-  791 (35.91/20.18)	RSSPQQPGLSPAKKQAQMrkkmAMK..QV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25822 with Med15 domain of Kingdom Fungi
Unable to open file!