<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25820

Description KLTH0A07106p
SequenceMPSKYLLTPPEGLHSLTSGNTKKIYPDFDPWSHTPLDDKIFLNFVSKGYYNSAKVNFESISSRSSLQESLPAVSGLLADQLSDVVRIREEKINRITANSTSSAKKSGMPSDLSGPGFSLPKRVTLTDHRRELWLQEMSSPQSSLSETSKTIPHGLKRRQLLEQCYLKQIPIPRAIWLIKCCFSLEWKTLANKQGATQIEDGIDKLLKEWSETMVHLLERLVFEMTQYYNEPVKLSNWRQKIKYYLSLLGNCYSLNLMDSNFFHHWLVDFIAKIENFEYLPMALHILTVFWGGIFEACRHSEDPQQLFLVNKMTEALLYKYYMVTSSRSMINDEQYLINDVKKNNKVNKTILAKLKGLIEKIFQGQSMEAFVFPNNNWDIYKKCLYEILQVDKIREDDGSSSEASKKLELIVYRNDSLKFNTILHDADTESLGSGNETPNNLENIFVPDTVLKLKRIDYKLTKALDENCPGDDWATFADQKLRRVEQIIQMMLWAVHPSRSHHYEASQLVAKLLLLKLNSRNGNLEYSLEDKIWALVFVFAKTKSEDLKFMVSLTRLHQLLNVFIGYGIVKVPTYIRKLISSGVLYLTHSSDKLFHCNLLINLKISPLMKIQYNMVLRNVHESNPEFYDNYNYDRLMEMLEGAKESLSSGNYEFVKEVPYSIKLMASEWYLNVICSPIDGSLRTVRKLDVIEKLKVFCVNLKVYHQFYKWVEFIVYHQLLNDLEALECLVDILMYYDKLFPLLINDHTLLMKTILHLHSLKLAPQNTASQNLLLFNDFWLFFMKRFPLALEIDTDLQTKLIEAYESEKAQIERLAKPHSRNDGTSPLKADNDSIQSVKKESQNFPSVFQPNLKCLLTSGEEESLRNARKNMRVLMIINLTEYNKFMSIFLKRRSASDEELARLISLKVLSLSLIKKVLGGPAVVNLLDTRYCDCGMAFELQKKTFTKQNLRLVMNALCEDLPGSYQKLLNVIGEFSTTKNGQEQISNIVNKVQVKGGKDTFSFITDLLNLGVNNSEWGNFEPLPESARHDLFEDDGEVTEEETDVLDLFSRLNFTNLWIFQILTSLYLQSMNCLSPAKPHFALDIIELTGCDVAASKLFDKISNVEVLEKTLQTLEVDFFQRKSIKDPEVSYYYVIIETIVNISRRLNKVSTSSIPMGEESFRLMKECCHEFISKDPTDLAKLEYRLDAFLKILIVHQKFILKEGLEKPQPAFEGYSEFLRMLCQLFHKIDFSLKLKLLLYDVLASMKSFVIYSSTGRNHQLSIKKNLKVPKELLDLPPFKISSFMPGDIPSGEANKVEPGIKDRNPSDEPRKPVFFLYNKSSNTFEEKLSLRPFHLLDNFQEEGPEFNNTPLNLCLFNASYYRKNPT
Length1367
PositionKinase
OrganismLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea.
Aromaticity0.10
Grand average of hydropathy-0.253
Instability index41.58
Isoelectric point7.01
Molecular weight157910.56
Publications
PubMed=19525356

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25820
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     625.99|     157|     177|     545|     706|       1
---------------------------------------------------------------------------
  489-  543 (37.30/15.51)	...............................................................................QMMLWAVHPSRSHHYEA...SQ.LVAKL......LLLKLNSRNGN..................LE......YS..LEDKIWALVFVF...AKTK.............................
  545-  706 (254.77/174.66)	EDLKFMVS.LTR...LHQLLNVFIGYGIVKVPTYIRK.LISSGVLYLT...HSSDKLFHCN..LLINLKISPL.MKIQYNMVLRNVHESNPEFYDNYNYDR.LMEML......EGAKESLSSGN..................YEFVKEVPYSIKLMASEWYLNVIC...SPIDGSLRTVRKldvieKLKVF.CVNLKVYHQF
  723-  884 (184.01/116.75)	EALECLVDiLMY...YDKLFPLLINDHTLLMKT.ILH.LHS...LKLApqnTASQNLLLFNdfWLFFMKRFPLaLEIDTDL........QTKLIEAYESEKaQIERLakphsrNDGTSPLKADN...................DSIQSVKKESQNFPSVFQPNLKClltSGEEESLRNARK.....NMRVLmIINLTEYNKF
  885- 1027 (149.92/92.19)	MSI.F....LKRrsaSDEELARLISLKVLSL.SLIKKvLGGPAVVNLL...DT..RYCDCG..MAFELQKKTF.TKQNLRLVMNALCEDLPG.....SYQK.LLNVI.......GEFSTTKNGQeqisnivnkvqvkggkdtFSFITDL.LNLGVNNSEWG.NF.....EPLPESAR.........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.95|      37|     182|    1046|    1084|       2
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 1046- 1084 (61.46/42.84)	DLFSRLNFT...NLWIFQILTSlyLQSMNCLSPAKPHFALDI
 1224- 1263 (57.49/33.64)	QLFHKIDFSlklKLLLYDVLAS..MKSFVIYSSTGRNHQLSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.07|      58|      71|     349|     407|       9
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  349-  407 (92.10/74.89)	TIL..AKLKGLIEKIFQGQSMEAFVFPNNNWDIyKKCLYEILQ.VDKIREDDGSSSEASKKL
  421-  481 (88.97/66.34)	TILhdADTESLGSGNETPNNLENIFVPDTVLKL.KRIDYKLTKaLDENCPGDDWATFADQKL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25820 with Med12 domain of Kingdom Fungi
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