Description | Mediator of RNA polymerase II transcription subunit 9 |
Sequence | MASSSLSNASLAQIEALLVPNAQSSGQSSEFIPQLYYALHQVKKDPNSSVNSLETATSSIRHRLKQCKSHIAESEECRALLSKTPEEWEAALRQRQKDLAVKQQVFARLERQIRDLGDH |
Length | 119 |
Position | Middle |
Organism | Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.600 |
Instability index | 66.27 |
Isoelectric point | 7.83 |
Molecular weight | 13330.82 |
Publications | PubMed=19525356 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364145 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP25819 No repeats found |
MoRF Sequence | Start | Stop |
1) KDLAVKQQV 2) MASSSLSNASLAQIEALLVPNAQSSGQSSEFIPQLYYALHQVKKDPNSSVNSLETATSSIRHRLKQCKSHIAESEECRALLSKTPEEWEAAL | 97 1 | 105 92 |
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