<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25809

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTDAWSVSNILTHYHKIGHLQSVTYAIYTVKEDAMDQYLLELELQIRHQHPHILLIYYNKSLYHFSLDEPKKYDGGESDNSAASGSSKLHSLYPQLILQHENTVAAGELANPSRVAKSAASRKKGKDDSPVDEHLAFASLSFLKAVKKCIVYSLSLSGQMQIFGNYLVARAPGSSFQKTVVQTDPILLANGDLIVSLSQRNSLKLFETSALDVPSEMADYANSFVIYVLPSGLRCHLYDTVNYEQNFTYVASKSSENLLRLLKYSMGVDLTKKKQILWAKLIPNLQHLNNQTSNISHFVHDVENKKYILWPWELCLLQFGSVEECVQTDPDPSAKDPLSLVSDFIQFSINCHNAEPALKPPVPEPIGLTDPGSVGNIPPFSIPSALSTGASTGGEETKHETQMLNQVPNIFSQDDTFFDPSDPNVGLEHKHNATEQPKSEEEDLEDLFGYSSDSDTKKNTQDEGSADGKEEDIKKEENDFKEDHEDFEQDNETENVQKSPASRDSNIQEESDVSFQVGNKQTGEESFINIPRDQMITAPFEPSTTTYDDPGAPLPIMPTPILQSTPFHSSTANTAQAKPPAEAKKGGRGLSGDGYVFSPISFNPKIRSSIDTKYGKGGKFYVAREASSGPEESRSRLRETSVYNATDLPFRREVNSSAPETEEAFSDGIERRDERGEEREGERTEPAEMQRTDRGDTMRTERGEAMRTDRGEAMRTDRGDTFDDTFHMGIEDVEDEDDEDEEEDDDEESDVDEEFSSGELRTSPLKLNTTSGDIFHWPPASAVDTQKQTQASFALGSGLLSPGQTRALGSKGESPFGTVLSDTQYLSFSPMPAAEKASSHIDTAIGDEAEKKEEAAPASGAGESTNCLPLILRSINVYSIPSRFLLRKALQWGGVALAPGFDMDVDNDDDFDSPGALSVRAAHLDEFLHWLTGNLVFSGGGRARPKRMRLCAPARMLEEAGAPQNSAPQNSAPQNSAHNKTGAGSDSVALDGEVSPEVARVFASVFPLSYQIALGEFVTESEQKPPPADDQLFLGDMGENGPGDVFWHTLAPEQQHRGGFERYRRQRLDKPSRPADDAHVFSTGDVKATVLKNDDTLNVSVVGTRLWRHLNFRPVGGPKRFQVVLISEASGGLAHDAAHDWGDAMSGFLAMLQSSFRENHLGSISPLSLQPPATRPDLEGISNGLMLVPRAPGTAYRDFYKSVDRRLWALAELVKLDLINKTRRFDFGRPLLVLFVSFDQSLAQASQHAKLCRNLRSFLSDHRLAVVELFSHVVAGDQVVRQSRARRRLRYLSAGALARLSLALYDKCPARDTRAARLHTHLVRAPPETLALRWAATAGRESFHDGVFLHVAYERSVDKRWICAAWSDPLGLATGVRSWFCPRDGTGHSLEHVIGALWTEASASLRRLAEGPATGKRFLVLTRISSIIPDDELVFWKQLTAKNKDVSLVVVSTSRSPRSLFAQKDGGAKVLSPETAMRETEMAMKAGAGVEGMGAGESEMGTMGAMGTMGAMGAAIMGSDSGGEAKAPGATKDPGEKAESPLAFLRGAPFMGAPFLGLSPPEAPAADYVLRDPRLDIVGVVPRTPLPSFNSPTRFGLRTGYLVRETRAKRYLVFEVTLLSCSAHWSLGGVMRLLLHHYKKLMVLNDILGVAGDEPETLVPWHINAVVKTVDYLVHVNVDQATTP
Length1684
PositionKinase
OrganismClavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Clavispora.
Aromaticity0.08
Grand average of hydropathy-0.449
Instability index48.88
Isoelectric point5.28
Molecular weight184857.68
Publications
PubMed=19465905

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25809
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.31|      26|      26|     672|     697|       1
---------------------------------------------------------------------------
  672-  697 (50.07/36.83)	RDERGEEREGE.RTEPAEMQRTDRGDT
  699-  721 (42.65/29.96)	RTERGE...AM.RTDRGEAMRTDRGDT
  749-  773 (30.58/18.79)	SDVDEEFSSGElRTSPLKLNTTS.GD.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.01|      27|      30|     414|     443|       2
---------------------------------------------------------------------------
  380-  402 (30.38/14.91)	....FSIPSALSTG...ASTGG.........EETKHETQ
  413-  442 (41.65/31.69)	QDDTFFDPSDPNVGlehKHNAT.........EQPKSEEE
  443-  478 (34.98/18.40)	DLEDLFGYSSDSDT...KKNTQdegsadgkeEDIKKEEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.30|      23|      25|     316|     340|       3
---------------------------------------------------------------------------
  316-  340 (32.85/26.99)	LLQFgSVeECVQTDP..DPSAKDPLSL
  344-  368 (40.45/23.11)	FIQF.SI.NCHNAEPalKPPVPEPIGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.40|      11|      17|    1359|    1371|       4
---------------------------------------------------------------------------
 1359- 1371 (17.98/18.48)	KRWICAawSDPLG
 1377- 1387 (24.42/14.99)	RSWFCP..RDGTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.45|      12|      17|    1298|    1313|       5
---------------------------------------------------------------------------
 1298- 1309 (21.90/21.73)	ARLSLALYDKCP
 1316- 1327 (22.55/ 8.79)	ARLHTHLVRAPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.01|      26|      26|     587|     612|       6
---------------------------------------------------------------------------
  587-  612 (48.07/29.33)	GRGLSGDGYV.FSPISFNP.KIRSSI.DT
  615-  640 (29.57/14.85)	GKG..GKFYV.AREASSGPeESRSRLrET
  817-  843 (38.37/21.73)	GTVLSDTQYLsFSPMPAAE.KASSHI.DT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.15|      34|      37|    1485|    1518|       7
---------------------------------------------------------------------------
 1485- 1518 (59.60/34.16)	KAGAGVEGMGAGESEMGTMGAMGTMGAMGAAIMG
 1524- 1557 (59.55/34.13)	EAKAPGATKDPGEKAESPLAFLRGAPFMGAPFLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.63|      11|      17|    1007|    1017|       8
---------------------------------------------------------------------------
 1007- 1017 (19.89/ 9.29)	PLSYQIALGEF
 1027- 1037 (20.74/ 9.97)	PADDQLFLGDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.34|      34|     430|     777|     811|       9
---------------------------------------------------------------------------
  777-  811 (56.82/32.82)	WPPASAV..DTQKQTQaSFALGSGLL....SPGQTRALGSK
 1208- 1247 (49.52/24.47)	WALAELVklDLINKTR.RFDFGRPLLvlfvSFDQSLAQASQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.21|      10|      31|     269|     278|      10
---------------------------------------------------------------------------
  269-  278 (19.24/13.27)	DLTKKKQILW
  301-  310 (19.98/14.06)	DVENKKYILW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     171.11|      54|     725|     136|     221|      11
---------------------------------------------------------------------------
  136-  195 (83.46/66.79)	AFASLSFLKAVKKCI.VYSLS....LSGQMQIFGnylVARAPGSSFQktvVQTDPILLANGDLIV
  861-  919 (87.65/45.71)	AGESTNCLPLILRSInVYSIPsrflLRKALQWGG...VALAPGFDMD...VDNDDDFDSPGALSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.22|      14|     390|    1042|    1055|      12
---------------------------------------------------------------------------
 1042- 1055 (28.94/18.35)	PGD..VFWHTLAPEQQ
 1429- 1444 (22.28/12.37)	PDDelVFWKQLTAKNK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.75|      11|      31|    1253|    1264|      13
---------------------------------------------------------------------------
 1253- 1264 (16.30/14.49)	RNLRsFLSDHRL
 1287- 1297 (19.45/11.50)	RRLR.YLSAGAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.00|      23|      26|     530|     552|      14
---------------------------------------------------------------------------
  530-  552 (43.72/22.98)	IPRDQMITAPFEPST..TTYDDPGA
  557-  581 (38.28/19.23)	MPTPILQSTPFHSSTanTAQAKPPA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25809 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APARMLEEAGAPQNSAPQNSAPQNSAHNKTGAGSDSVAL
2) GGKFYVAREASSGPEESRSRLRETSVYNATDLPFRREVNSSAPETEEAFSDGIERRDERGEEREGERTEPAEMQRTDRGDTMRTERGEAMRTDRGEAMRTDRGDTFDDTFHMGIEDVEDEDDEDEEEDDDEESDVDEEFSSGELRTSPLKLNTTSGDIFHWPPASAVDTQKQTQASFALGSGLL
3) KVLSPETAMRETEMAMKAGAGVEGMGAGESEMGTMG
4) LKPPVPEPIGLTDPGSVGNIPPFSIPSALSTGASTGGEETKHETQMLNQVPNIFSQDDTFFDPSDPNVGLEHKHNATEQPKSEEEDLEDLFGYSSDSDTKKNTQDEGSADGKEEDIKKEENDFKEDHEDFEQDNETENVQKSPASRDSNIQEESDVSFQVGNKQTGEESFINIPRDQMITAPFEPSTTTYDDPGAPLPIMPTPILQSTPFHSSTANTAQAKPPAEAKKGGRGLSGDGYVFS
952
617
1469
358
990
800
1504
598










Molecular Recognition Features






MoRF SequenceStartStop




1) GKFYVAREA
618
626