<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25806
Description |
Mediator of RNA polymerase II transcription subunit 5 |
Sequence | MDSEISLKKLIKVSIKKKSPPKVFLDLVKQWLEKGDRSDNEILESLIELHPSLISEQEQKSLQLHYAIQLACSSLDEHRRFMKLLPQSTLDSQRDYILYLRNNLKSLFSENMMREFINGTFVEYSKGICERMRSNLSATLKRLWTYILFLWGTIIDHYDSFITVPVFKDLGIHIVGTLKDLGDSNMLAYFSNKANSILNPSELHKDVHLPIATQKHKTEVPSIASMKRALALNGSSKKIQHYFKFKRFIWLNSRFRLWESNDVVEKYFSFFKISTQKIEDVIKEIFSAFFGGITTAIHSHEDAFVIFNWKTFIVSRLPQVLKESKVVHNQTIPENIEKMILSEMHQYNDEVITKMTVGGMKDKPFDLRKQFLKSCVYTRVISLDAMLKIFPEETENVSPALITHEREQLAHVESLSSDINSRLLDINTELTSLEESKLIETFQNIPSSNIIFSIMKQQQLCKSTHRAIDVLIREKSCEKLSRLILALANVLPVANYIFYNDEKGPWGILDKLISFLDGESFGVDADDSSFQDTYAHFGILLAGVILLTSNFGIDFDNVCIETSYTVTYINRIFFRSAGDMTDRFEGEDEQEKNIVQNYYNLMGAWLNALFDVNNEGLSDDLIKSVGVKQIYK |
Length | 632 |
Position | Tail |
Organism | Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Metschnikowiaceae> Clavispora.
|
Aromaticity | 0.10 |
Grand average of hydropathy | -0.181 |
Instability index | 49.97 |
Isoelectric point | 6.14 |
Molecular weight | 72867.92 |
Publications | PubMed=19465905
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364142
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP25806
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 96.69| 32| 110| 313| 346| 1
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313- 346 (52.44/38.21) IVSRLPQV......LKESKVVHN.QTIPENieKMILSEMHQ
419- 457 (44.25/26.19) INSRLLDInteltsLEESKLIETfQNIPSS..NIIFSIMKQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 98.64| 26| 113| 142| 168| 2
---------------------------------------------------------------------------
120- 139 (26.20/14.83) .....TFVEYSKG.ICERMRSNLSAT
140- 165 (48.27/30.25) LKRLWTYILFLWGTIIDHYDSFITVP
167- 184 (24.17/14.73) FKDLGIHIV...GTLKDLGDS.....
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 93.72| 27| 28| 499| 526| 4
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499- 526 (45.58/35.68) YNDEKGPWGILDKLISFLDGeSFGVDAD
530- 556 (48.14/32.79) FQDTYAHFGILLAGVILLTS.NFGIDFD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 46.32| 15| 16| 261| 275| 5
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261- 275 (27.88/17.30) NDVVEKYFS.FFK.IST
279- 295 (18.44/ 9.02) EDVIKEIFSaFFGgITT
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 39.63| 11| 353| 239| 255| 7
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226- 236 (18.17/16.38) MKRALALNGSS
245- 255 (21.46/ 6.57) FKRFIWLNSRF
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