<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25801

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNESVSSATTNGTSKGKGGTPPLPELPHITNNIISLSNVLRFHTQEAYKQLSRLIENLANTRTSESDVSRKRKFLELIISLRQDFIKIYTLVKWAQNSKDVSKLIDILNWLRTQEFYFDNLGYGLNELNNFSGAKLPNSDILTSLEVLVKGRPQLPSYNFIERPKISPERILEVLRDLNLTLVARMALIDDMSPRFQKNYVVRDGRVTITIPNEFEVSITVANDLIVENEEDYYKSPFFFIDFAFLFGINPESSLITHRDSNIITRLPKTSREKLEAVVNQVLLKQSLKGLYSLLHEYAVSFKLYLISKQLKDLSVNSKWRNNIQFKYNTSLIIINYWSNHYLSRNWKSFIEIGIDKQYNLNFRWFKNGKYNFNHDIQDISGADSDTGEPADLSVDFILNLVINKHSEMLISKIFKQLQEMTTDFVSYNNPYQLSIKLTPKRTTILAINPLTGFFYFMDPSLIESQCQNRINNQPSQVKNRSFISEQDMVVNVVSNLVQLRLDTFNRSLSTKLITTEWISNNIIKLNDYETAKLFNFILDEKTMTHNTISFYRCRTWPSSWFLINMISGLTSNTYWWVARLKSIKGEWKIQWVQMLKAREEQDFDYKFFTNLSKSCSNMIVDHMVTEELQKRSIQFVKVTNHSVLTRFNIPHTLRNTVSDHQTVIALHNTGNLLPVSVTSNTLFLVVQLVSENNSSKLNLTICGNFSSGSQADEETFAKLNVKINPDTQTFEFSNSMDLSSKSIENGESNTAHNLVNQLLSTVEKVNTLIQMLNQLKKTDIRVTNNSFSEITFDVDPLYKHFHLNLPANDLAALTLAPSEDEDQLVKLITKFLSQQMNESHTALVGTIEYLKQYVPIFKTIGVLKEILKDISKERLPNELRRLQLESKFSNLNCVQFLFYINSLGAPNSKKVHMDKIVFSLSFKRNKFDKAKRLLLKVSLKENLNSENLKYKKLFEDIFRAATELQQEKPKGTVFVKLNYDFLMDPDMLEPLMRKVTDCFLRFLKT
Length1006
PositionTail
OrganismClavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Clavispora.
Aromaticity0.10
Grand average of hydropathy-0.293
Instability index33.68
Isoelectric point9.01
Molecular weight116419.15
Publications
PubMed=19465905

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25801
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     450.79|     105|     105|     565|     669|       1
---------------------------------------------------------------------------
  389-  445 (53.28/26.46)	........................................EPADLSVDFILNL........ViNKHSEMLISK.IFKQ.LQEMTTDFVSYN....................NPYQLSIKLTPK..RTTI...........
  448-  547 (117.90/67.72)	..IN.PLTGFFYFMDPSLIESQCQNRInNQPSQVKNRsfiSEQDMVVNVVSNLvqlrldtfN.RS....LSTKLITTE.WISNNI..IKLN....................DYETAKLFNF.......ILDEKTM..THN
  565-  669 (179.52/107.07)	NMIS.GLTSNTYWWVARLKSIKGEWKI.QWVQMLKAR...EEQDFDYKFFTNL........S.KSCSNMIVDHMVTEE.LQKRSIQFVKVT....................NHSVLTRFNIPHTLRNTVSDHQTVIALHN
  672-  774 (100.09/56.35)	NLLPvSVTSNTLFLVVQLVSENNSSKL........................NL........T..ICGNFSSGSQADEEtFAKLN...VKINpdtqtfefsnsmdlssksieNGESNTAHNLVNQLLSTVEKVNTLIQMLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.34|      45|     651|     245|     293|       2
---------------------------------------------------------------------------
  245-  293 (61.60/61.15)	FLFGIN....PESSLItHRDsNIITRLPkTSREKLEAvVNQVLLKQSLK.GLYS
  897-  946 (69.73/48.29)	FLFYINslgaPNSKKV.HMD.KIVFSLS.FKRNKFDK.AKRLLLKVSLKeNLNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     300.01|     101|     768|       9|     121|       6
---------------------------------------------------------------------------
    9-  121 (153.21/119.71)	TTNGTSKGKGGTPPLPELPHI...TNNIISLSnvlrFHTQEAYKQLSRLIENLANTRTSESDVSrkrkFLELIISLRQdFIKIYTLVKWAQN.SKDVSK..LidiLNWL.RTQ.EFYFDNL
  784-  892 (146.80/88.28)	TNNSFSEITFDVDPLYKHFHLnlpANDLAALT....LAPSEDEDQLVKLITKFLSQQMNESHTA....LVGTIEYLKQ.YVPIFKTIGVLKEiLKDISKerL...PNELrRLQlESKFSNL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25801 with Med14 domain of Kingdom Fungi
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