Description | Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MADSDRVRLHLDKSLYGKNQDPFLQDEDSIPIAELLPQILRERQSFLNITEDSLQAEIEQKNKGIDTFEDNETQPVEETDEDTESAFQKFQKQKMELLGHINSAMNETSLSLDFVSLLMSGQKPNVSKATMSPYLTKHVPLGSLGSDRLSQNSEPEHNKGDGDAQKVASVGLGWKYQSLNHISELFKGAGSQLRSQVEVERHYWNSINTVLNHGEVLFSLRDPLTNSRAIGVKYGYGDSGSNYFDKGLAVLRKDDETGEITFSPITTGSHRLSHKATKFTRVKILSKIDNDFMLTGQSLFEKKCMEDKSEHKVINDIERARYFLFEEDLFYHLIREAKNLISYNVSIISNKIIIEIYDQIIEIESVIYDENNEEELSNTYQNINKESSKNNDKAQAILTFLKLMLCCYYNFNLELKQKIPTSFTKWKQNNTHPLMLRPLIGNIRHEHNVHSMKRIIHRICKSLDSSLFSHEVKEEKFLNLKADKITNPFKKAITKPISTFTLILQKLATKEHLNVEVEVTTSDIFVNLILILTVTKYKTNEDLQQNQDGSNVLQLKFSDFTEIEESMNWTILNFLQSQ |
Length | 578 |
Position | Head |
Organism | Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Clavispora. |
Aromaticity | 0.08 |
Grand average of hydropathy | -0.534 |
Instability index | 52.08 |
Isoelectric point | 5.71 |
Molecular weight | 66451.37 |
Publications | PubMed=19465905 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP25798 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 106.46| 27| 30| 159| 186| 1 --------------------------------------------------------------------------- 137- 162 (32.68/18.68) ..KHVPLGsLGSDRLS.....QNSEPEHNKGDG 164- 190 (47.74/32.56) AQKVASVG.LGWKYQS.....LNHISELFKGAG 191- 218 (26.04/10.22) SQLRSQVE.VERHYWNsintvLNHGEVLF.... --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 64.59| 21| 42| 11| 32| 4 --------------------------------------------------------------------------- 11- 32 (33.36/26.21) LDKSLYGKNQ..DPFlQDEDSIPI 54- 76 (31.23/19.31) LQAEIEQKNKgiDTF.EDNETQPV --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 87.98| 27| 65| 413| 439| 5 --------------------------------------------------------------------------- 413- 439 (50.63/34.75) LELK.QKIPTSFTK..WKQNNTHPLMLRPL 478- 507 (37.35/23.74) LNLKaDKITNPFKKaiTKPISTFTLILQKL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 60.33| 17| 29| 292| 308| 6 --------------------------------------------------------------------------- 292- 308 (30.49/23.77) FMLTGQSLFEKKCMEDK 322- 338 (29.84/23.09) YFLFEEDLFYHLIREAK --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DRVRLHLDKSLYGK 2) EIEESMNWTILNFL | 5 562 | 18 575 |
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