<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25798

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMADSDRVRLHLDKSLYGKNQDPFLQDEDSIPIAELLPQILRERQSFLNITEDSLQAEIEQKNKGIDTFEDNETQPVEETDEDTESAFQKFQKQKMELLGHINSAMNETSLSLDFVSLLMSGQKPNVSKATMSPYLTKHVPLGSLGSDRLSQNSEPEHNKGDGDAQKVASVGLGWKYQSLNHISELFKGAGSQLRSQVEVERHYWNSINTVLNHGEVLFSLRDPLTNSRAIGVKYGYGDSGSNYFDKGLAVLRKDDETGEITFSPITTGSHRLSHKATKFTRVKILSKIDNDFMLTGQSLFEKKCMEDKSEHKVINDIERARYFLFEEDLFYHLIREAKNLISYNVSIISNKIIIEIYDQIIEIESVIYDENNEEELSNTYQNINKESSKNNDKAQAILTFLKLMLCCYYNFNLELKQKIPTSFTKWKQNNTHPLMLRPLIGNIRHEHNVHSMKRIIHRICKSLDSSLFSHEVKEEKFLNLKADKITNPFKKAITKPISTFTLILQKLATKEHLNVEVEVTTSDIFVNLILILTVTKYKTNEDLQQNQDGSNVLQLKFSDFTEIEESMNWTILNFLQSQ
Length578
PositionHead
OrganismClavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Clavispora.
Aromaticity0.08
Grand average of hydropathy-0.534
Instability index52.08
Isoelectric point5.71
Molecular weight66451.37
Publications
PubMed=19465905

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25798
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.46|      27|      30|     159|     186|       1
---------------------------------------------------------------------------
  137-  162 (32.68/18.68)	..KHVPLGsLGSDRLS.....QNSEPEHNKGDG
  164-  190 (47.74/32.56)	AQKVASVG.LGWKYQS.....LNHISELFKGAG
  191-  218 (26.04/10.22)	SQLRSQVE.VERHYWNsintvLNHGEVLF....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.59|      21|      42|      11|      32|       4
---------------------------------------------------------------------------
   11-   32 (33.36/26.21)	LDKSLYGKNQ..DPFlQDEDSIPI
   54-   76 (31.23/19.31)	LQAEIEQKNKgiDTF.EDNETQPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.98|      27|      65|     413|     439|       5
---------------------------------------------------------------------------
  413-  439 (50.63/34.75)	LELK.QKIPTSFTK..WKQNNTHPLMLRPL
  478-  507 (37.35/23.74)	LNLKaDKITNPFKKaiTKPISTFTLILQKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.33|      17|      29|     292|     308|       6
---------------------------------------------------------------------------
  292-  308 (30.49/23.77)	FMLTGQSLFEKKCMEDK
  322-  338 (29.84/23.09)	YFLFEEDLFYHLIREAK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25798 with Med17 domain of Kingdom Fungi
Unable to open file!