<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25784

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSLLLFWFLEFRGYLGWLEMSQWHPYDSSPILDTINKLGALKDGLYNDDSLSVERSLKKSFHDTNSFRMARFDAVYYSAYRIDSELQDHKEAKNKSKGKCPLVHDLELLLSAKLSNKGIYSIAHLKDYWCFWIDTTGQNISVFEQDEFLSLIHSSTISVKRITLGMFTSNDLFQNPSSSKLINNIYINFLRALKKHLIKLFADNCPVKNSSSKVFPFSTHLLLQTDNFNYFNVLRLDLMINHKNEVLVSTTVAENPRFYNLASRENLETTVQKSSYAIYLCPSGIRCNFAVNGCLKDSITSDPPKDYERLLQLLKKYNNIFIDEKNTRWVKVVPNVNHLNNLSPHISSFLEDSHTGDGSTSLRFIAWPLSLCFVQYGVNIDGTIPPSSQYDPFKLLDQRISYIKEQQNHGVEEAIEELQDFCLPPEEDNIKGVKDSISPALEATCPSPIVEVDISDAYFDGVLDDVMNEEISLPKSEWNELFGEEAEENEIASPNGESFVMNSKEPVKLPTTTNPFYEDPGAPEPAPLPIISEISPCVHKATSVFSPLRFNPVIHDNIDIKYSTGGKFYVDRSESPSGPHKDSLTNAKLFLKAPTTGVGISGNSWTREEDSDLESDSDDDQDRLLKEEEEEEEEEYNNEKYQDRRDLIQKEGEKKENDKTKIQEDFYQVMKSSEGDEASPQADFDMIDGSDHNEGKKLEVERNTVAGNLRIHIRECNNSALTTIPIPSGGSNDTMDNLSQNWVPFIMRTVPLYSIPVCFLYKAPSLSKDRLNQELPILLKAILFDLPGSFSNKCRHDHQVQSKVDKLVRDVLPGIEKLSLLDFVGPGRISDGLFNIVNRENCPSTTSIEYDSRDSVSNEAFLGSPSLPTTQEGFIEKMLPNDTNLLIHTTPTMINVKRSDEDLSVGITSAKFWKSLGLQPLEGPNNFQAIAIVPDFGPQFLAQATDFIGNLQEEYKTNKLGEMSLIEIANDSVLRITPNEQEKSYWKNVHDTLQSHLNDICNRLKPEMPLLIIFINPFTSLVSVIETSQVLRELRDSISRLLNLNSSSESKRRKKKSTNGPNANYRKGSEIKNISISQKSIPLNDFFLIDGSYCVPSQKVLTRISLQLYCLVTSGHFTNNIALIAQEIPSAINFKLTKVPIARQLIIDDLYIHLAYDRATDKSWCAACWTDQYGGLREVKAWYSERRKFLNGGANLMKSFEEISNDIWSITMEYIKCHPGKSYLILTRLNNIIPDDELIQWKRLSLLNKSIYLVVLTIDLEPTLKLSGVSRESEGSGGVNNVMTTTMYPDSTAGIYPNTAESLGSRFDSPDISSNMFQTPSSPAFNTSGNFYSESDGTIVNISEELLGLVLSIPVPLSNQINRIPIRTGYLIQTANLTEGKSILEVNLLSCPAFIDPVDLMKKMLCQYRNLADLKNFWYASIVDETCNPFPWHILTVSKILKELVHVGVDE
Length1451
PositionKinase
OrganismKomagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Komagataella.
Aromaticity0.09
Grand average of hydropathy-0.358
Instability index49.41
Isoelectric point5.09
Molecular weight163898.49
Publications
PubMed=19465926

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25784
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     647.93|     256|     813|      81|     521|       1
---------------------------------------------------------------------------
  231-  319 (47.38/226.17)	..............................................................................................................................................................................................................................................FNVLRLDLMInHKN.EVLVSTtvaeNPRFYnlASRENLETTVQKSSYA...IYL.CPS...GIRCNFAVNgcLKDS.ITSDPPKDYERLLQ.....LLKKYNN
  320-  638 (370.21/312.53)	IFIDeKNTRWVKVVPNVNHLNNLSPHISSFLE.DSHTGDGSTSLRFIAWPlSLCFvQYGVNIDG.TIPPSS.QYDPFKLLDQriSYIKEQQNhgVEEAIeELQDFCLPPE...EDNIKGVKDSISPA.leATCPSPIV.EVDISDAYFDGVLDDVMNEeiSLPKSEWNELFGEEAEENEIASP.....NGESFVMNSKEPVklptttnpfyedpgapepaplpiiseispcvhkatsvFSPLRFNPVI.HDNiDIKYST....GGKFY..VDRSESPSGPHKDSLTnakLFLkAPTtgvGISGNSWTR..EEDSdLESDSDDDQDRLLKeeeeeEEEEYNN
 1013- 1203 (230.34/102.98)	IFIN.PFTSLVSVIETSQVLRELRDSISRLLNlNSSSESKRRKKKSTNGP.NANY.RKGSEIKNiSISQKSiPLNDFFLIDG..SYCVPSQK..VLTRI.SLQLYCLVTSghfTNNIALIAQEIPSAinfKLTKVPIArQLIIDDLYIHLAYDRATDK..SWCAACWTDQYGGLREVKAWYSErrkflNGGANLMKSFEEI............................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     236.41|      79|     812|      81|     163|       2
---------------------------------------------------------------------------
   81-  128 (63.44/50.08)	.......................................R..IDSELQDH..KEAK.NKSKGKCPLVHDLELLLSAKLSNKGIYSIAHLKDY
  133-  163 (28.40/11.83)	IDTTGQNISVFEQDEFLSLIHSSTISVKRIT.............................................................
  887-  947 (88.78/54.90)	IHTTPTMINVKRSDEDLSV...............................giTSAKfWKSLGLQPLEGPNNFQAIAIVPDFGPQFLAQATDF
  948- 1010 (55.80/32.76)	IGNLQEEYKTNKLGE.MSLIEIANDSVLRITpneqeksyWknVHDTLQSH.lNDIC.NRLKPEMPL..........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.88|      59|    1147|     169|     228|       5
---------------------------------------------------------------------------
  169-  228 (97.94/64.27)	SNDLFQNPSSSKL..INNIYI...NFLRALKKHLIKL.FADNCPVKNSSSKVfPFSTHLLLQTDNF
 1313- 1377 (87.94/52.74)	SSNMFQTPSSPAFntSGNFYSesdGTIVNISEELLGLvLSIPVPLSNQINRI.PIRTGYLIQTANL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.13|      11|      16|     656|     666|       6
---------------------------------------------------------------------------
  656-  666 (19.80/ 9.71)	ENDKTKIQEDF
  674-  684 (20.33/10.13)	EGDEASPQADF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25784 with Med13 domain of Kingdom Fungi
Unable to open file!