<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25782

Description Cyclin-like component of the RNA polymerase II holoenzyme
SequenceMSASYWSSSQRLHWQFTRNELNEHREQIQALEKNLNVPGSDLSRINIKYDTNMRIYLHNLMHKLGRKLVLRQVILSTAEVFMTRFLLKVSIKEVNIYLLVATCIYVACKMEECPQHIRNLVSEARNCWPEFIPNDLTKLAEFEFYLIEELDCFLLVHHPYNSLISIVKDVLKDPRYNIAITTDELQTCWSIINDSYITDMHLLFPPHIVAITSLYMTLVTFSKDSKKLQTFVKFLAHCKVDLDEIIESTQELLTLYEYWNSYDELSLRKAVHRLLLTLNNSNQ
Length283
PositionKinase
OrganismKomagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Komagataella.
Aromaticity0.10
Grand average of hydropathy-0.091
Instability index50.13
Isoelectric point6.26
Molecular weight33367.29
Publications
PubMed=19465926

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
cyclin-dependent protein serine/threonine kinase regulator activity	GO:0016538	IEA:EnsemblFungi
RNA polymerase II core promoter sequence-specific DNA binding	GO:0000979	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by galactose	GO:0000411	IEA:EnsemblFungi
positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle	GO:0010673	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25782
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.55|      43|      58|      91|     135|       1
---------------------------------------------------------------------------
   91-  135 (75.85/63.58)	IKEVNIYLLV....ATCIYVACKMEECPQH.IRNLVSEARNCWPefIPND
  147-  194 (64.70/46.94)	IEELDCFLLVhhpyNSLISIVKDVLKDPRYnIAITTDELQTCWS..IIND
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25782 with CycC domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA