<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25781

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMISEVTDNIIPLKQILSTYCLHVYKELGESIKILQSNQDDHSKKKRFLEVLVTIRENFVRLFVLSKWAKSADDIYKLIKLFAHLRRLILEIGNVAHGMKFMGLSLIDAKLPNPDLRTAIEVVLKGRPQLKTYGFLQSKKLSSVLILRTIKEVNVILASRISMAKELPFLLRNYKVANGRITFHVSNFFETSLSIGDENENQLYMVYFHFNFGSLDNKLMTMTTHLDEGTQNLLFKKANRALRVDFVPVEQTNEDDSETKLPRHKSLTESLQRLCRLLCKFSVGYKLYLLYRQLVTLKVNIWKSDLSPVYYPDKNKIILTYWNQRNLRKPTIEISVSDNDTLSFEWFKGGILQKADGIKLADKAGTISMESLLMQITYKHVKQIIDHIVLQFDELLLDRSKVITYYTNDSIVFSLTPTKSTIYSIDPLSGLGYFTNPSSNKMVEIEDLINIDPQSTTRNLLRIKLETQLYELSYTMNSTGWISNDIVTLSTAEMKRLSINTKLFNLMNSSFNDSSLLLYKLKFYRRKQWPGGWFLIVGVNGFSSKIQWWLSYIKSVMGQWSIQWFEEIHVSVADYDYSMLLDLSNMTTEKLVSNLLMEELRNNYNTKVFVVDNKDHDRVLLSLSSEIKKHLPAKGPLLVLDNHSLTAIPSCESTILISLDVSTLDVLKLFVLGKLTDLPSHRMFDSLTENYRTANFATFSSKENCLFFRTYQEISFPVHSSLISTNLLGDSLHLIHQFTEMINLLSLTDQQAAIKALDVTLSKVKFEVGNEIYGKEHVSFLREGDSVSLVLSKTSPHRFCLPQMESMIQNRTKTMPLSTKINHLINYMQVTFSLVNFVNHLEKDLSSEVESHLQWTRFMYDINWFSLIYWSNAFQKPGKNQNLKLKRKVTLNIQIKNWTAVPTLVKTFINVNKEDLDSGGLESLEKIFKGENDKFNSKVKNCELRFLNVGIACSINFAHHILQELHHHIISELSPSSIR
Length978
PositionTail
OrganismKomagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Komagataella.
Aromaticity0.10
Grand average of hydropathy-0.137
Instability index35.20
Isoelectric point9.00
Molecular weight112810.29
Publications
PubMed=19465926

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25781
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.37|      22|      22|     321|     342|       1
---------------------------------------------------------------------------
  321-  342 (37.61/27.00)	WNQRNLRKPTIEISVSDN.DTLS
  345-  367 (32.76/22.55)	WFKGGILQKADGIKLADKaGTIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     361.96|     140|     330|     369|     541|       3
---------------------------------------------------------------------------
  369-  533 (188.72/192.15)	........ESLLMQITYKHVKQIIdHIVLQFDELLLDRSKVITYYTNDSIVFSLTPTKSTIYSID.PLSGLGYftnpssnkmveieDLINIDPQSTTRNLLRIKLETQLYELSYTMNSTgwiSNDIVTLS.TAEMKR.LSINTKLFNLMNSSFndsslllyklkfyrrkQWPGGWF
  534-  564 (20.99/ 6.29)	LIVGVNGF.................................................................................................................................................sskiqwwlsyiksvmgQWSIQWF
  567-  644 (89.55/51.02)	IHVSVADY........................................................................dysmllDLSNMTTEKLVSNLLMEELRNNYNTKVFVVDNK...DHDRVLLSlSSEIKKhLPAKGPLLVLDNHSL.......................
  702-  765 (62.69/27.08)	........ENCLFFRTYQEISFPV.HSSLISTNLLGDSLHLIHQFTEMINLLSLTDQQAAIKALDvTLSKVKF.......................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.49|      23|     415|     258|     281|       5
---------------------------------------------------------------------------
  258-  281 (37.59/27.59)	TKLPRHKsLTESLQRLCRL..LCKFS
  675-  699 (37.89/23.03)	TDLPSHR.MFDSLTENYRTanFATFS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25781 with Med14 domain of Kingdom Fungi
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