<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25780
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MPPVDPELALSLDEVSQILLKRPGAVGIKGIKRLSNLYGFETFTDIIDPVNKASAIQSPGPLGMNEKELSTIERLTIAGKIILIDIDFQEQKVSDVSLSLAIVTKLISGKDKGKLNFIDKACEPNIEKLLLQNLNESTLDDFNRNLRLLSLLDKLSNSVSLNDQLNRETGSGNDELSHERKYDLFNYMHILSFNLHRVYEYQVSHLDELDYKSPFLSDRNDISCFVREGLGGIGKVELNVGGRCGVFLKFWEDHRFVTQQLKQRVPNDEIHNDNFLLHFKIKEVDNEYCIKNIDTRIVYKEKWFEEGRWLVDSGKNDNDIVKFSVTLVAELLPTVWVPYDLLYKWNIDDIDEAEPDVKNNRLDALFDHFNKFHHKRKYRLNEKGDQKLEISMMSPCRFVKLHKLSHRVEQIQSIVDDLRTWCVISSFIRNVLSSCESEEETRTNVKSELNVDDVKLVEFVSEKPIIVNNRRDDEFRLSFSPSMDDLDHMLTTVEFKENNVYKKLQFSIIRGILDDVKPLTDNIDESTVKIKAWKVFRTEQILRSFQVIKNS |
Length | 551 |
Position | Middle |
Organism | Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Phaffomycetaceae> Komagataella.
|
Aromaticity | 0.09 |
Grand average of hydropathy | -0.412 |
Instability index | 37.61 |
Isoelectric point | 5.49 |
Molecular weight | 63893.09 |
Publications | PubMed=19465926
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP25780
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 61.30| 21| 33| 12| 35| 1
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12- 35 (27.64/24.82) LDEV...SQIllKRPGAVGIKGiKRLS
47- 70 (33.66/18.97) IDPVnkaSAI..QSPGPLGMNE.KELS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 46.21| 14| 30| 368| 382| 2
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368- 382 (21.95/23.47) HFNKFhHKRKYRLNE
397- 410 (24.26/18.45) RFVKL.HKLSHRVEQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 52.58| 15| 30| 215| 230| 3
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215- 230 (23.36/20.38) FLSDRNDiSCFVREGL
247- 261 (29.22/20.21) FLKFWED.HRFVTQQL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 47.78| 14| 32| 492| 505| 4
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492- 505 (23.48/15.40) TVEFKENNVYKKLQ
527- 540 (24.31/16.18) TVKIKAWKVFRTEQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 105.30| 31| 41| 136| 166| 5
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115- 142 (22.96/10.51) ......LNFIDKAcePNIEKLL.LQ.N.lnE...STLDDF
143- 176 (44.68/27.41) NRNLRLLSLLDKL..SNSVSLN.DQLNretG...SGNDEL
179- 209 (37.67/21.95) ERKYDLFNYMHIL......SFNlHRVY...EyqvSHLDEL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 82.34| 26| 33| 415| 442| 6
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415- 442 (40.09/28.04) VDDLRTWCVISSfiRNVLSSCESEEETR
451- 476 (42.25/23.41) VDDVKLVEFVSE..KPIIVNNRRDDEFR
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