Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MTDYSKVPINSLESLRLRLTQAMHSLNKLNDSIHQSQTLPQWSSIQNQLTVILSQLTSLSTTLETQREILQYINVYPLPEFPSTTHEGLLTTLLRKKNIPEVSEWITQSLEESKDKNPSASDQFATWCAETSAQESENWIFTGFRTKYEIDNDIPQAPEYSLRESTSTNVSQDEVSTDDLNKLIYMGIDPRKQ |
Length | 193 |
Position | Head |
Organism | Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Komagataella. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.635 |
Instability index | 53.37 |
Isoelectric point | 4.74 |
Molecular weight | 22115.36 |
Publications | PubMed=19465926 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP25778 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 35.46| 11| 28| 59| 69| 2 --------------------------------------------------------------------------- 59- 69 (17.96/ 9.78) LSTTLETQREI 89- 99 (17.50/ 9.39) LLTTLLRKKNI --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DEVSTDDLNKLIYMGIDPRKQ 2) NWIFTGFRTKYEIDNDIPQAPEYSLREST | 173 138 | 193 166 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab