<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25777

Description Subunit of the RNA polymerase II mediator complex
SequenceMNNTPLDELQWKSPEWIQTFGLRTDNVLEYFSQSPFFDRSSNNQVLKMQSQFNEQFQIQLQQNPHFLQQELKKMKGVEFIVAYTQEPNFWVIRKQFRKSPNEADALNDYYIIGANVYMAPVLNDVISSRLLSTTLALRKAMNTLHQMPKFSPTEGHYYHQDTDPYLGDKSRPGTIINTPNIGTTVSNTNLNTPSDKEAADRNTNSSTLISLLNML
Length215
PositionHead
OrganismKomagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Komagataella.
Aromaticity0.10
Grand average of hydropathy-0.619
Instability index50.53
Isoelectric point6.08
Molecular weight24772.57
Publications
PubMed=19465926

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi
RNA polymerase II preinitiation complex assembly	GO:0051123	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25777
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.39|      25|      49|      12|      37|       2
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   12-   37 (41.57/27.12)	KSPEWIQTfGLRTDNVLEY...FSQSPFF
   62-   89 (40.82/22.06)	QNPHFLQQ.ELKKMKGVEFivaYTQEPNF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25777 with Med6 domain of Kingdom Fungi
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