<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25776

Description "Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme"
SequenceMNRLYNQTQQPMRMASNDFFSIGPYRKRKDQSRESVLDKYTILGYIASGTYGKVFKASGKSKDNQKQFYAIKKFKIDSKDSEITHYTGISQSAIREISLCKELKNENVINLTEIVLENKCIYMISEFAEYDLLQIIHHHSHPDLKPINEQMLKSILFQILQGLNYLHENWIIHRDLKPANIMVTSEGIVKIGDLGLARKFNNLLQTLYTGDKVVVTIWYRSPELLLGARHYTPAIDLWAVGCILAELLSLRPIFKGEEAKIDKKQLPFQENQLLKIIEILGTPTVHSWKSLKDYPEYHQLSKFNIFPPNLSAWFHSMGGQNKNCLGLLSNLLQYDPADRLSAHSALSHDWFSESPAITKNVFKNTKVKYPIRKIQKDDVNLLNQSQQYSNIGQKRAIQDDGSRKRRA
Length407
PositionKinase
OrganismKomagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Komagataella.
Aromaticity0.10
Grand average of hydropathy-0.448
Instability index44.24
Isoelectric point9.35
Molecular weight46932.46
Publications
PubMed=19465926

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25776
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.36|      21|      29|     133|     154|       1
---------------------------------------------------------------------------
  133-  154 (36.25/33.72)	LQIIHHH..SHPDLKPINeQMLKS
  163-  185 (34.11/25.72)	LNYLHENwiIHRDLKPAN.IMVTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.92|      20|      28|      23|      42|       2
---------------------------------------------------------------------------
   23-   42 (34.60/22.66)	GPYR...KRKDQSRESVLDKYTI
   49-   71 (28.78/17.68)	GTYGkvfKASGKSKDNQKQFYAI
   73-   87 (15.54/ 6.35)	.......KFKIDSKDSEITHYT.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.04|      20|      23|     268|     288|       4
---------------------------------------------------------------------------
  268-  288 (30.45/22.06)	FQENQLLKIIEILgTPTVHSW
  294-  313 (38.60/23.23)	YPEYHQLSKFNIF.PPNLSAW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25776 with CDK8 domain of Kingdom Fungi
Unable to open file!