<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25773

Description Uncharacterized protein
SequenceMETNRASEHSIQVPPGVYPLNGHDSVNEGPKTELIYPDFKIWQHSPQDDIIMTRYLQKGFFEAPVVQNESLSARSLMAVSLHENSNEPNASEEQTAKAPNPKIKLLSDYIIQAIFQRRQLSKIHTKVIVRPPPRVTLTEHKREKWMENLANTRIPLSQLARAIPHGIKNRILLEQCCLYNVPVARAVWLVKCVAGNEVRVLRRKVQQSSTNALSTNAIFNTWLSDWTDQVTNFLERFMISIFTPNQKDWRERSNYNLTLVGNLFMEDLLRQDKFLGWIVSFLRQCLVKLSSGSKEEPDHVSQGLNLLTIHLVILRLFWFKILKSDHISKEASVVLLQLHAKLVDKSTLQSGNSPSTFIIELKENINFLIKYLFYYSPDAFIIPNYWHDLKHTLKKILDTSNNLVRTQFKLVTYRNESLIVNLPQSLNKPLNLNQDEPLQSNRDDLLKSLDTFFSSSDSIGTLTSLVFEKIDEDEETEIKTFAPDIEPNEPEASETIEIDSPIKNSPIPNNKEVSPPITTKKGNKKDTRKLWSYNFRLLLNWSISNYRNQSSSVVQVNLVVSILEQRLREIYSNTTNLRAKKLKLEIELELLDWIFQINDSYNVLKQNNETEIVYKLETLEYLCARCYQSGLLTVSSYIRKLIASGVIYLPDCFKNSTIHSLVLKSLPVLKNNNLDNILRKLSNKEEPYDSAKDILFFEEAKSSLLPFIEWIVSDFEINLDPVWNCLKSLDTKTAILVSEWFMSETFRLLFERTANKNQVKVTEKKLSLITYALVEKLNCLPQFYVKLLQAFALELKSFSIDKMTMIFISEIIQFHEQQAAVFSAKEETNAYTNMIKSLFQVVDEGKYLINWTVFKPTLVNDKNVISELSKRIELSKKSYIKDLSNLYQLNLRSSSFLLHNMNSKVENLLNFNGLVHNTHTLAGRLWDMVRKKSFTNTDIPPDQYERDLFQSLKLMKLERPNDLVKAVLAYTKKNVLATLSLEYTSITTYILKLFLNEVLDLEQLWDLFSTVNDTFTDVSCQKFLKGLMFDKYFSDIECIQLLSDFELLKLKMVRSKVKQTDFKSWCSRMRQCLLEIDSPETNNGRTNSTPVSTELDQLPTSTTNNLPTPMQLMSTPTTVSNFDSMLSTTPFNSFLSRFKDEVMETCKEMINVHTELSIKFFNGLTSSLQGEGMSIRILNQLLLQNDQVIVSCNDMSKVLQLLDPLNLGVCQLLTKTLHEKAFQYKRKKNSMNHEEKSSLMADLTLCFLKDLMKMPKYQHSDHKSLELVGELFRFLEPDLKLLLLHSCELFFLTSEMFPLVNSREDNPGDNTLDILYLIINSCTRYEDLFSLSSKYQNGIPIPDNLVFSLTVSLEKMIGKCARPKRKLDKHAEQKAIESSILLVCRIILIHKGYLVGLILKRSTGNINKDSFLQNLVKLFNSKFIKSSSKLENLLYDIIVSIKILIGEHIGSTNHEILNVSPPDYSNKLNYLLENVSFQDGLRMSNDSQELFVQNTKTKTLSKFYIRPYELLPETTTKMEESCINLHLFNASTELKNPK
Length1538
PositionKinase
OrganismKomagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Komagataella.
Aromaticity0.09
Grand average of hydropathy-0.250
Instability index40.48
Isoelectric point8.08
Molecular weight177417.65
Publications
PubMed=19465926

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25773
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1403.03|     412|     430|     382|     811|       1
---------------------------------------------------------------------------
  157-  556 (409.21/255.63)	...............................................................................SQLARAIPHGIknrILLEQcCLY.....................................NVPVARAVW.LVKCVAGNEVRVLRRKVQQSS..TNALSTNAIFntWLSDWTDQVTNFLErFMISIFT..PNQKD.W...RERSNYNLTLVGNLFMEDLLRqdkflgwiVSFLRqclvklsSGSKEEPDHVSQGLNLLTIHLV.......ILRLFWFKIL..KSdhiskeasvvllqlhaklvdkstlqsgnspstFIIELK........................eninflikylfyyspdafiIpnyWHDLKHTL...KKILDTSNNLVRTQF.KLV...TYR.NESLIVNLPQSLNKPLNLNQDEPLQ..SNRDDLLKSLDTFFSSSDsigtLTSLVFEKIDEDEETEIKTFAPDIEPNEPEASETI.EIDSPIKNS.PIPNNKEVSPPITTKK..GN.KKDTRKLWSY.NFRLLLNWSI..SNY.RN..QSSSVVQV
  557-  957 (529.70/345.25)	NLVVSILEQRLREIYSnTTNLRAKKLKLEIELELLDWIFQINDSYNVLKQNNETeivykleTLEYLCARcYQSGLLtVSSYIRKLIASGV...IYLPD.CFK.....................................NSTIHSLVLKSLPVLKNNNLDNILRKLSNKE..EPYDSAKDIL..FFEEAKSSLLPFIE.WIVSDFE..INLDPVWNcLKSLDTKTAILVSEWFMSETFR........LLFER.......TANKNQVKVTEKKLSLITYALVEKLN...CLPQFYVKLL..QA................................FALELKSFSIDK.........MTMIFISEI..................iQ...FHEQQAAVfsaKEETNAYTNMIKSLF.QVVdegKY......LIN..WTVFKPTLVNDKNVISelSKRIELSK...........................KSYIKDLSNLYQLNLRSSSFLLhNMNSKVEN...LLNFNGLVHNTHTLA..G.......RLWDMvRKKSFTNTDIppDQYeRDlfQSLKLMKL
  962- 1367 (464.11/276.38)	DLVKAVLAYTKKNVLA.TLSLEYTSITTYILKLFLNEVLDLEQLWDLFSTVNDT.......FTDVSCQK.FLKGLM.FDKYFSDIECIQL...LSDFE.LLKlkmvrskvkqtdfkswcsrmrqclleidspetnngrtNSTPVSTELDQLPTSTTNNLPTPMQLMSTPTtvSNFDS...ML..STTPFNSFLSRFKD.EVMETCKemINVHTELS.IKFFNGLTSSLQGEG.MS..IR........ILNQL.......LLQNDQVIVSCNDMSKV.LQLLDPLNlgvC..QLLTKTLheKA................................FQYKRKKNSMNHeeksslmadLTLCFLKDL.................................................mKMP...KYQhSDHKSLELVGELFRFL..EPDLKLL.......LLHSCELFFLTSE....MFPLVNSREDNPGDNTLDILYLIIN.SCTRYEDLF.SLSSKYQNGiPIPDNLVFSLTVSLEKmiGKcARPKRKL................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.38|      14|     785|     271|     289|       2
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  271-  289 (21.31/11.39)	QDKFLGWIvsflrQCLVKL
 1059- 1076 (23.07/12.97)	QTDFKSWC.srmrQCLLEI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25773 with Med12 domain of Kingdom Fungi
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