<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25770

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMWDPLIPLYTDVLQKLGYVGVPEVLKLLLSYSTIYDESHPISKAGSDGRAVKRKRTISTLMTDNKIIQNAMAAITMGRGPKATRGAIDTFNAVADWISALLAWSPSGEGPDSEHFGGILGHKDAACIFGSLGLLLVALAATEKGVNALSSLSKNDRKRLGQALSSYTTVCAGYSIPLKSRLDSIQKDFNLYSGDENKGLEDSMMGDVNVAVLQFESNVVDSPAISSRAGLYIYINALLVGRPLVDDNMLLNYLNNRYGGHHMVMVEELITATFDVLSNGMYRNESSKTMFLFRAFLVNKLPPFLTYMSASSMASIPMELCITRSLSRVDPNTFPSFSETFSMQGNSVLSDVRQEFLFSCALHKLIPESSIERLLGENPMQTLPVGGQFTKDKLIMQMNNNFERAEQLLNGIESMDGNAGAIVDAITELMHNLCSRKETMTLKNICNSLSRRPQALDIMLLFKSPASILQPLCSLLDAWKWDEEQGENQLVYDEFGSILLIVIAFKYKYDLTPLDLGIDSPDSFVLRLLETGAASQRLDDLTEKQKQNLGAWIAALFVAEGISDESMSSCSPQEFYLLVATLFSQSLLACEAGKIEFETLKGGFEYHIWESETDLTTSLKILHGLVRPASISGEAQEIHRTVLCITSRTLESTLKDIRTRYPSRTDIKPILDVLEPYQSFRRTGATNNTELDTWRANPAGGGLVTSIRNTFSSLVLWSTDPEISMTPPSYTHRQLLAGVGHVGSEKVLQGLIDELKLQTETGSGDLAFDIAATLICAPIAESFSVDQALYRQAGDAKYSIPRCRFLTLRDALSLQRDSLSKLIETDPHRAELVVRLQRRLETLCSIPQMPPGEVDVDNIIENIHLGVGGASEPQQQSQQLQTVADQSNQGAVTTIGDTPGNLEAMLDAAASAAVADSNGGAGAASGLLGNGVGGAGVEVGTGMDDVFNMMDMDNPEFIDLDMEGMF
Length965
PositionTail
OrganismUncinocarpus reesii (strain UAMH 1704)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenaceae> Uncinocarpus.
Aromaticity0.07
Grand average of hydropathy-0.068
Instability index42.59
Isoelectric point4.82
Molecular weight105355.80
Publications
PubMed=19717792

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25770
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.73|      17|      20|     880|     899|       1
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  880-  899 (24.12/21.97)	QTVADQSNQGAVTtigDTPG
  902-  918 (26.61/15.10)	EAMLDAAASAAVA...DSNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     522.07|     184|     207|     351|     557|       2
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  351-  474 (139.13/136.51)	........................................................................................................................VRQEFL.FSCALHK...LIPESSIERLL....GENPMQT.LPVGGQFTKDKL..IMQMNNNFERAEQLLNGI...ESMDGNAgaivDAITELMhnLC..SRKETMTLKNICnslSRRPQALDImllfKSPASILQPLCSL
  475-  679 (263.14/231.06)	LDAWKWDEEQGE.NQLVYDEFGSILLiviafkykYDLTPlDLGIdSPDSFVLRLLETG...AASQR.....LDDL...TEKQKQNLGAWIAALFV......................aegISDESM.SSCSPQEfylLVATLFSQSLLaceaGKIEFET.LK.GG.F..EYH..IWESETDLTTSLKILHGLvrpASISGEA....QEIHRTV..LCitSRTLESTLKDIR...TRYPSRTDI....KPILDVLEPYQSF
  690-  848 (119.80/83.25)	LDTWRANPAGGGlVTSIRNTFSSLVL........WSTDP.EISM.TPPSYTHRQLLAGvghVGSEKvlqglIDELklqTETGSGDLAFDIAATLIcapiaesfsvdqalyrqagdakysiPRCRFLtLRDAL.S...L.QRDSLSKLI....ETDPHRAeLVVRLQRRLETLcsIPQM..................................................................................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25770 with Med5 domain of Kingdom Fungi
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