<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25766

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGLAMDGSGAVLPGTGVADAHCGPSRISCQPNGRVSLNGDGDPSISFMEQFPRLSDGHQASLDDLPPELAHITLGFFPFARLISRVVQQSWNDLNELVNDIGSSPPSQVDVVARLGSANPLSGKYRGEQHTENALNKIRLLEFAHTKRVEFIKLLVLSQWSRQANEVSRLIDIQAFIRMRYSLYGMVLHRIGNMKQDLVGAQLANPDLGTALHILSNEGNETIPAFGFLSPKPLGPRRMLNVLRRINKLISMRLTTCDNIPSAFKNHSIQDGRVTLIVPGEFEIDLSVAFETNSAQFFFVDMRFLFFPSSCPNGELQRILDQKVNAALMNFGLIGCFNLMHNLTLTHKITILFKQAADLTRTFWADHLRVELLHRTLIIQYWTKKPGKSWIEIGIRSGTKRPTEGAGTDTSFLHLRWVRDNEEVDATEIDFNLTQLSAESILFSVVSLHITHILRITFERLHQKALYSLGALYLGMGASSMEPGDCHLEVQFTQTRRMNMVVEPVSGDITLRIGPSPITRYDPEIIFDKNPVENVVERISRLRCAVALEEVESHAKAVGWISLNLRHISPDNLQRVFPSIALRRLYNTPFSSFANALSGMIVVRSNLEFLSEFTTIRFFPSTKGLVLQPYLRVPNIYIHLSTTFPTEKHKRSFLDERLRISYRGIDQQSGHAMTVVHGRFTTTVDDFGALFARPNKGFSFQTNGSGFTMVFSTPIGLPIITRLLDRLHQIDNMVFAVELLKSKGFKIFLLSPLRISFAYPSRKEFRGSIRYSYEEKSSQTRSESCVIPVSDPSSITHPRIDIGFNHQNPHRRIRESLSEILTFHRDGLKLVLELLNATLPLLCALEQICGDAYSRNARWFETQFTARSAKMYQIRYPFIRHRFNLSASQRKSHVVWVLQNSTRGSDRSNHPSLELRLRNEIYSVQGDGWRGINHGGIASSTSVDRLVFGLHNLVTSYIAQMTPRNPNDRLTESIPNVSHGLEGHSLKTENQSGQDDRFSLASKPAINGANGSPDTNVQSAQQERTTDVDVISID
Length1035
PositionTail
OrganismUncinocarpus reesii (strain UAMH 1704)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenaceae> Uncinocarpus.
Aromaticity0.08
Grand average of hydropathy-0.209
Instability index42.97
Isoelectric point9.08
Molecular weight116452.60
Publications
PubMed=19717792

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25766
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     263.00|      85|     104|     251|     354|       1
---------------------------------------------------------------------------
  210-  249 (22.70/18.22)	..............................................................GTALHILS.NEGNETIPAFGFlspkpLGPRRMLNVLRRINK.....
  262-  354 (139.23/86.62)	PSAF.KNH.SIQDGRVTLIV......PGEFEIDLSVAFETN.SAQFFFVDMRFLffpsscpnGELQRILD.QKVNAALMNFGL.....IGCFNLMHNLTLTHKITILF
  361-  444 (101.06/48.45)	TRTFwADHlRVELLHRTLIIqywtkkPGKSWIEIGIRSGTKrPTEGAGTDTSFL.........HLRWVRDnEEVDATEIDF...............NLTQLSAESILF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.31|      61|     476|      92|     186|       2
---------------------------------------------------------------------------
   92-  166 (85.97/123.20)	WNDLNelVNDIgsSP.......PSQvdVVARLGS......ANPLSGKY..RGEQHTENALNKIRLleFAHTKRvefiklLVLSQWSRQAN
  561-  636 (93.34/53.62)	WISLN..LRHI..SPdnlqrvfPSI..ALRRLYNtpfssfANALSGMIvvRSNLEFLSEFTTIRF..FPSTKG......LVLQPYLRVPN
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.14|      37|     104|     787|     830|       4
---------------------------------------------------------------------------
  787-  830 (57.13/46.11)	VIPVSDPSSITHPRidigFNHQNPHRRIReslSEILTFHRDGLK
  895-  931 (67.01/37.37)	VVWVLQNSTRGSDR....SNHPSLELRLR...NEIYSVQGDGWR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.80|      21|     109|     760|     783|       5
---------------------------------------------------------------------------
  760-  783 (32.84/34.07)	YPSRKEFrgsIRYSYEEKSSQTRS
  873-  893 (38.97/29.38)	YQIRYPF...IRHRFNLSASQRKS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25766 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RNPNDRLTESIPNVSHGLEGHSLKTENQSGQDDRFSLASKPAINGANGSPDTNVQSAQQERTTDVDVISI
965
1034










Molecular Recognition Features






MoRF SequenceStartStop




NANANA