<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25756
Description |
Mediator of RNA polymerase II transcription subunit 7 |
Sequence | MEEGGRQKGITAAFPPPPPFWRHFTPENLQKLEKAKREAGPQTQSHRWTPQALQALELPPELRYLVPPEFPKEGSYSLFGESQSLSGSLPSLEEQGLEQLFPSSLTDEAAGPSPDHAYYLLKISKSLLLNFLELVGVLSISPEHYEPKVDHIRSLFINAHHLLNVYRPHQSRESLITMMEEQLEKAKEEIQEMDQMKACVERYLKELETEGRTISYQGELEGTAEKLAAAAETKTAEPHLDGAQEMWDLLDQIENS |
Length | 256 |
Position | Middle |
Organism | Uncinocarpus reesii (strain UAMH 1704) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Onygenales> Onygenaceae> Uncinocarpus.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.623 |
Instability index | 59.18 |
Isoelectric point | 4.92 |
Molecular weight | 28988.31 |
Publications | PubMed=19717792
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery.
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364060
ECO:0000256 ARBA:ARBA00003669
|
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi
|
Interaction
Repeat regions
Repeats |
>MDP25756
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 62.38| 21| 25| 107| 130| 1
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108- 130 (33.09/25.98) EAAG...PSPDHayYLLKIS..KSLLLN
133- 158 (29.28/12.09) ELVGvlsISPEH..YEPKVDhiRSLFIN
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 79.24| 16| 21| 18| 33| 2
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18- 33 (33.43/19.85) PPFWRH.FTPENLQKLE
41- 57 (25.21/13.26) PQTQSHrWTPQALQALE
59- 72 (20.59/ 9.56) PPELRY.LVPPEFPK..
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 61.18| 19| 19| 207| 225| 4
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207- 225 (30.92/19.29) LETEGRTISYQGELEGTAE
227- 245 (30.26/18.73) LAAAAETKTAEPHLDGAQE
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