<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25755

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDGVSQHEDIWLAPTGSVCRYIGPDPMKSSSSQWDLSLRDYGNLDFSAGTSPLYPKEWKVAVYRHLQGFGLCLDEPGIEIWIEVEAHRPLEPQWAGSGAENQSSVAYKRFLWPARLCFRRSAQRPLAHVRGAELVDPTTLDPLKFAEKWFKEMDSGESPQVLMTALETQEPEDLQPRLAVVPEKINSPETFASLAHKITFNERSASAVYPTPPGGVTGAGFTPVPSVDKLPAFSAVGLNNLVQDKPGPVSAGLSQTGYRATPTSLPAVDATAPALEIGSGMYDTTVDDNPFDEMDDNLEAKEVTEADFNFFDEPDFTNFPGEGMEMSLQNTNDLFEDPPEALQAETLQPVDNAVGLPPLSAEEQEGGYNTESGEQSLVSPPAKVIIQENLGELNDGSSYEPVIPHRPLSPMNIRDILSTSCLSSLSPNPSSPSGRTTKGKSRTGYEPILFRENLNFSDGKYRLDGKFWFLPEVKSPKPSDRAAMNLSDIPTVGIPQWPNKEQRHLSWESTAGNRSEGDVQSSSISSNQSCDDDSEPGNISPDRCDTGLRLFLGTKDNSQLFKDKDFTPSPMELSTVNTEISNMGMDVTVSAFLRTLLFASTDWSLDGYFTLAAAYYPVLPQKGDLVQVAQLVVDQFTQSSLNHNRYECSRIKNDYQNILLFCSTEKDDWHGKFSSFDLKRYTSIDDENSMQGLRKDFRYATVGSLSKLDSPHIRIHRGKYDLEVLAPAVFFWESFGLEPTQGQKDIVAFCIHPESAVESADAFLDRFGLLYSSANFGQHSRPRGSKGLISWGLDPIGGREYPAVMRDVIASLPPGGETIVIYIVNPFPYEAAIVDICTAFLSLFRKYISNFDKHTTQLNEIALQILPFDFIASLTSIVTPSQLDYLRLAFEVYSRCPPKSRSSDILSCAPPFTLAKSIPKIVPFKLALDPGSPLTERHSLHIAYSKSLDQRWVTTAWTDNLGRDQLTMTYCLREKNSNISRPMSEIRADIWDVTRHIIGKSHAYWRVMVVTDEPVELNETEAWISLAQHHNQTNATKIELTLLSVNVKPCLYLKLPSPPLQISTYTGPTSSTPASTPNPGIPSPDPSAAAPTPPPSSAEQAQTPVPQSFDTPDSETILVDKSDETWSITLSHRLNTSPSLTSYHSALASGYLIRRRGGTSNTDGIASLCVNVVFTHARIPTELLLKDILRMYRDLAALARTKGIIHAQGDDVLPWHISTVVRGREFLSLVL
Length1231
PositionKinase
OrganismUncinocarpus reesii (strain UAMH 1704)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenaceae> Uncinocarpus.
Aromaticity0.09
Grand average of hydropathy-0.350
Instability index47.69
Isoelectric point5.00
Molecular weight136042.28
Publications
PubMed=19717792

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25755
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.71|      25|      25|    1055|    1079|       1
---------------------------------------------------------------------------
  206-  225 (31.22/10.10)	......SAVYPTPPGGVTGAGFTPVP
 1055- 1079 (45.24/17.76)	LPSP.PLQISTYTGPTSSTPASTPNP
 1081- 1106 (45.25/17.76)	IPSPdPSAAAPTPPPSSAEQAQTPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.27|      32|     168|     674|     711|       2
---------------------------------------------------------------------------
  674-  711 (46.40/43.70)	SSFDlkRYTSIDDENSMQGLRKDFryatVGSLSKLDSP
  849-  880 (55.86/34.89)	SNFD..KHTTQLNEIALQILPFDF....IASLTSIVTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     349.66|     105|     168|     282|     449|       3
---------------------------------------------------------------------------
  246-  330 (77.93/29.55)	.........................................................................PGPVSAGLSQTGYRATPTSLPAVdatapaleigsgmYDTtvdDNPFDEMDDNLEAKEVTEADFNFFDEPDFTNFPGegMEMSLQN
  354-  491 (122.80/115.89)	VGLPPLSAEEQEggyntesgeqslvsppakviiqenlgelndGSSYEPVIPHRPLSpmnirDILSTSCLSSLSPNPSSPSGRTTKGKSRTGYEPIL..frenlnfsdgkYRL...DGKFWFLPEVKSPKPSDRAAMNLSD......IPT.........
  492-  577 (148.93/60.20)	VGIPQWPNKEQR..............................HLSWESTAGNRSEG.....DVQSSSISSNQSCDDDSEPGNISPDRCDTGLRLFL..................................GTKDNSQLFKDKDFTPSP...MELSTVN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.78|      22|     650|      76|     143|       4
---------------------------------------------------------------------------
   52-   74 (40.35/33.78)	PLYPkEW.........KVAVYRHLQGFGLCLD
   89-  119 (38.44/57.58)	PLEP.QWagsgaenqsSVAYKRFLWPARLCFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.78|      26|      29|     780|     808|       5
---------------------------------------------------------------------------
  780-  808 (42.55/33.59)	SRPRGSKGLISWGLDPIggrEYPAVMRDV
  811-  836 (46.22/27.58)	SLPPGGETIVIYIVNPF...PYEAAIVDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.52|      13|      25|     906|     918|       6
---------------------------------------------------------------------------
  906-  918 (23.23/11.77)	LSCAPPFTLAKSI
  928-  940 (23.29/11.82)	LDPGSPLTERHSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25755 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DKPGPVSAGLSQTGYRATPTSLPAVDATAPALEIGSGMYDTTVDDNPFDEMDDNLEAKEVTEAD
2) ISTYTGPTSSTPASTPNPGIPSPDPSAAAPTPPPSSAEQAQTPVPQSFDTPDSET
3) NFFDEPDFTNFPGEGMEMSLQNTNDLFEDPPEALQAETLQPVDNAVGLPPLSAEEQEGGYNTESGEQSLVSPPAKVIIQENLG
4) WPNKEQRHLSWESTAGNRSEGDVQSSSISSNQSCDDDSEPGNI
244
1062
309
497
307
1116
391
539










Molecular Recognition Features






MoRF SequenceStartStop




1) YLIRRR
1151
1156