<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25742

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMVPSAGPGPPGSAGSISLGMLVDFIIQRTYHDLTVLSELLPRKTDMERKIAIVQFAHRTRQLFVRLLALVKWANSAAKVDKCAMISAFLDQQAMIFVDTADMLYRMVRELVHARLPSFNIPHAVDVLTTGTYPRLPKCIRDRIVPPDPITPAERKATLLRLNQIIQHRLVTTDLPPQLGNLTIANGRVKFQVSHEFEATLTLMGDEPSIPWRLLGIKILVEDKDTGNGTALVHSLQVNYIHQLIQSRLFADDRPLYDLYDCLHSFCQSLQLEVLHSQTQRLIHERWSDHIRLEEYTIGQSLTVSYWRAQLVEAAQNKLEIPVTHKLTIAMHDNDKSRPLQVKHQPPLPSHEPVQVDHAIKSDCLSMEKLLVQTVQARAYARLKELQLQIKAHNRDDQSLICGIPPVLKIPILYPCTEVEYMNIVADLQTGMLQPMFYHGESHLEEMEKNINSDASRTIRMVSDLRFVIARRRCQHTVLHLPTVCHRKLHLENFQTHPISKLSSHKVYLRLTRHPGYYLVVEFLEGQQFYEIEYRYHLLQLKDPGGKSEGESSDSAVSSHAGSLVTLDPATFSKEVGTATPGIKRKVCALKRERVDAGEPSMYLPDVAHLISVCDTQIPLISLCQELGRRGIPCQGVQSEGYDVGLSVKLLALPSLRGIPDHVVFKLKSDCLGCTFRLQGKTSRVWIAELVFANCPLVSTTQREQTSSRHVYFTYDGLKPESEASTSNNTENANITLVMDKFMQDWHSIAEMYATVLDFARNYKDPNRQLFQMVEVKSFSYKRLTLSYGVGRSSTVKIQWVPEGNGGSFKLGLGMVGRVNNPNCHMVVQSQLQEEFNTHHNIAQLIQVLCETQSPLQSIIRLPQTTILGCPNKPLSPTQTFTILPQSSDHVRIAFRNIYCLDVHCRGRNLVAIRDGAYSLFDVSKVVEGFTPTQGLKAFLSMFEDSMAHSRRRSASEDDNPPSPIGMSCIPTICTSSPPQLTPQHPNPGAPITSAPTPSPSMLYGTPSPSTFTSSSPSVRVPSPSSFVPAPSPQSMGIHMGPSPAFMNPTGKFTHSSLSPPSPFHAGLTMPSPGTRNPWPGSPSMPGPSPASRVGMASPGKPPNHSLIGNMTHCHSPIGVGSSMLSPPSRILPQRSWAASIPTLLSHEAFATLMTPSPPPGVMGGPAAYLCCPLERFLGCVYMRRHLQRVIQGEESLHLLQSSEPGVILYHVESINFRVQLNPSTLQTLHLKATPRPEAMEMWSREELNILESFFDTKVVCPPYKANTLTAFGRLLCAPTAVLRDCIQLMRLELFPDQALKWHLQWCLTIPPSGSPLAPPGTPAVVIRTKILFFIQLTRMGMPPTQDSTVVVPILYDPSSNTTQQADISNRAGATGGPAPPNALSGMVGDMLKRWASFSQGQQGNDCTIFPAIRDLLHNLIPQCQ
Length1424
PositionTail
OrganismBranchiostoma floridae (Florida lancelet) (Amphioxus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Cephalochordata> Leptocardii> Amphioxiformes> Branchiostomidae> Branchiostoma.
Aromaticity0.07
Grand average of hydropathy-0.182
Instability index55.01
Isoelectric point8.58
Molecular weight158097.56
Publications
PubMed=18563158

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25742
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.07|      21|      23|     985|    1007|       1
---------------------------------------------------------------------------
  985- 1007 (40.18/18.74)	PNPGAPitSAPTPSPSMLYGTPS
 1077- 1097 (41.90/15.34)	PWPGSP..SMPGPSPASRVGMAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.57|      19|      24|     131|     151|       2
---------------------------------------------------------------------------
  131-  151 (34.98/26.14)	TYPRLPKCIRDRIVPPD.PitP
  157-  176 (30.59/16.25)	TLLRLNQIIQHRLVTTDlP..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     153.86|      24|      24|    1015|    1038|       3
---------------------------------------------------------------------------
  950-  967 (23.29/ 6.43)	....RRR....SASED....DNPPSP..IGMS
  969-  984 (27.93/ 9.29)	IPTICTS....SP........PQLTPQ....H
 1015- 1038 (45.52/20.17)	SPSVRVP....SPSSF....VPAPSPQSMGIH
 1042- 1068 (33.60/12.80)	SPAFMNPtgkfTHSSL....SP.PSPFHAGLT
 1140- 1163 (23.52/ 6.57)	IPTLL......SHEAFatlmTPSPPPGVMG..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.04|      11|      24|     853|     863|       4
---------------------------------------------------------------------------
  853-  863 (20.66/ 9.71)	SPLQSIIRLPQ
  875-  885 (20.37/ 9.48)	SPTQTFTILPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.28|      15|      27|     771|     791|       6
---------------------------------------------------------------------------
  771-  788 (23.22/17.01)	QMV.EVKSFSYKrltLSYG
  798-  813 (24.05/13.34)	QWVpEGNGGSFK...LGLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.30|      13|      23|     410|     422|       7
---------------------------------------------------------------------------
  410-  422 (25.80/18.44)	PILYPC.TEVEYMN
  434-  447 (21.51/13.90)	PMFYHGeSHLEEME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.17|      26|      92|     211|     237|       8
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  211-  236 (43.33/33.41)	W..RLLGIKILVEDKDTGNGTALVH....SLQ
  239-  270 (35.84/20.91)	YihQLIQSRLFADDRPLYDLYDCLHsfcqSLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.59|      17|      23|     669|     685|       9
---------------------------------------------------------------------------
  669-  685 (32.96/25.18)	DC..LGCTFRLQGKTSRVW
  693-  711 (25.64/17.61)	NCplVSTTQREQTSSRHVY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.15|      26|     346|     918|     944|      10
---------------------------------------------------------------------------
  918-  944 (43.00/33.39)	SLFDvSKVVEGFTPTQGLKAF...................LSMFED
 1252- 1296 (38.15/24.22)	SFFD.TKVVCPPYKANTLTAFgrllcaptavlrdciqlmrLELFPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.95|      18|     347|     472|     501|      13
---------------------------------------------------------------------------
  483-  501 (29.86/38.43)	VCHRKLHlENFQT.HPISKL
  826-  844 (27.09/ 7.33)	VVQSQLQ.EEFNThHNIAQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.73|      10|      23|     537|     547|      16
---------------------------------------------------------------------------
  537-  547 (13.96/12.24)	LLQLkDPGGKS
  563-  572 (17.77/ 9.97)	LVTL.DPATFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.01|      23|      23|     317|     339|      17
---------------------------------------------------------------------------
  317-  339 (38.37/23.53)	KLEIPVTHKLTIAMHDNDKSRPL
  342-  364 (38.64/23.76)	KHQPPLPSHEPVQVDHAIKSDCL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25742 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ICTSSPPQLTPQHPNPGAPITSAPTPSPSMLYGTPSPSTFTSSSPSVRVPSPSSFVPAPSPQSMGIHMGPSPAFMNPTGKFTHSSLSPPSPFHAGLTMPSPGTRNPWPGSPSMPGPSPASRVGMASPGKPPNHSLIGNMT
972
1111










Molecular Recognition Features






MoRF SequenceStartStop




NANANA