<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25728

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMADNNADWRSPAFRQKVMAQIDDAVRAAGNPTSKSSMEMENHVFQKAKSRVSRIPVCVEVCMGLCVCGETKKDQQRQGGGPQQDPMNALQNLTSLSQGQPSQQAMQMSQPSQLALQSQLAQSTQQAMQQQMSQQQQFQQQPPPQQFQQSQQPFQHSQQAFQQSQQPFQTSQQPLPPQPPQPGGQARMGPTMQQQQQQAQFQAQQRQQFQGQTRAQLVQQQIQQRLQQQQQLQQQQQQQQQQQQQQQQQQQQQQNLMQQQLQQQQLQQQQQQQQLQQQQLQQLQQKQLQQQKQQQLQQQQQQQQQQQQQQQQQQQSQQQQMMKQRPALQRQQNIGGLLSPSQQLQGQSPGSVQVASPAQSSAMQRPVASPAQTSSMQRQVASPAQTTTMHRQVASPAQTGSIQRQVASPAQPGSMQRQVASPAQPGSVQRQHTPQSGSQSAASPATMLPSPSPQPSMAPSPASATARTPAGVQSPVSLNTPGNPGSVGMAASPRNPTEEQAYLEKWKQLSKYIDPLQRMIKRVSNTDEHKKDLSKMKNLLEILTDQKKRLQYQTLLKCEQVLEKLELQMKMSHTTSTTTTTTTTTPAQLPKSQQHMCQPLLDAVASQLGSPMLNHTLKRTFGPALTALHGPPICFPGPPPKRQRIIPRQEYSIPNILQGEVAKLDQKFKVSLDPTQNNISTSVHLVCRLVCLPSSWSCLSSTQKKAHNAQQSHMIMTVKKSLDLRLLKLPDQHSLTQLLGAWEMSVRQACKEAVAITT
Length757
PositionTail
OrganismBranchiostoma floridae (Florida lancelet) (Amphioxus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Cephalochordata> Leptocardii> Amphioxiformes> Branchiostomidae> Branchiostoma.
Aromaticity0.03
Grand average of hydropathy-0.982
Instability index91.85
Isoelectric point10.11
Molecular weight84778.62
Publications
PubMed=18563158

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25728
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     521.26|      63|      63|     191|     253|       1
---------------------------------------------------------------------------
   69-  125 (59.46/ 6.42)	..............ETK.KDQQRQGGGP....QQDPMNALQ...NLTSLSQGQPSQQAMQMSQPSQlalqsqlaQSTQQ
  127-  181 (90.21/16.18)	MQQQmSQQQ...QFQQQpPPQQFQ.........QS.QQPFQ...HSQQAFQQSQQPFQTSQQPLPP........QPPQP
  191-  253 (124.44/27.05)	MQQQ.QQQA...QFQAQ.QRQQFQGQTRAQLVQQQIQQRLQ...QQQQLQQQQQQQQQQQQQQQQQ........QQQQQ
  256-  309 (102.96/20.23)	MQQQ.LQQQ...QLQQQ.QQQQ.......QLQQQQLQQ..L...QQKQLQQQKQQQLQQQQQQQQQ........QQQQQ
  312-  365 (73.05/10.74)	QQQS.QQQQmmkQRPAL.QRQQNIGG............LLS...PSQQLQGQSPGSVQVASPAQSS........AMQRP
  375-  438 (71.13/10.13)	MQRQvASPA...QTTTM.HR.QVASPAQTGSIQRQVASPAQpgsMQRQVASPAQPGSVQRQHTPQS........GSQ..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.04|      21|      21|     525|     545|       2
---------------------------------------------------------------------------
  503-  521 (26.07/12.60)	..EKWKQLSKYIDPLQRMIKR
  525-  545 (32.42/17.21)	TDEHKKDLSKMKNLLEILTDQ
  547-  567 (30.55/15.86)	KRLQYQTLLKCEQVLEKLELQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.40|      30|     137|     443|     499|       3
---------------------------------------------------------------------------
  443-  475 (52.26/16.43)	PA.TMLPSPspqPSMAPSPASATAR........TPAGVQSPV
  622-  660 (47.14/25.62)	PAlTALHGP...PICFPGPPPKRQRiiprqeysIPNILQGEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.25|      14|     137|     587|     602|       4
---------------------------------------------------------------------------
  587-  602 (23.00/15.66)	QLPksQQHMCQPLLDA
  727-  740 (23.25/ 9.70)	KLP..DQHSLTQLLGA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25728 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KKDQQRQGGGPQQDPMNALQNLTSLSQGQPSQQAMQMSQPSQLALQSQLAQSTQQAMQQQMSQQQQFQQQPPPQQFQQSQQPFQHSQQAFQQSQQPFQTSQQPLPPQPPQPGGQARMGPTMQQQQQQAQ
2) MADNNADWRSPAFRQKVMAQIDDAVRAAGNPTSKSSMEMENHVFQK
3) QSQQQQMMKQRPALQRQQNIGGLLSPSQQLQGQSPGSVQVASPAQSSAMQRPVASPAQTSSMQRQVASPAQTTTMHRQVASPAQTGSIQRQVASPAQPGSMQRQVASPAQPGSVQRQHTPQSGSQSAASPATMLPSPSPQPSMAPSPASATARTPAGVQSPVSLNTPGNPGSVGMAASPRNPTEEQAYLEKW
71
1
314
199
46
505










Molecular Recognition Features






MoRF SequenceStartStop




NANANA