<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25726
Description |
Mediator of RNA polymerase II transcription subunit 1 (Fragment) |
Sequence | SNKDEKSEELSALMQRLRTKSAQIKSWSDTSKLVRSAMDKRAVDNMDHSRLRKCINALQKALKVTTLPSMVERLDSVARQVGLNFKVSSSGHECCISSELFYVEIRLDTSGGVQDVRVAHHGSESQGCLEMLRVLRNGDFKEFVGHLKGLLNIYRIPGDSKIKMRTYQTLLCMESDLTKMADAYKMSGGRGDPMTQIQKGIVGYVIPRQGGHPMQLKCFISPYDMLNVEREKSETIHDNVPRDVGQSVNVVLEGSTSHKLQTQPLFAGINPPQHDSKGSPAFAGINNNNMMLLPACFSLVPPSPIPLSISTIKRIHSATGILCGDESKAVPMNRLVTQNVMEAKGIADMDNNNGRNKLFHVTLPDQHHSYYINDAPDLKGVLVSKIPFTHPACVPRVLEALRQQTVYNTLITSCVRKGCEEAKENAQLFEVNTTSPTGISVTFEHPVQESMACLEIDLADPNHVKCKVHIPAGDAPVCTDEYATMVMNRCLSIPVLMRAIARHA |
Length | 504 |
Position | Middle |
Organism | Branchiostoma floridae (Florida lancelet) (Amphioxus) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Cephalochordata> Leptocardii> Amphioxiformes>
Branchiostomidae> Branchiostoma.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.287 |
Instability index | 41.82 |
Isoelectric point | 8.41 |
Molecular weight | 55717.58 |
Publications | PubMed=18563158
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP25726
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 74.37| 21| 92| 265| 285| 1
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265- 285 (39.78/17.53) LFAGINPPQHDS...KGSPAFAGI
358- 381 (34.59/14.61) LFHVTLPDQHHSyyiNDAPDLKGV
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 49.58| 13| 18| 191| 204| 6
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191- 204 (21.46/14.85) GDPMtQIQKGIVGY
211- 223 (28.12/15.28) GHPM.QLKCFISPY
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|