<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25720

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMFPTPPSVNPSLSPCNAGNQEYTSPDSVPGITKADGHAATALADYPEVEVDESMGSPVPEQIKDWSYVYRKANTHLHCGSSMYAPLKSLPSHKLPPIRLKDNMLYKPSWQVCLEKGNTDVDVMTFLQMPVKDYPTVTAGGFMDLMPLPQDMINSTCPITMTTVTASNSVPMASPAFASVKTPRSAGGPGPYDSPPSTVSSFRNVNSVDMNSVGPTMEAHSLTVNMLLSDSAINLFKDRNFDSCVICVCNVNIKGADVEVYLPEFHAQNQEAQYKCTCGFSAVMNRKYARKAGLFPEDLCEIFGFKNVKRLKDNVSEVNRTSREGDSAQSGKTDEKATLNMKLAGNNRISKALLQKTNDCTVHSSVMCFLPDDCDACHWALEQGRSHDGSPVKLEQADKAVCQHTWPPPKAVDQSSLSSRDVVRMLQSLQPLLQDAIQKKRTTRLWEPKPTVQGPLTWSQFHRLVGRGTQAYLNSSEPLPVPSLLVGYEKDWLSLSPFALNHWEKLLLEPFGTSRDVVYVVICPDNDTILSNAKAFFRELSTVYESCRLGRHRPITTVLRDGIRRVGKVAAERLADKPVDEWFNKLGQSPSLSKLKLYAQVCKHDLAAHLATVTLDTSLLKALPTPGKNSVTSNSSNSTTGTSSSGNTDKPPSVPPPPSSGDGKEGESPKDPNNTGGESSEGGQNKENKDGSPDEVDEEAQPLAVVVYIVDPFSMGPENGHLTDVYALGLLKCYTEILQADLPDNVRNNISLQIIPVQQLVQPQKAEERATYLQHLKTLAFSVFTQSHRTLQFTIHAKSVTGFGPSAQNEAILKSKETDVLHLYTPPYILAPQKDKQTELVESFGELTPKSGVLFCAYCLSSDQRWILATVTDLRGELLDTVVISVEAPISPKPRKVSACRMGLQKLWEFVLSVIATTTFPWRIVIGKLGRIGHGELKDWSSLLSRQRILKSSRNLKEVCRMCSMSPQCECPTILSACMVSLEPESALRIFHESVMSGSAPGARPGGLLGSQLSTPRDASCTHLMAFPTSATTQAAAANFSITETMDLGFAGNTGDMLGDDDLLPVLQEDLGDSDLNQFLGLAASPTALTSPVHSPQSPTGGGFSGGGQSNPYSGGGDGSGKPLPDPDEIPMLLQQPLALGYFISTAPIGDMPKSFWSACPHAEGVCPVYLKSALHVHTPAVQQNSEEILQSRHSHPLDSNLTCDVLRYVLESYNALSWLTYDPVRRDRRSCLPVHMVVLTKLYNTMATLLT
Length1251
PositionMiddle
OrganismBranchiostoma floridae (Florida lancelet) (Amphioxus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Cephalochordata> Leptocardii> Amphioxiformes> Branchiostomidae> Branchiostoma.
Aromaticity0.06
Grand average of hydropathy-0.294
Instability index51.38
Isoelectric point6.00
Molecular weight136285.35
Publications
PubMed=18563158

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25720
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     375.90|     120|     134|     708|     839|       1
---------------------------------------------------------------------------
  710-  839 (190.16/143.12)	DPFS.MGPENGHLTDVYALG.....LLKCYTEiLQADLPDNVRNNISLQIIPvqqlvQPQKAEERATYLQHLKTLAFSVFTQSHRTLQFTIHAKSVTGFGP....SA..QNEAILKSKET..DVLHLYTppyiLAPQKDKQTEL
  841-  974 (185.74/111.66)	ESFGeLTPKSGVLFCAYCLSsdqrwILATVTD.LRGELLDTVVISVEAPISP.....KPRKVSACRMGLQKLWEFVLSVIATTTFPWRIVIGKLGRIGHGElkdwSSllSRQRILKSSRNlkEVCRMCS....MSPQCECPTIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     218.20|      70|     135|      13|     122|       2
---------------------------------------------------------------------------
   13-   94 (108.39/67.39)	SPCNAGNQEYTSPDSVPgitkadgHAATALAdypEVEVDESMGSPVP.EQIKDWSYVYRKANT.HLH.CGSSMyAPlKSLPSHKL
  154-  226 (109.81/71.93)	STCPITMTTVTASNSVP.......MASPAFA...SVKTPRSAGGPGPyDSPPSTVSSFRNVNSvDMNsVGPTM.EA.HSLTVNML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.50|      31|     300|     370|     400|       3
---------------------------------------------------------------------------
  370-  400 (59.07/37.12)	PDDCDACHWALEQG....RSHDGSPVKL.EQADK.AV
  668-  704 (41.43/23.62)	PKDPNNTGGESSEGgqnkENKDGSPDEVdEEAQPlAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.86|      38|     446|     605|     662|       6
---------------------------------------------------------------------------
  619-  662 (62.70/49.36)	LKALPTPGKNSVTSNSSNSTTGTSSSGNTDkppsvpPPPSSGDG
 1081- 1118 (72.16/26.12)	LAASPTALTSPVHSPQSPTGGGFSGGGQSN......PYSGGGDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     309.07|     100|     501|     470|     582|       7
---------------------------------------------------------------------------
  470-  582 (144.83/99.36)	AYLNSSEPlpvPSLLVGYEKDWLSLS.PFAlNHwEKLLLEPFGTSRDV..VYVVICPDNDTILSNAKAFfrelsTVYESCRLGRHRPITTVLRDGirRVGKVAAERLADKPVDEwF
  976- 1078 (164.24/79.90)	ACMVSLEP...ESALRIFHESVMSGSaPGA.RP.GGLLGSQLSTPRDAscTHLMAFPTSATTQAAAANF.....SITETMDLGFAGNTGDMLGDD..DLLPVLQEDLGDSDLNQ.F
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25720 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TALTSPVHSPQSPTGGGFSGGGQSNPYSGGGDGSGKPLPDPDEI
2) TSLLKALPTPGKNSVTSNSSNSTTGTSSSGNTDKPPSVPPPPSSGDGKEGESPKDPNNTGGESSEGGQNKENKDGSPDEVDEEAQ
1086
616
1129
700










Molecular Recognition Features






MoRF SequenceStartStop




NANANA