<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25711

Description Histone acetyltransferase
SequenceMQGPGNGASGPQPVGGMPSQGSAGTQWKTWQSDADIPQRKVLIQHILKLFRQRKPSETREWQQKLPDFVLRLEEAVYRGARSKEEYCNEATLEARLQAVARIMVARPRQGGGAQQPGGGVGRVGGVGGQPTMQMVQPGGQPGTGGMQPNPNDPNMMMQMKQDPGGMMGGGGMGGMIMSNGAPVIRGAAAQGVSVGNVAMKGPGGMTAAQQQQMMMQQQQQQQQAMMMQQQQQAQQRAAAMAAAGVNVKPGKKPTKAQEAQIAKHQKAQQAAMIAQQQQQQQQAMMAGGGRGGMGGRGGMGGRGGGRGAPQQAQAANGGQPMTEDQIKKAYIVKQQRWLLFLRHASKCQAPEGKCQLTQQCHVAKDLWKHVLQCLNPRCEYPRCIASRELLKHHQNCKDARCPVCGPVRSAMIKQRSHAMMQAQQQQMQQQGGPAAKRARMDGGVMMPPPTQVKGTVGTKRPGGEGTSLMECFSPEEVRTHLASLRLADKDVTAAKGQPMSARRRDAESEKAIAGATESACQACGVERLTFEPPPLYCYACVGRIKRGQVFYHIPPHVTGGEVRKDAWCNPCYNQIQGSIEVEGVKYPKNQLAKKKNDDDLEEPWVQCDYCNCWYHQICVLFNGRKNTGGEAPFTCPSCILSQLDKKERAPTTNRPSSQLPASELPHTRLSFFLEERLKKVMTHERNERAKLLGKPIEEIPAADGLVIRVVSSVEKTLEVKKNFKDAFKDQNFPERFPYRSKVLLLFQKTEGVDVCLLGIYVQEYGSDCPAPNNRRVYLSYLDSVKYFRPSGIQVATGEGCALRTYCYHQILIGYLQYIKQRGFTSCFIWACPPFQGEDYILYCHPKEQKTPKSDKLREWYLKMLRQAQKEGIVLSLQNLYDEFHLGNQNHDIASATELPYFDGDYFPGVAEDWIPGIQKEQAELAKKNKGKSAKQTTATARKTGKGKRLGVGTPEAELDVELMKKLGTTIHTMRHDFIMVHLAHQCTQCRKCIADDNRWYDSTPSASGAAFELCQECYDVEQALESHEKKLTTGRDLVCERVDPLPDVKESDEVINSEFFDTRQAFLSLCQGNHFQFDSLRRAKHTTMMVLYHLNNPSEPAFVATCNSCQRELEPGKGWRCETCPDFDICDDCKRMKGHEHPLVRSGGRSDRGPGMTEEDRRVRAEQIQRTMELLVHATRCKDANCGSPNCTKVKHLFKHAANCQLKAAGGCQLCRKMWTLLQVHANGCNDANCPVPRCKDLKAYRQRSQEQQDAKRRARYRVYMQEQQTGA
Length1272
PositionTail
OrganismMicromonas pusilla (strain CCMP1545) (Picoplanktonic green alga)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Chlorophyta> Mamiellophyceae> Mamiellales> Mamiellaceae> Micromonas.
Aromaticity0.06
Grand average of hydropathy-0.673
Instability index47.22
Isoelectric point9.11
Molecular weight141566.51
Publications
PubMed=19359590

Function

Annotated function Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation. 
ECO:0000256	ARBA:ARBA00002581
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-KW
GO - Biological Function
histone acetyltransferase activity	GO:0004402	IEA:UniProtKB-EC
transcription coregulator activity	GO:0003712	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro
GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25711
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     180.28|      44|      44|     201|     244|       1
---------------------------------------------------------------------------
  129-  159 (33.63/ 9.41)	........................QPTMQMVQPG......gqpG.TGGMQPNPNDPNMMMQM
  160-  218 (57.37/21.19)	KQDPGGMMggggmggMIMSNGAPvIRGA..AAQGvsvgnvamkG.PGGMTAAQQQQMMMQQQ
  219-  265 (59.22/22.11)	QQQQQAMM.......MQQQQQAQ.QRAAAMAAAG.......vnVkPGKKPTKAQEAQIAKHQ
  266-  289 (30.06/ 7.64)	KAQQAAMI.......AQQQQQQQ.Q..AMMAGGG............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     164.79|      22|      22|     360|     381|       2
---------------------------------------------------------------------------
  360-  381 (41.48/24.33)	CHVAKDLWK....HVLQCL...NPRCEYP
  383-  402 (38.83/22.22)	CIASRELLK....HHQNCK...DARC..P
 1173- 1189 (24.77/11.02)	.....ELLV....HATRCK...DANCGSP
 1191- 1213 (26.14/12.12)	CTKVKHLFK....HAANCQlkaAGGCQ..
 1215- 1237 (33.57/18.04)	C...RKMWTllqvHANGCN...DANCPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.63|      20|      39|     644|     663|       4
---------------------------------------------------------------------------
  644-  663 (34.41/24.44)	DKKERAPTTNRPSSQLPASE
  684-  703 (33.21/23.29)	ERNERAKLLGKPIEEIPAAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     225.30|      57|     115|     974|    1031|       5
---------------------------------------------------------------------------
  974- 1030 (105.37/63.58)	RHDFIMV..HLAHQ........CTQCRKCIADDNRWY.DSTPSASGAAFELCQECYDVEQALESHEKK
 1032- 1068 (43.84/22.74)	.......................TTGRDLVCE..R.V.DPLPDVKESDEVINSEFFDTRQAFLS....
 1084- 1142 (76.09/42.79)	KHTTMMVlyHLNNPsepafvatCNSCQRELEPGKGWRcETCPD.....FDICDDC....KRMKGHEHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.59|      26|     192|     609|     636|       6
---------------------------------------------------------------------------
  522-  554 (36.76/18.15)	ACGVerltfepppLYCYACV...GRIKR.G.QVFYHIP
  570-  587 (21.07/ 7.50)	PC............YNQI....QGSIEVEGvKYP....
  609-  636 (49.76/32.86)	YCNC.........WYHQICVlfNGRKNTGG.EAPFTCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.01|      17|      24|     430|     453|      11
---------------------------------------------------------------------------
  431-  447 (31.96/ 9.65)	GGPAAKRARMDGGVMMP
  454-  470 (29.04/14.16)	GTVGTKRPGGEGTSLME
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25711 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAQGVSVGNVAMKGPGGMTAAQQQQMMMQQQQQQQQAMMMQQQQQAQQRAAAMAAAGVNVKPGKKPTKAQEAQIAKHQKAQQAAMIAQQQQQQQQAMMAGGGRGGMGGRGGMGGRGGGRGAPQQAQAANGGQPMTEDQI
2) AVARIMVARPRQGGGAQQPGGGVGRVGGVGGQPTMQMVQPGGQPGTGGMQPNPNDPNMMMQMKQDPGGMMGGGGMGGMIMSNGAP
3) MQGPGNGASGPQPVGGMPSQGSAGTQWKTWQ
4) QRSHAMMQAQQQQMQQQGGPAAKRARMDGGVMMPPPTQVKGTVGTKR
187
98
1
414
326
182
31
460










Molecular Recognition Features






MoRF SequenceStartStop




1) RKVLIQHILKL
2) VYMQE
39
1263
49
1267