<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25709

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMQGLPRHTPTVSLTELVDRVVHASYGELTSLANALPGQPEPDRRRELARFLHVTKQRLARLGAIAEWAPVQRRAQISVTCGDMLGQLAQHDAAFTDGADRLFALHSQLAWAKAPLYDLPGALDVLCRGRYTDMPHAAFEEVKNAPKAAAAREGAPKTEAQVAEEAKQQRAKEDREKRFNAEIRGRLLEVEAGVATGGTKPRAMKVWEISRGQAIVGVPGEYRAVLTLGGPPPLPPPPPEPAEGEEPPPPPPPPPPPPLGGWLVERIEILVGERDVDTDETRRFELSAQETRVLSERSTARMAGMSPPPPAPPERVEGGAQSLNGLHYVCHGAALKLAAAAVMEQSKRLASGSAKRWTGGGIRTEPIKNDAAATKFGGGKGVRMWFWIPERSAGHGTGTQLAGVGVGSVEAVAATTAAVDAAVAAGTLPRVDVVYTAADENDSSSGVIAATAAVPASDASPAPAPAAGKDGEAATSPPEVETTELTFDTATVDVRRLLEDGMRAAATARLNAALKAVAKPCKQAGLTVTFDPDAVNDLGENEDGWGIARRPAIVANLGASGNYVVSISCSKRSGKLSLCGAGGLVSPAVAAAAAARLLKSGVDAIQPLLEKMRRAAFERDLRDAIAAEGMRPHETPRAILASDDVWPSDLAERPLAALVPISPSSGGLYVGVFVGSEDEKGKPGKTSFALIQTKRPNAASKPRVVSCAALDATSGSILPSKKRKAGDTGAAQGTAKTYEAFDVVHAARVVKLAVEKETVTAQRTAAAAWLKRRATRFGDSRLVGGDAAASGLSCPVIAFTVKDATAELELRGADGVYIVVRALGPFEGCAVAKEKENEGEPAPAGASGGGAASAETEKDGSAVVTAAYPASEFAVGAALADAYRTIASLAFARAMKGTSSSLTVEIEPFSVVIARGKGKDATRARVGWVGAPGPGGRLIAAAAGAQGSMTPETEAALSEAARAGDVDAFARALEGAGK
Length977
PositionTail
OrganismMicromonas pusilla (strain CCMP1545) (Picoplanktonic green alga)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Chlorophyta> Mamiellophyceae> Mamiellales> Mamiellaceae> Micromonas.
Aromaticity0.05
Grand average of hydropathy-0.174
Instability index40.85
Isoelectric point6.88
Molecular weight100956.10
Publications
PubMed=19359590

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25709
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.83|      14|      16|     230|     243|       1
---------------------------------------------------------------------------
  236-  252 (29.83/ 9.87)	PPPEPAEGeepPPPPPP
  296-  309 (26.00/ 7.70)	RSTARMAG...MSPPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     333.47|      75|      75|     820|     894|       3
---------------------------------------------------------------------------
  457-  513 (67.76/23.76)	..................D.........ASPAPA.....P...AAGkdGEAAT.SPPEVETTEL...TF....DTATVDVRRLLEDGMRAAATARLNAAL
  535-  595 (56.06/18.38)	NDLGENEdGWGIARR.................PAivanlG...ASG..NYVVSiSCSKRSGKLSLCGAGglvsP....AVAAA..AAAR...........
  820-  894 (125.92/50.52)	RALGPFE.GCAVAKEKENE.........GEPAPA.....G...ASG..GGAAS.AETEKDGSAVVTAAY....PASEFAVGAALADAYRTIASLAFARAM
  903-  972 (83.73/31.11)	VEIEPF..SVVIARGKGKDatrarvgwvGAPGPG.....GrliAAA..AGAQG.SMT................PETE....AALSEAARAGDVDAFARAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.92|      32|      75|     676|     718|       7
---------------------------------------------------------------------------
  627-  667 (44.99/11.09)	EGMRPHETPRAILASddvwpsdlaERPLAALVPISPSSGGL
  678-  709 (54.94/34.10)	EKGKPGKTSFALIQT.........KRPNAASKPRVVSCAAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.74|      24|      55|     722|     745|       8
---------------------------------------------------------------------------
  722-  745 (42.83/28.66)	RKA...GDT......GAAQGTAKTYEAFDVVHA
  771-  803 (30.91/18.08)	RRAtrfGDSrlvggdAAASGLSCPVIAFTVKDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.53|      14|      54|     200|     216|       9
---------------------------------------------------------------------------
  185-  200 (19.00/14.28)	RLLEVEAGVATGGtkP
  204-  218 (21.53/ 6.47)	KVWEISRGQAIVG.vP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25709 with Med14 domain of Kingdom Viridiplantae
Unable to open file!