<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25706

Description Bifunctional polynucleotide phosphatase/kinase
SequenceMHELLLFASVPAKQHHDLLQQLSGLTAMQPTRTFERHLIFKAYRKPGFIKTRPGGSQDVQAPEVQRLNKLLNGGLYYTQVVGNVRERDFGSVPPPSSVSASASASQPRADDSAQAQEASSLMNGTAPATVEGGYVAADQQSWRLEFKDTPEAGQRPAVTSRFVGSAKLPSGNILAEMKAWGFDFVSEYVLEGHTFILDDTVLLVHRVLTFPPGNAGCGGGGSEATSTPTSYLPPLDKMVPLDSSGAYVLQASITVKESGNPDMLKTNSQRLLGLKERLKFVVKLEPADRLSLDTRLNAGPVFPYIRSIMTGTKRIIPDGAISPPPSKRTATGAVTNNRTLSDFFTPLSQKKPDITTWRIVNNSCVVGKYHSEQAAEAVKSGSKRRVAAFDLDSTLIATKSGRRFATNENDWKWWNPNVPKKLKELNDEGYLVVVLSNQKGISLKKDLKGGRLESKSLSIFKQKVAAVMQTLNVPFAVYAATENDEFRKPRMGMWREMVDDYDLDVCNSLDLKHSIFVGDAAGREGDHSCVDRDFASNVGILFKTPEEFFLNEDPKPIIRHFDPKAYIVGTSEDIHISFEKKNDPELVIFCGSPGSGKSTFYWRYLEPLGYERVNQDILKSRSNCLKAAREHLKVGNSVAVDNTNADSETRAYWIELAKEFSVPIRCIYLNTPLQICRHNDAVRSANPKMESLNPESRTALPGIAFGDFMRRFREPTLSEGFQDITQVEFKFQGESAAKEVWGQFWV
Length746
PositionHead
OrganismParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Paracoccidioides.
Aromaticity0.09
Grand average of hydropathy-0.399
Instability index34.59
Isoelectric point8.51
Molecular weight82746.86
Publications
PubMed=22046142

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
kinase activity	GO:0016301	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25706
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.75|      23|     351|     257|     279|       1
---------------------------------------------------------------------------
  257-  279 (38.54/26.35)	ESGNPDMLKTNSQRLLGLKERLK
  611-  633 (38.21/26.07)	ERVNQDILKSRSNCLKAAREHLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.27|      19|     110|     211|     255|       3
---------------------------------------------------------------------------
  217-  235 (37.51/53.67)	CGGGGSEATSTPTSYLPPL
  590-  608 (39.75/ 7.68)	CGSPGSGKSTFYWRYLEPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.13|      19|     227|      90|     108|       6
---------------------------------------------------------------------------
   90-  108 (33.97/17.71)	GSV.PPPSSVSASASASQPR
  319-  338 (30.16/14.98)	GAIsPPPSKRTATGAVTNNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     263.15|      86|     141|     350|     445|       7
---------------------------------------------------------------------------
  350-  445 (131.35/112.32)	KKPDITTWR.IVN....NSC.VVGKYHSEQAAEAVKSGSKRRVAAFDLDSTL.IATKSGRRFATNENdwkwwnpnvPKK.LKELNDEGYlVVVLSNQKGISLKK
  487-  580 (131.80/86.59)	RKPRMGMWReMVDdydlDVCnSLDLKHSIFVGDAAGREGDHSCVDRDFASNVgILFKTPEEFFLNED.........PKPiIRHFDPKAY.IVGTSEDIHISFEK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25706 with Med18 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DFGSVPPPSSVSASASASQPRADDSAQAQEASSLMNG
88
124










Molecular Recognition Features






MoRF SequenceStartStop




NANANA