<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25703

Description Uncharacterized protein
SequenceMPLRRPTSHPVSPSRVSAPSGSSAPQLVPLAPAPAPAPAPPPPARAIDPDVQVISVIDLTAESDTDRVSDDGSGPPAKRPCLDTRESSTPLVPRDNNQYLAIHQQPPLDPQHNTPSTASEVPESINPMDLMNHTPNEQSLRPPWSFRSGMSSSAARRASESSQWSQSAGLPLLPIRPWQYSPQERSPYHTPTASDAQKDDTWCLEVQTTPYRMSNPAKAPRFLDNKSADFSPWTGSQVEDVLSDHTIKHGFYDRVQVSPNESVSARSALYPQFKHRSGLKVLSSVFAASLEQRQNHNRVTAPSTFRPPPRVTLTDNKRETWLRDLANDSVPLRRLSRTIPHGVRGKVLLEHCLVKSVHISRALWVAKCVGANELRAFRRKGTSASVASGLEAKWVRDWTVNVQQFIEGVLGSLVDDSWKIRICYALRLTGRLFLEYLVDHDHFMEWFHTSSSKASLASFPVWLLMLGSYWDHVVKYRKRGKRLAECLLEKLSTAILINKNGHLNSLIRRLSRIIKKIVHHCPSSFILPRCWAKYETTLSSCLDMNSTEDKKDFAALQERNASISRVKVEPGPKDNSPLQHIIELLDSSSDIPTLATDLLNLSLDPSTVATTVLEWASTAFRYGISRTYTAVRLFRRWRRIGMDTDLYLFTFLAQAHQKSGVRLVDLYHIICELVRSQTFSVSKYLQWLIARGVLSSVSENKERMPGDIGLLSNLPSCRLPGHVWNLRNTLLSRTGFQVDLESETIEVVKQSIRRRLPTMFPEVRTDVNVQMTDDLDFSAVTWTVKCEIGQWLRDVVASHVRDSVRTVWDFTNDFGIVSLTHQEFFEVRYVLESLDDMSMFADVLKCASESDNVTVLISAVDALNYHLETFNAIGATPDLFKSLVSSYARIRTADSRIDHLITSLLEVGVRIPTEAPSVAMLRRDQMEREKQLSMEAPSPVSDDIADINTATPSRTFRHALDQLLASGNTMDEVTMTRIFNTLSKRLEYGSVNGKQCTHETARYFVRLRPFNTKLFDRLMIRWVITVLKSSPRPDLSSLLPPLIGVGCVALQSFYVLIKYLLRTGDLREGIPDLTEFRQSLIQLLDKRLANAGGAQDLVAYRFKIAQQEYVRLFPSQALSLLQDLLAGVSQATAESPKRAGGDPLGDSVKPLLSEIAVRHPHVLGMDGADRLLEKFPDCMKFTSQALSLLLTIPDGSVLDAAKETIASINDFSRPFCLMKLRLLFVESDIESKKRIYDLVFEAAKSDIQQGLSDWIHVVSTLHPDAAMEIRQRAEQQLLAITFTPLIAPPPALSSPIEPDAIATSDVSPLVYLRIVEELSFSILDAGNLSLGPVFVDKMNIMLQKITALENSIANTSSSQDTAQIDNLREAQAAQEISIRFWLYIMLRLIAIHRSDLDPSSLSKSDIVDQTRLLISISCIALSQTISSRNIPSVPLSPTLINISSQAANSLQTQALDVAAALVDTIPDEARHQCARFFRDRCPPYIHPQNQPRLLFLFGPIPPTDIAASFIPPKQPKQSSPASGAASSIPAAATATAAPAGPSTSTPAAVKGAEPAPTPESSQTLPTPPNSNYNAPSVAPSHMTPTTSISSFQPLPNPPSSVYNATSHIPCNDPNSFVGDLRLQQQGQDVGPFPLRPWEMLEESAPVMGVNDTAVNLRLFEARLTRD
Length1666
PositionKinase
OrganismParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Paracoccidioides.
Aromaticity0.07
Grand average of hydropathy-0.211
Instability index53.68
Isoelectric point7.10
Molecular weight184869.68
Publications
PubMed=22046142

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25703
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.84|      16|      17|    1523|    1538|       1
---------------------------------------------------------------------------
   21-   34 (23.43/ 7.11)	G..SSAPQL.VPLAPAP
 1523- 1538 (25.12/ 8.18)	GAASSIPAA.ATATAAP
 1540- 1556 (23.29/ 7.02)	GPSTSTPAAvKGAEPAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.47|      26|      35|     135|     164|       2
---------------------------------------------------------------------------
  135-  164 (43.25/29.70)	PneqsLRP..PWSF....RSGMSSSAAR....RASESSQW
  171-  202 (40.53/19.33)	P....LLPirPWQYspqeRSPYHTPTAS....DAQKDDTW
  208-  233 (28.69/10.24)	......TT..P..Y....RMSNPAKAPRfldnKSADFSPW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.57|      17|      18|     900|     917|       3
---------------------------------------------------------------------------
  900-  916 (27.28/13.63)	LITSLLEVGVRIPTEAP
  921-  937 (26.29/13.78)	LRRDQMEREKQLSMEAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.32|      32|      35|     736|     767|       4
---------------------------------------------------------------------------
  736-  767 (52.76/32.58)	FQVDLE.SETIEVVKQSIRRRLPTMF.PEVRTDV
  771-  804 (46.56/27.87)	MTDDLDfSAVTWTVKCEIGQWLRDVVaSHVRDSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     137.45|      30|      35|    1593|    1622|       5
---------------------------------------------------------------------------
 1564- 1591 (33.83/17.95)	.LPTPPNSNYNAPSVAPSHmTPTTSISSF..
 1593- 1622 (56.90/36.46)	PLPNPPSSVYNATSHIPCN.DPNSFVGDLRL
 1631- 1658 (46.71/28.29)	PFPLRPWEMLEESA..PVM.GVNDTAVNLRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.84|      21|      21|    1053|    1073|       6
---------------------------------------------------------------------------
 1033- 1070 (26.24/14.62)	PDLssllppligvgcvalqsF.YVLIKYLLRTGDLREGI
 1071- 1094 (26.60/14.92)	PDL...............teFrQSLIQLLDKRLANAGGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.57|      12|      15|      90|     101|       7
---------------------------------------------------------------------------
   90-  101 (22.40/13.71)	PLVPRDNNQYLA
  107-  118 (22.17/13.48)	PLDPQHNTPSTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      27.95|      10|      23|    1413|    1429|       8
---------------------------------------------------------------------------
 1413- 1426 (11.01/11.10)	LISIScialSQTIS
 1439- 1448 (16.94/ 6.56)	LINIS....SQAAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     316.97|      92|     263|     286|     381|       9
---------------------------------------------------------------------------
   14-   69 (24.14/ 7.08)	...........SRVSAPSgssapqlvplapapapaPAPPPPARAIDPDVQVISVID...............LTAES.DTDRVS...............................................
  286-  377 (157.94/112.29)	FAASLEQRQNHNRVTAPS.................TFRPPPRVTLTDNKRETWLRD...............LANDSVPLRRLSRTIP...HGVR..GKVLLEHCLVK.SVHISRALWVAKCVGANELRAF
  391-  459 (56.77/28.15)	.................................................EAKWVRDwtvnvqqfiegvlgsLVDDSWKIR.....IC...YALRltGRLFLEY.LVD.HDHFME..WFHTSSSKASLASF
  507-  551 (31.72/12.66)	..............................................................................IRRLSRIIKkivHHCP..SSFILPRCWAKyETTLSSCLDMNSTEDKK.....
  553-  594 (46.40/23.46)	FAALQERNASISRV.....................KVEPGPK....DNSPLQHIIE...............LLDSSSDIPTL................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.79|      14|      16|    1470|    1483|      10
---------------------------------------------------------------------------
 1470- 1483 (30.02/15.06)	RHQC.AR..FFRDRCPP
 1486- 1502 (19.77/ 7.48)	HPQNqPRllFLFGPIPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.39|      19|      23|     945|     967|      11
---------------------------------------------------------------------------
  945-  967 (22.74/28.16)	ADIntaTPSRTFrHALDQLLASG
  971-  989 (32.65/21.98)	DEV...TMTRIF.NTLSKRLEYG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.91|      36|     102|    1264|    1306|      13
---------------------------------------------------------------------------
 1264- 1306 (44.73/44.19)	DAAMEIRQRAeqqLLAITFTpLIApppALSSPIEPDAIATSDV
 1371- 1406 (63.18/35.76)	QAAQEISIRF...WLYIMLR.LIA...IHRSDLDPSSLSKSDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.94|      22|      67|    1113|    1134|      15
---------------------------------------------------------------------------
 1113- 1134 (38.21/22.51)	FPSQALSLLQDLLAG.VSQATAE
 1181- 1203 (33.73/19.00)	FTSQALSLLLTIPDGsVLDAAKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.90|      14|      17|     666|     682|      16
---------------------------------------------------------------------------
  666-  682 (20.31/27.85)	LY..HIICELVRSqtfSVS
  683-  698 (20.59/14.94)	KYlqWLIARGVLS...SVS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25703 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AASFIPPKQPKQSSPASGAASSIPAAATATAAPAGPSTSTPAAVKGAEPAPTPESSQTLPTPPNSNYNAPSVAPSHMTPTTSISSFQPLPNPPSSVYNATSHIPC
2) DPNSFVGDLRLQQQGQDVGPFPLRPWEMLEESAPVMGVND
3) IRPWQYSPQERSPYHTPTASDAQKDDTWCLEVQTTP
4) MPLRRPTSHPVSPSRVSAPSGSSAPQLVPLAPAPAPAPAPPPPARAIDPDVQVISVIDLTAESDTDRVSDDGSGPPAKRPCLDTRESSTPLVPRDNNQYLAIHQQPPLDPQHNTPSTASEVPESINPMDLMNHTPNEQSLRPPWSFRSGMSSSAARRASESSQWSQSA
1506
1612
175
1
1610
1651
210
168










Molecular Recognition Features






MoRF SequenceStartStop




1) IDPDVQVISVID
47
58