<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25701

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDAMKTVRNPWLQWKKFLHQCLSQRTDASEFRGFAKLMLNRYPMPGKKLVDAILESRSVTNVPWDPLIPLYVDSLHRIERVKIEEILKSLLSHSTVSQKQESVQSISRPKTSVSTLMSDYCIIHNATIAATSGHAPNTTTDAANIFAALAHWIITLLSWMSSNEAGREPADLLANSPDTLAVFESLGILLAALVGTEKSVNAFSSSESKGWRNKLSRALSAYIPLCSGVSIPLRDRLEVLRKDFNLYVHDGQKSLEDTMMENVNISALEFESNVLDGSIMNSRAGPYIYINALLFGRPLIDDSMFINYLNNRYGHDRMTLIEDLITATFDVLSNGMYRNEPNRTMFIFRSFLVNKLPPFFAEMCASSIDPIPMELCITRALSRIDPNAFPSFSEMFTMQGNSILSDVRQEFLFACALHKLIPEASIERLLGENPMQTLPVGGQLRREYLVSQINNNPERAEQLINELESMEGNAGAIAAAITEVMHSLCSRKDTMTLKNICNALSRRPQSLDVMLLFISSSTILQPLCSLLDAWKWDEEQGENQPVYDEFGGILLLVLAFKHKYGLSHQDLGISNPDSFVLRLLQHGSSSQRLEDLDEKQKNNLGAWITALFIAEGISDESMSSCSPQEFYTLVATLFSQSLAACEAGKLEFETLKGGFEFMALTWLGHHILESESDISASLKILLALVKPSSISGEGQEIHRTVLLITAKSLEDQLKGVRTRHPSRNDLKTILEALEPYHSFQQRGTARCGEVEGWAANPAGGGIVASIRNAFSSLVLWSTDPDISMTPPSYTHRQLVAGIKLVGAVRVLRGIVDELRLQAETGSGDLALDIAATLICAPLSESFAAEQAEFHPLNSSKDAISRRPILTLRDALAFERDSISKMIDTDTLRAELIVRLNRRVDSLTAIPQITQEVSNIDVSNIMQDINLDEEQMGIGGQGQAHDTDQGGKQTGQPDQRGEDAGSLSQILDATVAVASRAGELGTGNGQGMGIGIDMGMDGGMDTSIDDVLNGADMGVDNPEFLDLDMEGMF
Length1032
PositionTail
OrganismParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Paracoccidioides.
Aromaticity0.06
Grand average of hydropathy-0.114
Instability index43.69
Isoelectric point4.96
Molecular weight113663.13
Publications
PubMed=22046142

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25701
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     463.72|     152|     393|      15|     180|       1
---------------------------------------------------------------------------
   15-  180 (228.52/178.25)	KKFLHQCLSQR..TDASEFRGFAKLMLNRYPMPGkKLVDAILESRsVTNVP..WDPLIPlYVDSLhriE......RVKIEEILKSLLSHSTVSQKQESVQSIS.RPKT........SVSTLMSDYCIIHNAtiaatsGHAPNTTTDAANIFAALAHwiITLLSWMSSNEAGREPADLLANSPDTL
  409-  579 (235.20/146.36)	QEFLFACALHKliPEASIERLLGENPMQTLPVGG.QLRREYLVSQ.INNNPerAEQLIN.ELESM...EgnagaiAAAITEVMHSLCSRKDTMTLKNICNALSrRPQSldvmllfiSSSTILQPLCSLLDA......WKWDEEQGENQPVYDEFGG..ILLLVLAFKHKYGLSHQDLGISNPDSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.70|      47|      55|     911|     964|       2
---------------------------------------------------------------------------
  911-  964 (74.26/72.66)	QITQevSNIDVSNIMQDINLDEEQ.MGIG.GQGQahdtdQGGKQTGQPD.QRGEDAG
  968- 1017 (70.44/49.81)	QILD..ATVAVASRAGELGTGNGQgMGIGiDMGM.....DGGMDTSIDDvLNGADMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.03|      14|      21|     620|     633|       3
---------------------------------------------------------------------------
  620-  633 (27.13/21.50)	ESMSSC..SPQEFYTL
  640-  655 (19.90/13.45)	QSLAACeaGKLEFETL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.72|      15|      22|     265|     279|       4
---------------------------------------------------------------------------
  265-  279 (24.86/13.12)	ISALEFESNVLDGSI
  290-  304 (26.86/14.72)	INALLFGRPLIDDSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.87|      16|      21|     860|     875|       7
---------------------------------------------------------------------------
  860-  875 (26.99/21.10)	KDAISRR.PILTLRDAL
  879-  895 (22.88/16.56)	RDSISKMiDTDTLRAEL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25701 with Med5 domain of Kingdom Fungi
Unable to open file!