Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDAQLLTPLSTLETRLNNLLMAIISSPTAAGAPAAALALLDADDSLSRALETLHTHQSNYAKILRLRAEALSLEERVRNIVREVETVGNEISAACQHGADGSDDDSDDDSGIEEEAEQYGEDLDTHMGGVSEPSSTSLNSRGRRSKEVDYKLLVEFARRISRYNSDAAADASAVRSTRTPPGDEEQQHKQRDRSNVENGDAAERAAVGLGPDAAQQTKGVGVAALSQETVSWLDETANWSRDLSRMQYPSEDRIRMGLMGQLQAAVSEGLDVEKEIERLIRMSRDEGEGGSDDGAASEHAAVRGEIAGIVGEPGSFAGGGIGRRDAAMGGRAPMKAKPKPVLDLELYDPAEDD |
Length | 353 |
Position | Middle |
Organism | Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Paracoccidioides. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.598 |
Instability index | 48.77 |
Isoelectric point | 4.58 |
Molecular weight | 37768.98 |
Publications | PubMed=22046142 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP25696 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 91.15| 29| 31| 265| 295| 1 --------------------------------------------------------------------------- 267- 295 (49.57/28.14) SEGLDVEKEIERLI.RMSRDEGEG.GSDDGA 297- 327 (41.58/17.65) SEHAAVRGEIAGIVgEPGSFAGGGiGRRDAA --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 63.55| 21| 31| 164| 189| 2 --------------------------------------------------------------------------- 164- 189 (25.40/28.07) NSDAAADAsAVrstRTPPgDEEQQHK 198- 218 (38.15/20.65) NGDAAERA.AV...GLGP.DAAQQTK --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 58.29| 19| 31| 34| 52| 3 --------------------------------------------------------------------------- 34- 52 (28.72/21.28) AAALALLDADDSLSRALET 68- 86 (29.56/22.13) AEALSLEERVRNIVREVET --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DYKLLVEFARRI 2) ERLIR 3) GGIGRRDAAMGGRAPMKAKPKPVLDLELYDPAEDD | 149 277 319 | 160 281 353 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab