<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25695

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLIMEDSIDVDDLFGGSNFPGARAGSHSAYHQRATPKTRRATAFGMLKIAWSKLGAIAYVSQDGQRVHLRYLYCRPDDGKWTLSDEAPINQITDPHGVHAIVHLLWNEAGSELAIVDSSGRISIVTILTTLNTINFARQASIDPDDDWAQPVGLMWLSVNRPLFGFHKATRTDDRWSYPAHRRRPLGPLHPVNKSGLVLVTKSGHIKIIYQNPDMRWAEISTELTSIGYSDGILTHAAMAPAEGSGISIATHSECREICFYRVQVRWDPPEWDQTLKQGGQPNPFPTPSFQILRTKTDTLSDVFHPPVHDTENLSDFSAANGAVYRVTHLEIITAPQVLPGAQSASGPCVLALASIPVHSQLGQPHPSVPSSVLIRWQLDTMAQTLHPSFDDVASNKTAANPKSKIAFRRQEDIYFDRFVVSIDHMEAGGVVVITYDDSSISFFDAKTMRPVNENEDVNVVTSMPNAGFTFPIDASGLHIAFSPSGCLAVVLDGEWQMHLRYMEHSYGMEDGMYNNDKFTCAIAALALGYVRACGSDTSADDILSVIVRQLNPDAQMSFVTEVYSILFMSVDFTEQDKLVNNQSIQKGLSMQAVLGFRSRFQPRALTSAVPWIILNIRQIMLLILTFSHYLKSGRESTPCEPEVLRMVLGNVKWILDLAKYLVDNLFEIADTIPTDRSSFSLSSKTYESLSLVLILSSVPRSFLRHIFRYLNRFPLTFKAANNLSGESYQIFASISDTIEQASLKPDVCEKMLAHIDSLVARSYQAAGFSNAERNAPERELLITCSIPPVLQPVIMSILTETMPLVVRPEVDRMALALYDYSWLGIGDDKRTELFKRTHDVDILKRNVGRLLDGSVAKRRCVRCCEISEDVSLPRSVGMYRWIGKIGVLRMCVCGGLFAMENVERLNQVPFPVYR
Length916
PositionTail
OrganismParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Paracoccidioides.
Aromaticity0.09
Grand average of hydropathy-0.083
Instability index47.44
Isoelectric point6.13
Molecular weight102122.66
Publications
PubMed=22046142

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25695
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     127.26|      24|      66|      77|     100|       1
---------------------------------------------------------------------------
   77-  100 (45.23/21.49)	PDDGKWT........LSDEAPIN....Q.....ITDP.HGVH
  145-  168 (28.00/11.02)	PDD.DWA............QPVGlmwlS.....VNRPlFGFH
  172-  208 (27.41/10.67)	RTDDRWSypahrrrpLGPLHPVN....KsglvlVTKS.GHIK
  214-  234 (26.62/10.19)	P.DMRWA.......eISTE..LT....S.....IGYS.DGI.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.09|      25|     430|      48|      73|       3
---------------------------------------------------------------------------
   48-   73 (42.52/33.21)	LKIAWSKLGAIAYVsQDGQ.RVHLRYL
  479-  504 (44.57/29.87)	LHIAFSPSGCLAVV.LDGEwQMHLRYM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     227.83|      79|     171|     563|     656|       4
---------------------------------------------------------------------------
  563-  656 (117.99/111.04)	EVYSIlFMSV.DFTEQdKLVNNQSIQKGL.........SMQAVlGFRS..RFQP.RAL..TSAVPWIilnIRQIMLLILTfshylksgrESTP..CEPEVLRMVLG..NVKWI
  728-  825 (109.84/68.18)	ESYQI.FASIsDTIEQ.ASLKPDVCEKMLahidslvarSYQAA.GFSNaeRNAPeRELliTCSIPPV...LQPVIMSILT.........ETMPlvVRPEVDRMALAlyDYSWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.06|      11|      80|     279|     290|       7
---------------------------------------------------------------------------
  279-  290 (20.42/13.79)	QGGQPNPfPTPS
  362-  372 (23.64/11.12)	QLGQPHP.SVPS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25695 with Med16 domain of Kingdom Fungi
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