<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25692
Description |
Mediator of RNA polymerase II transcription subunit 7 |
Sequence | MAETGQQKVTAAFPPPPPFWKHFTTQNLKKLEECKKQHEENIGSKQTWTPETLRLLELPAELRFMVPPKAPISGSYSLFGEWQSVSINLPSLQDQGIEQLYPQPPSGDENALPPNHRFYLLKISKSLLLNFLEFVGVLALCPGHFESKVQDIRNLFINAHHLLNLYRPHQARESLIMMMEEQLEKTKEEIREMDRVKEKVHGFLEKLEAEGSNAAAQLTGTGTRSGPSNVAKAHQTTNGEEEVIEEARSVWNLLDEIDED |
Length | 260 |
Position | Middle |
Organism | Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Paracoccidioides.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.570 |
Instability index | 49.96 |
Isoelectric point | 5.37 |
Molecular weight | 29548.18 |
Publications | PubMed=22046142
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery.
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364060
ECO:0000256 ARBA:ARBA00003669
|
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi
|
Interaction
Repeat regions
Repeats |
>MDP25692
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 82.54| 25| 51| 58| 85| 1
---------------------------------------------------------------------------
58- 85 (41.79/29.68) LPAELRFMVppkAPISGSYSL.FGEWQSV
112- 137 (40.76/21.12) LPPNHRFYL...LKISKSLLLnFLEFVGV
---------------------------------------------------------------------------
|