<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25685

Description Uncharacterized protein
SequenceMPSRRPTSHPVSPSRVSAPSGSPAPLAPAPAPAPPPPALAIDPDVQVISVIDLTAESDTDRVSDDGSGPPAKRPCLDTRESSTPLVPLDNKNQYLAIHQQPLDPQHNTPSTASEVPESINPMDLMNHTPNEQSLRPPWSFRSGMSSSAARRASESSQWSPSTGLPLLPIRPWQYSPQERSPHDTPTAADAPKDDTWCLEVQTTPYRMFKPTKAPRFPDNKLADFSPWTGSQVEDVLSEHTIKHGFYDRVQVSPNESVSARSTLYPQFKHRSGLKVLSSVFAASLEQRQNHNRVTAPSTFRPPPRVTLTDNKRETWLRDLANDSVPLRRLSRTIPHGVRGKVLLEHCLVKSVHISRALWVAKCVGANELRAFRRKGTSATVASGLEAKWVRDWTVNVQQFIEGVLGSLVDEGWKIRLCYALRLTGRLFLEYLVDHDHFMEWFHTSSSKASLASFPVWLLMLGSYWDHVVKYRKRGKRLAECLLEKLSTAILINKNGHLNSLIRRLSRFIKKIVRHCPSSFILPRCWAKYETTLSSCLDMNSAEDKKDFASLQERNASISRAKVEPAPKGNSPLQHIIELLDSSSDIPTLATDLLNLSLDPSTVATTVLEWASTAFRYGTSRTYTAVRLFRRWRRIGMDTDLYLFTFLAQAHQKSGVRLVDLYHIICELVRSQTFSVSKYLQWLIARGALSRVSENKERMPGDVGLLSNLPSCRLPGHVWNLRNTLLSRTGFQVDLESETIEVVKQSIQRRLPTMFPEVRTDADVQMTDDLDLSAGTWTVKCEIGQWLRDVVAYHVRDGMRTAWDFTNDFGIVSLTPQEFFEVRYVLESLDDMSMFADVLKCASESDNVTVLISAVDALNYHLDTFNAIGATPDLFKSLVISYARIRTADSRIDHLITSLLEVGVRIPTEAPSVAMLRRDQMEREKQLSMEAPSPVSDDIADINTATPSRTFRLALDQLLASGNTMDEVTMTRIFTTLSKRLEYGSVNGKQCTHETARYFVRLRPFNTKLFDRLMIRWVITVLKSSPRPNLSSLLPPLIGVGCVALQSLYVLIKYLLRTGDLREGIPDLTEFRQSLIQLLDKRLANASGAQDLVAYRFKMAQQEYVRLFPSQALSLLQDLLAGVSQAIAESPKRAGGDPLGDSVKPLLSEIAVRHPHVLGMDGSDRLLEKFPDCMKFTSQALSMLLTIPDGSVLDAAKETIASINDFSRPFCLMKLRLLFVESDVESKKRIYDLVYEAAKSDIQQGLSDWIHVVSTLHADAAMEIRQRAEEQLLAITFTSLIAPRPALSSPTEPDAIATSDVSPLVYLRIVEELSFSILDAGNLSLGPVFVDKMNIMLQKITALENSILNTDSSQDTAQINNLREAQATQEISIRFWLYIMLRLIAIHRSDLDPSKLSKSDIVDQTRLLISISCIALSQTISSTNVPSVPLSHSLTNISSQATNNLQTQALDVAATLVDTIPDEARHQCACFFRDRCPPYIHPQNQPRLLFLFGPIPPTDIAASFIPPKQPTQSSPASGAASSIPAAAAGSSPTSTPAAAKGAEPAPTPESSQTLPTPPNSNYNAPSVAPSHMTPTTSISSFQPLPTPPSSVYNATLHIPCNDPNSFVGDLRLQQQGQDVGPYPLRPWEMLEESAPVMGVNDTAVNLGLFEARVTRD
Length1655
PositionKinase
OrganismParacoccidioides brasiliensis (strain Pb18)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Paracoccidioides.
Aromaticity0.07
Grand average of hydropathy-0.222
Instability index51.33
Isoelectric point6.86
Molecular weight183716.46
Publications
PubMed=22046142

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25685
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.25|      18|      18|    1518|    1535|       1
---------------------------------------------------------------------------
 1500- 1514 (22.69/ 6.82)	AASFI.P.P...KQPT.qSSP
 1518- 1535 (31.60/12.49)	AASSI.PAAAAGSSPT..STP
 1537- 1557 (23.97/ 7.64)	AAKGAePAPTPESSQTlpTPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     101.83|      18|      19|      99|     116|       2
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   84-   98 (17.95/ 7.15)	....PLVPLDNKNQYLA.IH
   99-  116 (33.78/21.63)	Q..QPLDPQHNTPSTASEVP
  117-  136 (26.10/14.61)	EsiNPMDLMNHTPNEQSLRP
  179-  191 (24.00/12.68)	R..SP....HDTP.TAADAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.10|      17|     119|     940|     958|       3
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  905-  921 (30.67/ 9.84)	IPTEAPSVAM.LRRDQME
  941-  958 (24.43/13.72)	INTATPSRTFrLALDQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.17|      22|      23|     240|     261|       4
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  232-  253 (35.28/22.04)	VEDVLSEHTIKHGFYDRVQVSP
  254-  275 (34.15/21.07)	NESVSARSTLYPQFKHRSGLKV
  276-  293 (20.74/ 9.65)	LSSVFAASLEQRQNHNRV....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.48|      15|      18|     484|     501|       6
---------------------------------------------------------------------------
  472-  489 (15.86/12.45)	KRGKrlAECLLeKLSTAI
  493-  508 (21.62/ 8.01)	KNGH..LNSLIrRLSRFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.64|      20|      25|    1066|    1090|       7
---------------------------------------------------------------------------
 1069- 1088 (33.00/34.95)	EFRQSLIQ.............LLDKRLANASGA
 1093- 1125 (24.64/ 6.32)	AYRFKMAQqeyvrlfpsqalsLLQDLLAGVSQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.94|      25|      36|     733|     768|       8
---------------------------------------------------------------------------
  733-  758 (38.41/44.51)	DLESETiEVVKQSIQRRLPTMFP.EVR
  770-  795 (41.52/19.95)	DLSAGT.WTVKCEIGQWLRDVVAyHVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.35|      15|      15|    1582|    1596|       9
---------------------------------------------------------------------------
 1582- 1596 (28.47/13.79)	PLPTPPSSVYNATLH
 1598- 1612 (28.89/14.09)	PCNDPNSFVGDLRLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.31|      12|      21|    1002|    1013|      10
---------------------------------------------------------------------------
 1002- 1013 (22.17/ 9.43)	RPFNTKLFDRLM
 1026- 1037 (21.13/ 8.69)	RPNLSSLLPPLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     221.04|      61|     263|     538|     620|      11
---------------------------------------------------------------------------
  538-  598 (100.63/49.85)	MNSAED.KKD.FA..SLQERNASISRAKVEPAPKGNSPLQHII.ELLDSSSDIPTL..ATDLLNLSLD
  798-  862 (85.49/39.94)	MRTAWDfTND.FGivSLTPQEFFEVRYVLE.SLDDMSMFADVL.KCASESDNVTVLisAVDALNYHLD
  864-  900 (34.92/ 6.85)	FNAIGA.TPDlFK..SL.....VISYARIRTA...DSRIDHLItSLLE....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.19|      30|     259|    1126|    1210|      12
---------------------------------------------------------------------------
 1177- 1210 (45.87/100.97)	SQALSMLLTipdgSVLDAAKETIASINDFSRPFC
 1438- 1467 (52.32/11.37)	SQATNNLQT....QALDVAATLVDTIPDEARHQC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.81|      46|     263|      29|      76|      15
---------------------------------------------------------------------------
   29-   76 (77.38/49.86)	APAPAPPPPALAIDPDVQVISVIDLTAES.DTDRVSDdgSGPPAKRP......CL
  295-  347 (73.43/41.10)	APSTFRPPPRVTLTDNKRETWLRDLANDSvPLRRLSR..TIPHGVRGkvllehCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.95|      10|      27|     399|     412|      19
---------------------------------------------------------------------------
  406-  429 (10.38/ 9.31)	SLVDEGWkirlcyalrltgrlFLE
  430-  439 (20.57/ 6.52)	YLVDHDH..............FME
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25685 with Med12 domain of Kingdom Fungi
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