<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25681

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGIIMDAVNASGPGRETTRHDVLQGAVSNTSLPSQNNGNYSNGPSHTKDATKPTANPSLDDSLPLELVHISQGFFPLGQLINRAAQQCWNDLTDLIAELADPQTTTLNSSSHAASASTSASASASASAAAATATANGKYPSSQSADSAQKKLRILEFAQSKRADFIKILVLSQWSRRAADVSRLIDIQAFIRMRYDCYNGAILSIGEMKRDLIRAQTANPDLAMALEVLSTGKVAAMNECSFIPPKPLTPKMMLKTLRRINKAIRTRLVLHDQVPAAFTNYVVHDGRVTFKVPTEFEVDLSIAQEDRSSQFFFVDIRFLFSPSPPKPTGRLLDELDNRVNAMLMHSGLTGCFNLLHNLVLSNKITILFHQAIELARGPWLDTLRVEVLHRTLVVQYWINRPRPKSWIEIGIKSGRRKIQIQDCSTPASPLLGLRWMRDGKEVQSKCIKFDLELLSIEAILRSVIALHISYLLQSTYAGLSQGRLYASGALSVSLQTSMTEPGDCFLDVQLTKGRDLRVMIEPVSGTIIFRSTPLLLNRHDMDRSSEKPVVDDIVFRISRLRSAAAVDEVESLSSAFGWQTVNSRDIRGEDLRRIFPANTLRSILFFRKSWERNWGVAYTCSMDGDHWWVVELRAPSTQKGPFSPQSARMVTGRYGGSPHRLNYGSFGQLDHALSGVLAIHANARCLSELHGIHHFPSLSNLVLGPHLHVPNIFIRFRTVSLPPALQISPPIANNGKPPIKDTIRLSFRGIDPSSQCAIMIAYGHFSREIKDISLLAVRLDRSIAFQPKGRAFAMRFLTPVGQPVIIQLLARLQQLERIISTLEILKRKSLKPLSLTLTRVRFAYAAEENARASINFNYHEQAILSDIDSITRLPKQTPLMILRTTMDFHPQSPHRRIKESLTAILNGTLRPRTFTCVDTVLQLLIITLPVLKALDHISIDPHTDLPGNSRLQIISRSSKIFHLRYPSVRYRFCIYAALRRDRLVWVLRDVANPAEKDAQEPLEGKLRETIYSARRDGWQGMGNGALADSESVGALLSALHGVMTDYLSSMTGIPVGEGGPSGGGTRPDGEKPVHNNFAGKDTDSKSKPQSGQAGMTGLQGHPGSMGWTKGLAAAATQTTDNSDIGMGGHAPSDLGAMKQKLTSAQNKDNRNIAARPTVNGNNKGISNGNGVAFITID
Length1178
PositionTail
OrganismParacoccidioides brasiliensis (strain Pb18)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Paracoccidioides.
Aromaticity0.06
Grand average of hydropathy-0.197
Instability index44.95
Isoelectric point9.65
Molecular weight129762.27
Publications
PubMed=22046142

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25681
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.38|      17|      78|     245|     262|       1
---------------------------------------------------------------------------
  245-  262 (28.64/18.62)	PPKPlTPKMMLKTLRRIN
  325-  341 (31.75/16.57)	PPKP.TGRLLDELDNRVN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     515.99|     161|     363|     525|     693|       2
---------------------------------------------------------------------------
  525-  693 (270.32/196.59)	SGTIIFRSTPLLLNRHDMDRSSEKP......VVDDIVFRISRLRSAAAVDEVESLsSAFGWQTVNSRDIRGEDLRRIFPANTlRSILFFRKS...WERNWGVAYT.C...SMDGDHW.WVVELRAPSTQKGPFSP.........QSARMvTGRYG.GSPHRLNYGSFGQLDHALSGVLAIHanarcLSELHGI
  870- 1054 (245.68/157.18)	SITRLPKQTPLMILRTTMDFHPQSPhrrikeSLTAILNGTLRPRTFTCVDTVLQL.LIITLPVLKALDHISIDPHTDLPGNS.RLQIISRSSkifHLRYPSVRYRfCiyaALRRDRLvWVLRDVANPAEKDAQEPlegklretiYSARR.DGWQGmGNGALADSESVGALLSALHGVMTDY.....LSSMTGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.66|      15|     363|      11|      25|       3
---------------------------------------------------------------------------
   11-   25 (27.96/15.68)	ASGPGRETTRHDVLQ
  376-  390 (28.70/16.29)	ARGPWLDTLRVEVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.51|      13|      78|     715|     728|       4
---------------------------------------------------------------------------
  715-  727 (22.74/16.17)	IRFRTVSLPPALQ
  744-  756 (21.78/ 9.02)	IRLSFRGIDPSSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.69|      26|     928|     175|     244|       7
---------------------------------------------------------------------------
  131-  167 (27.58/72.34)	AATATangkyPssqsaDSAQkKLRIL...EFAQSKRADFI
  216-  244 (40.11/16.49)	AQTAN.....P.....DLAM.ALEVLstgKVAAMNECSFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.93|      24|      27|    1098|    1124|       8
---------------------------------------------------------------------------
 1098- 1122 (41.46/35.65)	GLQGH.PGSMGWTKGLAAAAtQTTDN
 1126- 1150 (40.48/22.36)	GMGGHaPSDLGAMKQKLTSA.QNKDN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25681 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GIIMDAVNASGPGRETTRHDVLQGAVSNTSLPSQNNGNYSNGPSHTKDATKPTANPSLDDSL
2) MTGIPVGEGGPSGGGTRPDGEKPVHNNFAGKDTDSKSKPQSGQAGMTGLQGHPGSMGWTKGLAAAATQTTDNSDIGMGGHAPSDLGAMKQKLTSAQNKDNRNIAARPTVNGNNKGISNGNGV
3
1051
64
1172










Molecular Recognition Features






MoRF SequenceStartStop




NANANA