<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25680

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPAGALTNFRSIDGFCNIFWRIYSRVAAGPPTSQLNLRENPVLRSSNELRNSIILLRNLRCLVSPLANGSDLWIFSANPNFDALGPVYSNKGAGNDIIVAGSVTFQNSVSGSNSAAEIKHRLLSDPESSIFNEALQDKSMPISGELSKFQAYATYSAFFEAFISATSRALTLHFTQQQKVIPLGTRTLYSSLDENGYPRSSTHAPCTRNFTSFLSTLDINMTAKGKLIVSLSTLPQPGIEQLHLDSESDITAYLNNDLWLAPSGILCRLISIDGYQSNHSNIVSPENIGALPNDFERSIGKLDAMKQEWKRTVIEWLRKLGLNLKDPQTVLWVEVEVNVSDRPLYDTFSRFTGNRRKVSPFIQILWPSNLCFTRSRSNKTAPINPTEFFSSQAESPLQFAERWLNESFPEVQLLDEQKTDNPSEVDEKHLNYAELSPLDVDSSGIPESLARTVNIPDAQLASAVYPTPPGGALTHNLEAGMVVEGLGASTIEALNYPPSQGESIYNEHGGSTTYLHRNPDFLPAGLDATSSELGVGSGLYDTAADEEFFGDIDGTNFDTKGITEADFNFFDEPDFAGLTGNLEMQTETPEILQANESTSAVPHTYMTKAGAGPSHSVQNRLSAIDDSDSRIRNPSISSPNTTTSESQRSQATELGQAAPMDGSSRRPISPPLSPIQIKEILSSNGFAHSELGLVNSKTHKSHPEQNQYKPVIFQLKLGSSDKKYKLDGRFWFGPGRGHTTFKMGGYPSDIPTIGFPDKERENNPKLSITITSPSPLVSDNALETKVQSPSASSSCSSDNGSITDHGSKASLRPNNPVSLKRKRDSEGEGNTSLSPLERRTLAPGTAKVQLNDQQLALLGILLSEAVDWPLTGYFSRKENVVFPAFSRREDLPQAAQLVVDQVTQSSLCHIRDDLYKLEGTDWDCVLSDSLFDNSDAIGHMSKLDLRTFATIEDGPNTRKDAPSIKSNISGSICKICPPHVKIHRGNGFLEVLPAAIGFWETFGLEPLQGKKNVLPFCIYPPNITEAADSFMERLGLIYSSGNFGTHSRPSQSNGLIPWTLNAASDQDYASLMHALNISCENLGSALSNLSASDENVVIYIINPFVYEAAIVDICSAFIRLFHKYVGDVDRQHTRHLNELVLQIIPLEFIASPDTLIVPPQIDYLRLALEVYSRCPPKDRSSDWMGCAPPLVLADPIPKVVPFRLSSEPVAPLEEGKCLHVAYSQSVDQRWVTAAWTDSSGRYQTTLSYCLRERDSPVSRSISEIRTQIWETSKDIMDISSSYWRLMVVKDEPIGADEVDMWKSLLDQYNRDKSVKVELGILCVNIKPGLSLKLPTPPLQLSALSQQPTQTVPATTTPGSTPRPVPSPDPSGAAGTPPATHTTANTPMFTDSTHSHQQQQQLTQQVSQASLDSDQDTILIDKSDETWGVTLSHRLNNSYSLTKYQPALASGYLFRRSGTSDTDGLAVMSVNLIYTNSRRPTDHLLKDILRMYRELATLARTRGIIHVRGNYSLPWHIMTAIKGQEVLCYTL
Length1532
PositionKinase
OrganismParacoccidioides brasiliensis (strain Pb18)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Paracoccidioides.
Aromaticity0.08
Grand average of hydropathy-0.350
Instability index49.80
Isoelectric point5.38
Molecular weight168600.26
Publications
PubMed=22046142

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25680
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.62|      38|      51|     832|     870|       1
---------------------------------------------------------------------------
  832-  870 (59.89/43.06)	NTSLSPLERRTLAPGTAKVqLNDQ..QLALLGI...LLS.EAVDW
  881-  924 (54.73/34.29)	NVVFPAFSRREDLPQAAQL.VVDQvtQSSLCHIrddLYKlEGTDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.17|      27|      53|      29|      55|       3
---------------------------------------------------------------------------
   29-   55 (45.16/27.25)	AAGPPTSQLNLRENPVLRSSNELRNSI
   85-  111 (45.01/27.13)	ALGPVYSNKGAGNDIIVAGSVTFQNSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.34|      48|      53|     480|     529|       4
---------------------------------------------------------------------------
  471-  524 (70.69/54.43)	PGGALthnlEAGmVVEGLGASTIEALNYPPSQGESiYNEHGGSTTYLH..RNPDF..L
  525-  580 (68.65/43.36)	PAGLDatssELG.VGSGLYDTAADEEFFGDIDGTN.FDTKGITEADFNffDEPDFagL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.97|      32|      54|     587|     618|       5
---------------------------------------------------------------------------
  587-  618 (56.19/39.88)	QTETPEIL..QANESTSAVPHTYMTKAGAGPSHS
  642-  675 (50.77/35.13)	NTTTSESQrsQATELGQAAPMDGSSRRPISPPLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.86|      44|     865|     143|     231|       6
---------------------------------------------------------------------------
  178-  231 (56.37/113.89)	QQQKVIPLgtrTLYSSLDENgYPrSSTHA...PCtRNFTSFLStldiNMTAKGKLIV
 1053- 1099 (73.49/32.99)	QSNGLIPW...TLNAASDQD.YA.SLMHAlniSC.ENLGSALS....NLSASDENVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     402.93|     134|    1002|     284|     433|       7
---------------------------------------------------------------------------
  284-  433 (191.28/123.18)	IVSPENIGALPNDFERSIgkLDAMKQEwKRTVIEwLR......KLGLNLKDPQTVLWVEVevnVSDRPLYDTFSRFT.GNRRKVSPFIQilwPSNLCFTRSRSNKTApiNpTEFF.....SSQAESPL..QFAERWLnESFPEVQLLDeqKTDNPSEVDEKH.LN
 1289- 1437 (211.65/95.58)	VVKDEPIGADEVDMWKSL..LDQYNRD.KSVKVE.LGilcvniKPGLSLKLPTPPLQLSA...LSQQPTQTVPATTTpGSTPRPVPSPD...PSGAAGTPPATHTTA..N.TPMFtdsthSHQQQQQLtqQVSQASL.DSDQDTILID..KSDETWGVTLSHrLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.77|      40|     470|     238|     280|       8
---------------------------------------------------------------------------
  238-  280 (61.81/53.11)	QPGIEQLHLDSeSDiTAY.LNNDLWLAPsGILCRLISIDGYQSN
  711-  751 (73.97/48.56)	KPVIFQLKLGS.SD.KKYkLDGRFWFGP.GRGHTTFKMGGYPSD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25680 with Med13 domain of Kingdom Fungi
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