<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25673

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLIMEDSIDVDDLFGDPTSLELGLEATAPTIKGLPQRLDELRLSGCCQKVAWSKLGAIAYVSQDGQRVHLRYLYCRPDDGKWTLSDEAPINQITDPHGIHTIAHLLWNEAGSELAIVDSSGRISIVTILTTLNTINFARQASIDPDDDWAQPVGLMWLSVNRPLFGFHKATRTDDRWSYPAHRRRPLGPLHPVNKSGLVLVTKSGHIKIIYQNPDMRWAEISAELTSIGYSDGILTHAAMAPAEGSGISIATHSECREICFYRVQVKWDPPEWDQTLKQGGQPNPFPTPSFQILRTKTDTLSDVFHPPVHDMENLSDFSAANGAVYRVTHLEIITAPQVLPGAQSASGPCVLALASIPVHGQLGQPHPSVPSSVLIRWQLDTMAQTLHPSFDDVASNKIAANPKSKIAFRRQEDIYFDRFVVSIDHMEAGGVVIITYDDSSISFFDAKTMRPVNENEDVNVVTSMPNAGFTFPIDASGLHIAFSPSGCLAVVLDGEWQMHLRYMEHSYGMEDGMYNNDKFTCAIAALALGYVRACGSDTSADDILSVIIRQLNPDAQMSFVTEVYSILFMSVDFTEQDKLVNNQSIQKGLSMQAVLGFRSRFQPRALTSAVPWIILNIRQIMLLILTFSHYLKSGRESTPCEPEVLRMVLGNVKWILDLAKYLVDNLFEIADTIPTDRSSFSLSSKTYESLSLVLILSSVPRSFLRHIFRYLNRFPLTFKAANNLSGESYQIFASISDAIEQASLKPDVCEKMLAHIDSLVARSYQAAGFSNAERNAPERELLITCSIPSVLQPVIMSILTETMPLVVRPEVDRMALALYDYSWLGIGDDKRTELFKRTHDVDILKRNVGRLLDASVAKRRCVRCCEISEDVSLPRSVGMYRWIGKIGVLRMCVCGGLFAMENVERLNQVPFPVYR
Length917
PositionTail
OrganismParacoccidioides brasiliensis (strain Pb18)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Paracoccidioides.
Aromaticity0.08
Grand average of hydropathy-0.051
Instability index45.89
Isoelectric point5.71
Molecular weight102203.97
Publications
PubMed=22046142

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25673
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     226.59|      79|     171|     564|     657|       2
---------------------------------------------------------------------------
  564-  657 (117.95/129.98)	EVYSIlFMSV.DFTEQdKLVNNQSIQKGL.........SMQAVlGFRS..RFQP.RAL..TSAVPWIilnIRQIMLLILTfshylksgrESTP..CEPEVLRMVLG..NVKWI
  729-  826 (108.64/79.02)	ESYQI.FASIsDAIEQ.ASLKPDVCEKMLahidslvarSYQAA.GFSNaeRNAPeRELliTCSIPSV...LQPVIMSILT.........ETMPlvVRPEVDRMALAlyDYSWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.58|      26|      64|     385|     410|       4
---------------------------------------------------------------------------
  385-  410 (42.71/30.09)	AQTLHPSFDDVASNKIAANPKSKIAF
  448-  473 (42.87/30.24)	AKTMRPVNENEDVNVVTSMPNAGFTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.08|      20|     170|     179|     200|       5
---------------------------------------------------------------------------
  179-  200 (34.31/25.76)	SYPAHRRrpLGPLHP.VNKSGLV
  357-  377 (34.77/19.08)	SIPVHGQ..LGQPHPsVPSSVLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.15|      10|     428|      65|      74|       9
---------------------------------------------------------------------------
   65-   74 (20.05/11.72)	DGQ.RVHLRYL
  495-  505 (17.09/ 8.99)	DGEwQMHLRYM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25673 with Med16 domain of Kingdom Fungi
Unable to open file!