<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25670

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMAESFTLPLRPLSQKPLDESDSLPIRIAQINAQRGSFRNVTEQSLQEEIEARRAAEETGQELDGVESQEAKPTDRLKHVFKSRAQIVDFAMQAHAEANYALDFVSLLLSKYTPRQAEISMSPYLKQSAPLGSLETDVVKVPEKTAAAQKEIDNLSRGWKLESFDAAASKLLQSATRLEEEVAAETKYWAGILDIKEKGWKVCRLPRERQTLGVQFGFLEATPSFRDRGLAALRQGDGGQLTLDRGLQTSKPRSLRVRVHQDNQIVGASKLIRLVLSPDDPIECRIRLARDALYEEELFHEINREARTLLQHGVESKQNLIQFQANESQQILIDMVGLEDGILDLDQQEHVEDALAETVAQSLRLLLSHAHRLKYRRRTRIPPPVTEKRRPDPEYSLLKPTVGYLQHKSALRWLKSFLDSTTKTLQLAGLKCKYDTAPLVSVQLPPISSGAGAAFESDNPPFVERLVDSFLSPLESIITGTFLSPASSFKIRVTTSTNANALGTEFEIATNITSAPRSNSKSSRTGLRSDLQQIILHLFTIDLVFLIPHLAGTSESFPSTLTQPINHSQPPKDSKDDFNPPTPLPESYLTSWEPIFPENGELAAFSPSKRRSKKLTIDLHPNRLDVQCHWLDGPDTDSDYALFDGAVDVTAKLKGPPKGLIAHSWRVDANDAGGFDLQGGEKMLQDVLRDMSRGEIKEEL
Length699
PositionHead
OrganismParacoccidioides brasiliensis (strain Pb18)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Paracoccidioides.
Aromaticity0.06
Grand average of hydropathy-0.449
Instability index53.95
Isoelectric point5.80
Molecular weight77953.26
Publications
PubMed=22046142

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25670
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.20|      13|     192|     269|     281|       2
---------------------------------------------------------------------------
  256-  272 (16.16/ 7.60)	VRVHQDNQIvgasKLIR
  273-  289 (16.03/ 7.49)	LVLSPDDPIecriRLAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.96|      32|      34|     115|     146|       3
---------------------------------------------------------------------------
  115-  146 (53.17/36.47)	QAEI.SMSPYLK.QS..APLGSLETDVVKVPEKTAA
  148-  183 (37.79/23.71)	QKEIdNLSRGWKlESfdAAASKLLQSATRLEEEVAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.54|      56|     117|     458|     519|       5
---------------------------------------------------------------------------
  458-  519 (82.98/64.64)	NPPfvERLVDSFLSPLESII..TGTF..LSPASSFKIRVTTSTNANALgtefEIATNITSAPRSNS
  578-  637 (95.56/58.11)	NPP..TPLPESYLTSWEPIFpeNGELaaFSPSKRRSKKLTIDLHPNRL....DVQCHWLDGPDTDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     175.16|      49|     252|      48|     109|       6
---------------------------------------------------------------------------
   48-   96 (78.94/36.28)	EI..EARRAAE...ETGQELDGVESQEAKPT.DRLKHVFKSRAQIVDFAMQAHAE
  300-  351 (61.59/25.62)	EInrEARTLLQhgvESKQNL..IQFQANESQ.QILIDMVGLEDGILDLDQQEHVE
  375-  406 (34.64/22.67)	RR..RTRIPPP...VTEKRRPDPEYSLLKPTvGYLQH..................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25670 with Med17 domain of Kingdom Fungi
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