Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDSQLLTPLSTLETRLNNLLMSMVSSPTAAGAPAAALSLLEADDAVSSALKTLHTHQSNYAKILRLRAEALALEQRVRDIVREVENVGNEISTACQQGVGASDDGSSDTDSEMETEGEDPDTQMGGVSASPRGFSGVRKGKGKATNEIDYKLLVNFARRISRYNSDAAADVAAGTPGKTMPPEGDTEGQQQRASAHENNGEDAGRVGTSGQRVAKGVGVAALSQETVSWLDETANWSRDLSRMAFPSEEQIRMGLMGQLQAKASEGVDVEKELERLIRASEGTGAGGVDEDNDAGGGHATAKDGMAIGREHISVSGHGHAGGSIGQADAVMGGVSAPKEKPKAVLDLDLYDPDEDD |
Length | 356 |
Position | Middle |
Organism | Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.525 |
Instability index | 34.28 |
Isoelectric point | 4.66 |
Molecular weight | 37201.42 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP25653 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 255.54| 74| 81| 148| 228| 1 --------------------------------------------------------------------------- 104- 149 (27.57/12.82) ...................................DGSSDT.DSEMETEGEDpdtqMGGVsasprGFSGVRKGKGKATNEID..... 155- 228 (127.46/61.21) NFARRISRYNSDAAADVAAGTPGKTMP..PEG.DTEGQQQR.ASAHENNGED....AGRV.....GTSGQRVAKGVGVAALSQETVS 235- 313 (100.51/46.14) NWSRDLSRMAFPSEEQIRMGLMGQLQAkaSEGvDVEKELERlIRASEGTG......AGGVdedndAGGGHATAKD.GM.AIGREHIS --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EIDYKLLVNFARRISRY 2) GGVSAPKEKPKAVLDLDLYDPDEDD 3) LERLIR | 147 332 273 | 163 356 278 |
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