<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25651
Description |
Mediator of RNA polymerase II transcription subunit 10 |
Sequence | MAPLTLSVIDNDLKDVIQHLFEIQSAVHGYLGSETQQELVRKIEKDEGKDALHTLHHRSTFENLRYINSSDNTRKSLTLSLSTLSEHSRPDPSASPSQTSLRINDPDPPLQSVQLPPEIIDYVDAARNPDIYTREFVELVQRGNQDLKGKVQAFASFRDILAREMASAMPECKGEVERVLRVTGGSASS |
Length | 189 |
Position | Middle |
Organism | Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.534 |
Instability index | 43.64 |
Isoelectric point | 5.36 |
Molecular weight | 21082.34 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364146
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP25651
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 47.57| 17| 22| 38| 55| 1
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38- 55 (23.07/20.09) ELVRKIE.KDEGKDALhTL
62- 79 (24.50/15.36) ENLRYINsSDNTRKSL.TL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 52.04| 14| 14| 90| 103| 2
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90- 103 (25.17/12.88) PDPSASPSQTSLRI
106- 119 (26.88/14.14) PDPPLQSVQLPPEI
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