<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25649

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPAGALTNFRVLDGFFHIFWRIYSRVAPKSRGSQFDPLESSGLRNSNEVRSALLALRNDGCYVSQLANRSELWIFSPNPNFEALVQDSGNGKSDEDLIVAGKATFLNVASGVNTAAEVKHRLLSDPDSSIFESAATQNKLTTNCSEYAQLKSLTTYSAFYEGFISAISKALTLHFTKQQKVIPLGTRTLYSSLEENGYQSGDDDLPFSRKSTSFLSILDINVTSKGRLAISLCTLPQPGLEQLLRDSESEIIGARLSDDVWIAPSGTLCRLTSTGEYQSTQSNTVSPGHIATTPHEVEPLASKTKADKREWKRCVAEWLRIFGLQLNDPEAELWVEVEVNALDRQLYILFSKSNWNHQKSSPFIRILWPLKLCFTRSRSKMTAPANPTGFFSGQAESPLHLAERWVKEPCPIRQPFDKHKTSDDPSELEKQQQKCSEPSPLKLDHPEMPESLARVINLPEAQLASAVYPTPPGGGLAQGMGAGIVSEGLGTSAIDTLNYPPTQSEQIYNETVGPAAYFRGTSELLPTGLDPTTSELGIGSGLYDTAADEDFFGDMDVANFDTKGITEADFNFFDEPEFTGLTGDLDMQTGEPEAVPHDTEANFTAPDSSDTAMSITEPSPSNNDQNHLTKSEHDTIKQPAFSSLITTGDEDHICKETTELSQIISTDDSQKKRPISPPLSPVQIKKILSPDVSTNLRLTPFKSDISRLRVAPNQYSPVIFQPRLCSSDQKYKIDGKFWFTPGKRYITSNLGGSPSGIPTIGFPEKGRKVRPKPLPILTSLHPLISDNTLEIELQSPSTSSSGSSEGNSDTDHESNASSSHVMNFHPKRNRDYEVEGNSTPSPLDILTQTSDLDKGPLSEHQFALLGAFLSEGVDWPLTGYFSRKQNDIFPVFLRREDLLQTAQLVVDQITQSSFCHIRDDLHKPEWADWDDILSRSLFDNIDGLGHLSKLDLRTYVTLEDGSNPRKDGPSIRSNLTGSICKICPPHIKVHRGNSYLEILPSAIGFWETFGLEPLQGEKDIIPFCIYPPNVIEAAEAFIERLGLVYSSGNFGSHSRPNKANGLVPWSLNAASDQNYASLMHALNVSCENLGSSLSNLSATDKNVVIYIINPFIYDAAIVDICSAFLRLFHKYVGDIDRQHTRHLSELVLQIIPLEFIASADSLVVPTQTDYLRLALEVYSRCPPKDRSSDWLGCSPPLVLADPVPKVVPFRLAAESVAPLEEAKSLHVAYSQSVDQRWVTAAWTDNSGRHQSALSYCLRERDSSVSRPISEIRTQIWETSKDIMDMSLSHWRLIVVKDEPVDLEEVEMWTSLLDQYNRTKAIKVELGIISVNTKPGLSLKLPSSPLQPSALSQQAAQNGPSTTPGSTPRPVPSPDPSGPAATPPTANAPTYTDQHTPPQHAQQSSPDSDQDTILIDKSDETWGVTLSHRLNNSYYLTKHQPALASGYLFRRSGVSDTDGQAIMAVNIIYTNSRRPIDHLLKDILRMYRELITLARVRGIVHAQGNSPLPWHIMTAIKGQEMLCYTL
Length1527
PositionKinase
OrganismAjellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
Aromaticity0.08
Grand average of hydropathy-0.387
Instability index50.17
Isoelectric point5.29
Molecular weight168729.43
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25649
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     105.72|      28|      28|     531|     558|       1
---------------------------------------------------------------------------
  471-  497 (31.61/16.21)	..PTPPGG....GLAQGMGAGIVSEGLgTSAID
  501-  525 (23.27/ 9.75)	YPPTQSEQiyneTVGPAAYFRGTSE........
  531-  558 (50.84/31.10)	LDPTTSEL....GIGSGLYDTAADEDF.FGDMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     437.45|     149|     174|    1150|    1323|       2
---------------------------------------------------------------------------
 1150- 1323 (222.90/172.72)	LQIIPLEfIASADSLVVPTQTdylrLALEVYSRCPPKDRSSDWLGCSP.PLVLADPV.P..............KVVPFRLAAESvAPLEEAKSLHVAYSqsvDQRW.VT.AAWTDNS...GRHQSALSYCLRERDSSVSrpiseirtqiwET.SKDIMDMSLshwrLIVVKDEPVD..LEEV.EMWTSLLdQYNRTKAI
 1327- 1500 (214.55/116.46)	LGIISVN.TKPGLSLKLPSSP....LQPSALSQQAAQNGPSTTPGSTPrPVPSPDPSgPaatpptanaptytdQHTPPQHAQQS.SPDSDQDTILIDKS...DETWgVTlSHRLNNSyylTKHQPALASGYLFRRSGVS...........DTdGQAIMAVNI....IYTNSRRPIDhlLKDIlRMYRELI.TLARVRGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.65|      39|     224|     376|     433|       3
---------------------------------------------------------------------------
  377-  433 (50.31/74.33)	TRSRSKMTapanptgffsgQAesplHLAErwvKEPCPIRQP.FDKHKTSDDPSELEKQ
  619-  658 (67.35/39.41)	EPSPSNND...........QN....HLTK...SEHDTIKQPaFSSLITTGDEDHICKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     416.87|     147|     537|     130|     302|       4
---------------------------------------------------------------------------
  130-  302 (194.11/208.41)	SSIFESAATQNK...............LTTNCSeyAQLKsLTtysafyeGFISAISKaLTLHFTKQQKVIpLGTRtLYSSleENGYQ........SGDDDLPfSRKSTSFLSILDINVTSKGRlAISLCTLP.QPGLEQLLRDSESEIigaRLSddvwiAPSgTLCRLTSTGEYQSTQSNTVSPGHIAT.TP.....HEVE......PL
  663-  845 (222.75/150.33)	SQIISTDDSQKKrpispplspvqikkiLSPDVS..TNLR.LT.......PFKSDISR.LRVAPNQYSPVI.FQPR.LCSS..DQKYKidgkfwftPGKRYIT.SNLGGSPSGIPTIGFPEKGR.KVRPKPLPiLTSLHPLISDNTLEI...ELQ.....SPS.TSSSGSSEGNSDTDHESNASSSHVMNfHPkrnrdYEVEgnstpsPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.22|      16|      16|     971|     986|       5
---------------------------------------------------------------------------
  954-  972 (21.13/10.05)	LRTYVTledGSNPRKDGPS
  973-  988 (30.28/17.82)	IRSNLT...GSICKICPPH
  989- 1002 (16.81/ 6.39)	IKVHRG...NSYLEILP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.22|      14|      16|    1044|    1059|       8
---------------------------------------------------------------------------
 1044- 1059 (22.30/19.28)	GLVYSSGNfgSHSRPN
 1063- 1076 (26.92/15.17)	GLVPWSLN..AASDQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.68|      20|      85|    1022|    1043|       9
---------------------------------------------------------------------------
 1022- 1043 (28.47/29.20)	IIPFcIYPPNVIEAAEAFIeRL
 1110- 1129 (37.22/24.92)	INPF.IYDAAIVDICSAFL.RL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25649 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IRQPFDKHKTSDDPSELEKQQQKCSEPSPLKLDHPEMPESLARV
2) KETTELSQIISTDDSQKKRPISPPLSPVQI
3) LSLKLPSSPLQPSALSQQAAQNGPSTTPGSTPRPVPSPDPSGPAATPPTANAPTYTDQHTPPQHAQQSSPDSDQDTILIDKS
4) PEFTGLTGDLDMQTGEPEAVPHDTEANFTAPDSSDTAMSITEPSPSNNDQNHLTKSEHDTIKQPAFS
5) TLEIELQSPSTSSSGSSEGNSDTDHESNASSSHVMNFHPKRNRDYEVEGNSTPSPLDILTQTS
414
657
1338
578
790
457
686
1419
644
852










Molecular Recognition Features






MoRF SequenceStartStop




NANANA