<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25647

Description Uncharacterized protein
SequenceMIPHPSSHRPPSRPSAPSRRSSAHLYPASDPYPAIDSRPHQNTVIDLTESDHSGAADGERPAKRPRLDAGNGPSQSLEDPLRNQHQQHHQSQNQSSSQHHGSSTASEAPESSMNPLDIMNASSTEQTARPPWSFRSDIRRTGPGAQTELAQWSQSASLPPLPIRPWKYGIQGRHVAGATNQKDNEECGEVTTTPYRIDVPSIAPRFADNKPADFTPWRGSHPEDVLSEQTIKQGFYDRSPAPPTESTSARTSVYPHFKRRSGLKLLSSVFAAALEKRQALCTITAASTFRPPPRVTLTDIKREAWLRDLANPSVPLRRLSRTIPHGIRGKLLLDQCLGKSIPICRAIWLAKCVGANELRAFKRKGTSAGVASGLETKWVRDWTISVQQFIEGVIASFGDASWKLRISYSIRLSARLFLEHLIDQDHFLDWFLTSLGNSSFESLPVWLLMVGVYWQNIVRYRKRAKRLAECLLEKLRLVSDAGQNAHLNPLAQRLSRLTKTLTLYHPSSFILPRTWAKYESVLLSCLDMNLPDDKAAFQNLKARNTRVCRLQNDRGKPIQSINQRLIQLLDSSSDVSTICSECLNISQDYSILVTKLIEWASTSFRYGMARTYTVVRVFRKWKKSGVDIDSHILSFLIQDHWKSGVRFFDVYHVICELVRSQSFSVAKYLQWLMARGVLSNVSDFQQMHVSADIGLLGHLPPHRLPSHIWNLRNTLLSRTGFSVALENDTIQLIKASVRRRLPHMFPMLSINGDAEMTDDVDLTSLSWTVRSEIGNWIRDQVASHVKNSLKSAIDRDFASEVKTSALTPQEFFEVRYILECLCDFSMLADVLKYASGSNNVTVVASAVDTLNYHLDSFNAIGATGDLFKSFTGAYARISKTELSVQDLIASLLDVAIKLPAELSTLSMLRRDQLQRDRKLAMAACSPVSDHIVDTLNTANPTFTEELDQLLTSGNSMDESTMARIFDTLRKKLEAGSINGEQSAHETARYFANLRPFNTKLFDNLMIKWVISVMRSSPRPKLSSILPPLIGVGCVTLHSFYVLARAFLHSDAYKNAIPDLAELRIDMIQLLDDKLSNGNGSQGLVAYRFKIARQGYMRQYSGEALGLIQDLLANLSENRADSPPKQFNNDLLSTIVTPLLCEIIVRHPSIVGIGLAAAERTIESINDFSLPLCLINLRLLFSFECDNDVKKRIYDVVFEAAKSNMHKGQSHWIDVVGTLHADAAKEIRQRAEEQLLSLVLSSDSLPASPVSKSGAPTSVTASALVCLRIVEDLSFSVPENGSPSLGPMLIEKMNMILHRITILESHIMNTNITQYNDQAAAIRQAHATQESAITFWFYILLRLVSIHRSTFTPGTLSKSDLADQSRLLISITCIALSKTLSPKVPSARPYYIPPTTPLTFAVPPQGSRPQPLFYSTDAGISTNLRTQALDVAATLLDTIPDDSRHQCSRFFRDRCPPFLHPQNNPRLFFLLGPLAADTQPSSSTMQSSQQQPVAPSLSQTTLGPPASTATPAAGAPPGAKANSSSSQQFQSGNIYNTTNFLPFDDQNSLVGKLRVQHPGGIVGRFPLRPWEMLEESAPVIGVNDTAVDLGWFAARRVRGDVI
Length1601
PositionKinase
OrganismAjellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
Aromaticity0.07
Grand average of hydropathy-0.238
Instability index49.04
Isoelectric point8.98
Molecular weight177889.61
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25647
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     491.25|     167|     223|     874|    1095|       1
---------------------------------------------------------------------------
  384-  565 (256.98/140.75)	ISVQQF.IEGVIASFGDASWKLRISYS.IRLSARLFLEHliDQ...........DHFLDWFLTSlgNSSF.ESLPvWLLMVGvywqNIVRYRKRAkRLAECLLEKLRLVSDAG.QNAH........LNPLAQRL..SRLTKTLTLYHPSSfilPRtwAKYESVL.....LSCLDMNLPDDKA.AFQNLKARNTRVCRLQNDRGKPIQSINQRL
  877- 1074 (234.28/222.13)	ISKTELsVQDLIASLLDVAIKLPAELStLSMLRRDQLQR..DRklamaacspvsDHIVDTLNTA..NPTFtEELD.QLLTSG....NSMDESTMA.RIFDTLRKKLEAGSINGeQSAHetaryfanLRPFNTKLfdNLMIKWVISVMRSS...PR..PKLSSILppligVGCVTLHSFYVLArAFLHSDAYKNAIPDLAELRIDMIQLLDDKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.71|      14|      17|     323|     338|       4
---------------------------------------------------------------------------
  323-  338 (21.28/19.74)	IPhgIRGKLLLDQCLG
  341-  354 (28.44/17.65)	IP..ICRAIWLAKCVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     220.10|      54|     105|    1234|    1287|       5
---------------------------------------------------------------------------
 1234- 1287 (86.51/47.63)	LLSLV.LSSDSLPASPVSKSG.APTSVTASALVCLRIVEDLSFSVPENGS...PSLGPM
 1339- 1397 (73.48/39.22)	LLRLVsIHRSTFTPGTLSKSDlADQSRLLISITCIALSKTLSPKVPSARPyyiPPTTPL
 1473- 1516 (60.11/30.60)	......LAADTQPSSSTMQSS.QQQPV.APSLSQTTLGPPASTATPAAGA...PP....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.32|      17|      18|     117|     133|       6
---------------------------------------------------------------------------
  117-  133 (31.95/18.75)	DIMNASSTEQTARPPWS
  137-  153 (31.37/18.27)	DIRRTGPGAQTELAQWS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.75|      29|     225|     613|     651|       7
---------------------------------------------------------------------------
  613-  651 (43.07/55.90)	TVVrvfrkwkKSGVD.IDSHILSF....LIQDHWKSgvrFFDVY
  841-  874 (42.69/28.07)	TVV.......ASAVDtLNYHLDSFnaigATGDLFKS...FTGAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.77|      17|     227|    1306|    1336|       9
---------------------------------------------------------------------------
  271-  289 (25.48/ 6.70)	AAALekRQALCTITAASTF
 1318- 1334 (30.29/17.93)	AAAI..RQAHATQESAITF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.07|      10|      16|     293|     302|      15
---------------------------------------------------------------------------
  293-  302 (17.30/ 8.79)	PRVTLTDIKR
  312-  321 (17.77/ 9.25)	PSVPLRRLSR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25647 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MIPHPSSHRPPSRPSAPSRRSSAHLYPASDPYPAIDSRPHQNTVIDLTESDHSGAADGERPAKRPRLDAGNGPSQSLEDPLRNQHQQHHQSQNQSSSQHHGSSTASEAPESSMNPLDIMNASSTEQTARPPWSFRSDIRRTGPGAQTELAQWSQSASL
2) PLPIRPWKYGIQGRHVAGATNQKDNEECGEVTTTP
3) QPSSSTMQSSQQQPVAPSLSQTTLGPPASTATPAAGAPPGAKANSSSSQQF
1
160
1478
158
194
1528










Molecular Recognition Features






MoRF SequenceStartStop




1) DGERPAKRPRLD
2) PIRPWKYGI
57
162
68
170