<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25644

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSHATPAPFRAKPPSPSSHAVDSAKLHQLYLQNSPKDQIPHTPTSPPLMSVSAQNYASSFSTTQTSPPKTLQIAPLPPSPSSVPMCSQISQQPTVTSTTSLSTPASSAGGLFTSNHTMREAEDTSKNVTIDPRKDGESYVGKGIGLDLMDIDPSDHRRTDHDRQKRGLDQSFGGNTMDLDYKATSSTQEEEHSLAALQQDIGTAFHLCKSSYTVSGPNPSLDLVSLYGLGPVASSVARTDPVTGEKINRLRKSYEGKIKGLGLAGRNKPVKAEPGTPGGLKYLTLWPEEEWQNQKVYGKDIRVAEPDSSFFKQQLKAMKMEPGSLPNHEFWEDALGHEKSSKALAANDTSLAKAAGTVPGSIRQPMHANGTLTAISTPATENTRPKRAGKKRSYNDSSFVGYGEGFPDDELDLDSGRYSNSEEGARGPGKKKRKKDHISGVSPTLTERAGSYGVGMFGVGAR
Length462
PositionHead
OrganismAjellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
Aromaticity0.06
Grand average of hydropathy-0.739
Instability index47.68
Isoelectric point8.73
Molecular weight49581.61
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25644
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.46|      31|      32|      15|      46|       1
---------------------------------------------------------------------------
   15-   46 (53.11/32.68)	SPSSHAVDSAKLHQLYlQNSPKD..QIPHTPTSP
   48-   80 (51.35/27.52)	LMSVSAQNYASSFSTT.QTSPPKtlQIAPLPPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.27|      53|     258|      96|     167|       2
---------------------------------------------------------------------------
   99-  167 (73.22/71.54)	TSLSTPASsagglfTSNHTMREAEDTSKNvtidprkDGeSYVGKGIGL..DLMDIDPSdhRRTDHDRQKRG
  373-  427 (90.06/43.99)	TAISTPAT......ENTRPKRAGKKRSYN.......DS.SFVGYGEGFpdDELDLDSG..RYSNSEEGARG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.95|      34|      39|     291|     328|       3
---------------------------------------------------------------------------
  291-  328 (53.24/44.57)	WQNQKVYGKDIR.VAEPDSSFfKqqlKAMKMEPGSL..PNH
  331-  367 (49.71/29.75)	WEDALGHEKSSKaLAANDTSL.A...KAAGTVPGSIrqPMH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.55|      29|      39|     193|     223|       5
---------------------------------------------------------------------------
  168-  181 (19.70/ 6.43)	....LDQSFG.............GNTMDLDY
  193-  223 (45.39/26.92)	SLAALQQDIGTAFHLCKSSYtvSGPNPSLDL
  235-  263 (46.46/22.70)	SVARTDPVTGEKINRLRKSY..EGKIKGLGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25644 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ELDLDSGRYSNSEEGARGPGKKKRKKDHISGVSPTLTE
2) MSHATPAPFRAKPPSPSSHAVDSAKLHQLYLQNSPKDQIPHTPTSPPLMSVSAQNYASSFSTTQTSPPKTLQIAPLPPSPSSVPMCSQISQQPTVTSTTSLSTPASSAGGLFTSNHTMREAEDTSKNVTIDPRKDGESYVGKGIGLDLMDIDPSDHRRTDHDRQKRGLDQSFGGNTMDLDYKATSSTQEEEHSLAA
3) SKALAANDTSLAKAAGTVPGSIRQPMHANGTLTAISTPATENTRPKRAGKKRSY
410
1
341
447
196
394










Molecular Recognition Features






MoRF SequenceStartStop




1) APFRAK
2) KKKRKKDHISG
3) KYLTLW
4) SHAVDSAKLHQLYL
7
430
281
18
12
440
286
31