<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25641

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLIMEDSIDVDELFGDPTSLELGLGDAAPTIKGLPQRIDELRLSGCSQKVAWSKLGAIAYVSPDGQKVLLRYLHCSPIDGKWTLSEESPINQIADIHGGHAMVHLLWNESGSELAIVDSCGRISVVTIMMALNTVNPTRQASMDADDDWSQPVGLMWLNLNRPLFGFHKATRANDRWNYPAYRRRPLGPLHPANKPGLVVVTKSGHIKLIYQNPDSRWAEISTELKAVGYLDGLLTHAALAPAEGKINNSPQRKTKCIFLKPVQILKPDILGSGISIAAYSTYGKLYFYRIQVKWDPPEWDLTMKPGGGPVAFPTPAFQILHTKTEILSAIFHPQAHDVDNITGFPSPNGSIYNLTHLEIITAPQAVPGTQAATGPCIIAVASIPAQSQLGQPPPSGPSSILVRWQLDTMAQALHPNFDNVVSKNTASSPKPKIIFRKLDDIYFDRYVVSIDYMEAGSVLAITQDDSSISFFEARSMRPITENEDDNIVTSMPNAGFTFPIDASGLHIAFSPSGCLAVVLSGEGQLHLRCMEHSFGMDDDMYDNGKFTFAIAALALGYVRACGSDASADDILTVIVRQLNPEAQKSFVTEVYSILFMSVDFTEHDKLVNNQSIQKGLTMQAVLGFRSRFQRRTSSSAVSWIILNIRQIMVLLLTFSHYLKSGRDFTPSEPEALHMILGNIKWILDLAKYLVNDLFEIEDTIPPDRNSFSLPSKTYESPSLILVLSSVPRSFLRHIFRYLSRFPLAFKAASNLSGESYQLFASINNTIEQSSLKPDVCEKMLTHIDSLVTRSYEAAGFGNAERNAPEREMLITCSIPPVLQPAVMSILTETMPLIVRSEVDRMALALYDYSWLGIGDDKRTELFKRTHDVDILKKNVSRLPDPTVAKRRCVRCCEVSEDTWLPRSASMYRLIGKIGVLRTCVCGGTFAMENVEALDRLPLPVYR
Length944
PositionTail
OrganismAjellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
Aromaticity0.08
Grand average of hydropathy-0.067
Instability index50.40
Isoelectric point6.09
Molecular weight104625.01
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25641
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.96|      53|     163|      25|      82|       1
---------------------------------------------------------------------------
   25-   82 (85.32/77.98)	LGDAAPTIK.GL..PQRIDELRLSGCSQKVAW....SKLGAIAYVspDGqkvLLRYLHCSPIDGK
  188-  247 (79.64/57.40)	LGPLHPANKpGLvvVTKSGHIKLIYQNPDSRWaeisTELKAVGYL..DG...LLTHAALAPAEGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     392.40|     124|     166|     498|     628|       2
---------------------------------------------------------------------------
  498-  628 (191.69/146.07)	FTfPIDASGLHIAFspsGCLAVVLSGEGQL..HLRCMEHSFGMDDDMYDNGKFTFAIAALALgyVRACGSDASADDILTVIVR.QLNPEAQKSFVTEVYSiLFMSVDFTEHDKLVNNQSIQKGLTMQAVLGFRS
  666-  792 (200.72/129.36)	FT.PSEPEALHMIL...GNIKWILDLAKYLvnDLFEIEDTIPPDRNSFSLPSKTYESPSLIL..VLSSVPRSFLRHIFRYLSRfPLAFKAASNLSGESYQ.LFASINNTIEQSSLKPDVCEKMLTHIDSLVTRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.17|      15|      19|     451|     467|       3
---------------------------------------------------------------------------
  451-  465 (26.12/11.16)	SIDYMEAGSVLAITQ
  469-  483 (26.05/15.35)	SISFFEARSMRPITE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.46|      10|     829|       1|      10|       4
---------------------------------------------------------------------------
    1-   10 (19.22/12.49)	MPLIMEDSID
  832-  841 (18.25/11.47)	MPLIVRSEVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.02|      15|      19|     368|     385|       5
---------------------------------------------------------------------------
  368-  382 (27.13/18.90)	VPGTQAATGPCIIAV
  390-  404 (27.89/11.15)	QLGQPPPSGPSSILV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.47|      11|     741|     174|     184|       6
---------------------------------------------------------------------------
  174-  184 (24.20/16.22)	ANDRWNYPAYR
  934-  944 (21.27/13.28)	ALDRLPLPVYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.99|      17|     528|     332|     349|       7
---------------------------------------------------------------------------
  332-  349 (29.88/27.96)	IFHpQAHDVD....NITGFPSP
  863-  883 (27.11/18.34)	LFK.RTHDVDilkkNVSRLPDP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25641 with Med16 domain of Kingdom Fungi
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