<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25640

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMMEGFKFAGSSSGQWKTFLRRCLSERSDAAEFGRFATVMLNRHSIPGRRLIDIILAARVVTNVPWDPLIPLYVDTLHRLGSIKLEDILESLLAHSTVSQKQASVQNGSATKTPLSTLMTDYCVIHNATIAATSGHAPKTIAEAGNTFSALAQWILSLLSWNSGREPEGDPASSLTSSPDALAVFESLGILFAALVSTERSVNALSAAGTKEWRNKLGQALSEYIPLCAGVSIPLRDRLEALQKDFNLYGHDGEKSLEDTMMENVNISALEFESNVLDGVIINSRAGPYIYVNALLVGRPLVDDNMVVNYLNNRYGGDRMALIEDLITAAFDVLSNGMYRNEPNRTMFIFRSFLVNKLPPFFAEMCTSAIDPIPMELCITRALSRIDPNAFPSFSEMFAMQGNSILSDVRQEFLFACALHKLIPEASIERLLGENPMQTLPVGGQFRREDLVSQINSNPERAEQLINELESMEGNAGAIAAAITEVMHSLCSRKETMTLKNICNSLSRRPLSLDVMLLFISPSTILQPLCALLDAWKWGEEQGESQPVYDEFGSILLLVLAFKHKYGLSHYDLGISNPDSFVLRLLNHGSSSQRLEDLDEKQKNNLGAWITALFIAEGISDDSMSSCSPQEFYFLVATLFSQSLAACETGKLEFETLKGGFEYLLEPFLLPSLVMALTWLGHHIWESESDLATSLKLLLALVKPSSISGEAQEIHRTVLLITAKPLEDQLKGVRTRHPSRNDIKPVLEALEPYHSFQRRSTARYGEVEGWAANPAGGGIVASIRNTFSSFVFWSTSPEISMTPPSYTHRQIVAGIRLVGAVRVLRGIIDELKLQAETGSGDLALDIAATLICAPLAESFAVERAAFHPVDPSKDSVPHCSILTLRDALSLERESIPKLVDSDTLRAELIVRLNRRVDALTAIPQMSQEVSNIDVGNIMQDINLEEESMGMTNQRHDQGGEQAGQQDQVADDAGDLNDMLDAAVAAAAGGDGAGNEQGIGMSGISGISMTMDSGIDASIDDVLNEADMGVGNPEFLDLDMDGMF
Length1042
PositionTail
OrganismAjellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
Aromaticity0.07
Grand average of hydropathy-0.029
Instability index42.62
Isoelectric point4.77
Molecular weight113890.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25640
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.32|      25|      28|     873|     897|       2
---------------------------------------------------------------------------
  851-  868 (22.81/10.10)	.....CA..PLA...ESFAVERAAFHPV
  873-  897 (41.59/23.95)	DSVPHCSILTLR...DALSLERESIPKL
  901-  924 (27.92/13.86)	DTLRAELIVRLNrrvDALT....AIPQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     222.53|      74|     319|     186|     305|       3
---------------------------------------------------------------------------
  225-  305 (110.60/137.52)	PLCAGV....................SIPLrdRLEALQKDFNLYGHDGEKSLEDTM...MENVNISALEFESnvLDGVIINSrAGPYIyvNALLVGRPLVDDNM
  527-  623 (111.93/55.72)	PLCALLdawkwgeeqgesqpvydefgSILL..LVLAFKHKYGLSHYDLGISNPDSFvlrLLNHGSSSQRLED..LDEKQKNN.LGAWI..TALFIAEGISDDSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     232.01|      78|     297|     122|     205|       5
---------------------------------------------------------------------------
  122-  205 (120.47/93.19)	CVIH....NATIAATSGHAPKTIAEAGNTFSAlaQWILSLLSWNSGR.EPEGDPASSLTSSPDALA..VFEslgiLFAALVSTERSV......NALS
  416-  506 (111.54/72.08)	CALHklipEASIERLLGENPMQTLPVGGQFRR..EDLVSQINSNPERaEQLINELESMEGNAGAIAaaITE....VMHSLCSRKETMtlknicNSLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.29|      22|      26|     989|    1010|       6
---------------------------------------------------------------------------
  989- 1010 (39.30/24.63)	DGAGNEQGIGMSGISGISMTMD
 1018- 1039 (38.99/24.38)	DDVLNEADMGVGNPEFLDLDMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.80|      28|      31|     754|     783|       8
---------------------------------------------------------------------------
  754-  783 (44.83/31.26)	SFQRRSTARygEVEGWAANPAGGGIVASIR
  788-  815 (52.97/30.23)	SFVFWSTSP..EISMTPPSYTHRQIVAGIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.97|      13|      26|     631|     643|      10
---------------------------------------------------------------------------
  631-  643 (22.01/12.78)	FYFLVATLFSQSL
  660-  672 (22.96/13.64)	FEYLLEPFLLPSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25640 with Med5 domain of Kingdom Fungi
Unable to open file!