<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25640
Description |
Mediator of RNA polymerase II transcription subunit 5 |
Sequence | MMEGFKFAGSSSGQWKTFLRRCLSERSDAAEFGRFATVMLNRHSIPGRRLIDIILAARVVTNVPWDPLIPLYVDTLHRLGSIKLEDILESLLAHSTVSQKQASVQNGSATKTPLSTLMTDYCVIHNATIAATSGHAPKTIAEAGNTFSALAQWILSLLSWNSGREPEGDPASSLTSSPDALAVFESLGILFAALVSTERSVNALSAAGTKEWRNKLGQALSEYIPLCAGVSIPLRDRLEALQKDFNLYGHDGEKSLEDTMMENVNISALEFESNVLDGVIINSRAGPYIYVNALLVGRPLVDDNMVVNYLNNRYGGDRMALIEDLITAAFDVLSNGMYRNEPNRTMFIFRSFLVNKLPPFFAEMCTSAIDPIPMELCITRALSRIDPNAFPSFSEMFAMQGNSILSDVRQEFLFACALHKLIPEASIERLLGENPMQTLPVGGQFRREDLVSQINSNPERAEQLINELESMEGNAGAIAAAITEVMHSLCSRKETMTLKNICNSLSRRPLSLDVMLLFISPSTILQPLCALLDAWKWGEEQGESQPVYDEFGSILLLVLAFKHKYGLSHYDLGISNPDSFVLRLLNHGSSSQRLEDLDEKQKNNLGAWITALFIAEGISDDSMSSCSPQEFYFLVATLFSQSLAACETGKLEFETLKGGFEYLLEPFLLPSLVMALTWLGHHIWESESDLATSLKLLLALVKPSSISGEAQEIHRTVLLITAKPLEDQLKGVRTRHPSRNDIKPVLEALEPYHSFQRRSTARYGEVEGWAANPAGGGIVASIRNTFSSFVFWSTSPEISMTPPSYTHRQIVAGIRLVGAVRVLRGIIDELKLQAETGSGDLALDIAATLICAPLAESFAVERAAFHPVDPSKDSVPHCSILTLRDALSLERESIPKLVDSDTLRAELIVRLNRRVDALTAIPQMSQEVSNIDVGNIMQDINLEEESMGMTNQRHDQGGEQAGQQDQVADDAGDLNDMLDAAVAAAAGGDGAGNEQGIGMSGISGISMTMDSGIDASIDDVLNEADMGVGNPEFLDLDMDGMF |
Length | 1042 |
Position | Tail |
Organism | Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.029 |
Instability index | 42.62 |
Isoelectric point | 4.77 |
Molecular weight | 113890.28 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364142
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP25640
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 92.32| 25| 28| 873| 897| 2
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851- 868 (22.81/10.10) .....CA..PLA...ESFAVERAAFHPV
873- 897 (41.59/23.95) DSVPHCSILTLR...DALSLERESIPKL
901- 924 (27.92/13.86) DTLRAELIVRLNrrvDALT....AIPQM
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 222.53| 74| 319| 186| 305| 3
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225- 305 (110.60/137.52) PLCAGV....................SIPLrdRLEALQKDFNLYGHDGEKSLEDTM...MENVNISALEFESnvLDGVIINSrAGPYIyvNALLVGRPLVDDNM
527- 623 (111.93/55.72) PLCALLdawkwgeeqgesqpvydefgSILL..LVLAFKHKYGLSHYDLGISNPDSFvlrLLNHGSSSQRLED..LDEKQKNN.LGAWI..TALFIAEGISDDSM
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 232.01| 78| 297| 122| 205| 5
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122- 205 (120.47/93.19) CVIH....NATIAATSGHAPKTIAEAGNTFSAlaQWILSLLSWNSGR.EPEGDPASSLTSSPDALA..VFEslgiLFAALVSTERSV......NALS
416- 506 (111.54/72.08) CALHklipEASIERLLGENPMQTLPVGGQFRR..EDLVSQINSNPERaEQLINELESMEGNAGAIAaaITE....VMHSLCSRKETMtlknicNSLS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 78.29| 22| 26| 989| 1010| 6
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989- 1010 (39.30/24.63) DGAGNEQGIGMSGISGISMTMD
1018- 1039 (38.99/24.38) DDVLNEADMGVGNPEFLDLDMD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 97.80| 28| 31| 754| 783| 8
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754- 783 (44.83/31.26) SFQRRSTARygEVEGWAANPAGGGIVASIR
788- 815 (52.97/30.23) SFVFWSTSP..EISMTPPSYTHRQIVAGIR
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 44.97| 13| 26| 631| 643| 10
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631- 643 (22.01/12.78) FYFLVATLFSQSL
660- 672 (22.96/13.64) FEYLLEPFLLPSL
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