<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25624

Description Mediator complex subunit MED25 variant MED25_i4
SequenceMVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGATGQPQPQGTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length482
PositionUnknown
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.05
Grand average of hydropathy-0.345
Instability index62.53
Isoelectric point9.54
Molecular weight50358.35
Publications
PubMed=22814378

Function

Annotated function 
GO - Cellular Component
nucleoplasm	GO:0005654	IDA:HPA

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25624
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     455.53|      66|      66|     300|     365|       1
---------------------------------------------------------------------------
    3-   58 (56.17/ 8.84)	..PGS........E..G..PARAGSVVA...D......vvfviegTA....NLGPYFEGL...RK..HYLL.....PAIEYFN..G........GPPA..PFSQA.
   59-   96 (59.98/ 9.93)	PAPQLP.......P..G..PPGA...PK...P............................................PPASQPSlvSTV.APGSG..LA..P..TAQ
   97-  182 (47.22/ 6.29)	..PGAP.......SmaGtvAPGGVSGPS...PaqlgapalggqqsVSnkllAWSGVLEWQ...EKPKPASVdaNTKLTRSLPC..QVYVNHGENLKTEqwPQK...
  285-  347 (107.78/23.58)	QK..LE.......Q..Q..QRG.MGGQQ...A.............PP....GLGPILEDQ...ARPSQNLL..QLRPPQPQPQ..GTVGASGATGQPQ..PQGTAQ
  348-  403 (98.10/20.82)	PPPGAP.......Q..G..PPGAASGPP...P.............P.....G..PILRPQnpgANPQLRSL..LLNP..PPPQ..........TGVPP..PQASLH
  406-  469 (86.29/17.45)	QPPGAPallppphQ..G..LGQPQLGPPllhP.............PP....A.......Q...SWPA......QLPPRAPLP...GQMLLSGGPRGPV..PQPGLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.78|      26|      26|     206|     231|       2
---------------------------------------------------------------------------
  206-  231 (45.22/33.10)	VQF.HFTNKDLESLKGLYRIMGNGFAG
  233-  259 (40.56/28.95)	VHFpHTAPCEVRVLMLLYSSKKKIFMG
---------------------------------------------------------------------------











Associated diseases
Disease
Charcot-Marie-Tooth (CMT) disease	PMID:19290556



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25624 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGATGQPQPQGTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMD
2) PPAPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
279
51
480
125










Molecular Recognition Features






MoRF SequenceStartStop




NANANA