<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25608

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVEFSTLVSRAAEESYLSLKELVDKSKSAEQSDSEKKINLLKFLVKTQQRMLRLNVLAKWCQQVPLIQYCQHLQSTLASHDTCFTQAADSLFFMHEGLQQARAPIYDVPSAIEVLLTGSYQRLPKCIEDVGVQSTLTEEQQQPALKKLDTIVRSKLLEVTLPKEISEVKVSDGTALLRVNGEFKVLVTLGYRGHLSMWRILHLELLVGERSGLVKLEESRRHVLGDDLERRMAAAENPFMILYSVLHELCISLIMDTVIRQVQALRQGRWKDAIRFELISDGSTGSTLLNQDGETDSVGLRTPGLKIMYWLDLDKNSGTSDSGSCPFIKIEPGPDLQIKCVHSTFVIDPINGREAEFSLDQSCIDVEKLLLRSICCNRYTRLLEIQKELGKNAQIFRAAGDVVLQSCMDEADVDYKKKETKTGDREFEGQEVLRVRAYGSSFFTLTINIRNGRFLLKLSQNILAAETVTEYEEALNQGSMTAAEVFINLRSKSILHLFASIGRFLGLEVYEHGFTIVKVPKNLLNGSTTLLMGFPDSGSAYFLLVQLDKDFKPLFQLLETQSDPSKGHSFNDLDNVMRIKKIDVSQMLMLEDELNMSLLDRGKLNGLLVNARGSNQTSEHGILSEFSLEGPMQTVGCPPSSFSYVVDEVFELEKGLSAPSYPLQNLSSFNASPASRFGSVSMNLHTVKAGSPSPKWEGGLQVSQMSNIVKVSSTSPHYNGSLYPSNSLKGPVHSVSFSSPSPGLGRNTTIRKLPASKSDQDLASLRSPHSVEVAQAAGDNAICHFPGHNVSKHDKNPRKRTVSDMLNFIPSLQNIDAQVGFAKRRRTSESVHSQQHSAKILILPEIAFKHEGYSYGDLIAEANKGNAPSSIYVSALLHVVRHCSLCIKHARLTSQMEALEIPYVEEVGLRNASSNIWFRLPFARGDSWQHICLRLGRPGSMYWDVKINDQHFRDLWELQKGSSGTPWGSGVRIANTSDVDSHIRYDLEGVVLSYQSVEADSIKKLVADIRRLSNARMFALGMRKLLGVKPDEKLDESSANSDVKVPVGGKSVEAADKLSEQMRRAFKIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALAAATRPARAGPAPGVPGGTSAIASMPKQAGYVQSQGGNPSSSTNNVSQPIAGPVGNTVASTGTGPLGNHSLHGAAMLAAGGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKNFSVDMRCFAGDQVWLQPATPPKEGPKVGGSLPCPQFRPFIMEHVAQELNGLDPGFAGGQQPVGLATSAPSNPSSGSQLGANGNRVNLASSAALSRAANQVAALNRVGNAVPGSSSLAVVSAGLPIRRSPGAGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQQNSVTSQEELIQSEIAEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGMTQVQGGEIAPGQKPRIELCLENHAGLSENDNSENSSAAKSNIHYDRPHNSVDFALTVVLDPALIPHVNAAGGAAWLPYCVSVRLRYSFGENTNVTFLGMEGSHGGRACWLRIDDWEKCKQRVIRTVEVNGSTTGDVAQGRLRMVADSVQRTLHMCLQGLRDGGVTGSSGAT
Length1746
PositionTail
OrganismRicinus communis (Castor bean)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Malpighiales> Euphorbiaceae> Acalyphoideae> Acalypheae> Ricinus.
Aromaticity0.07
Grand average of hydropathy-0.166
Instability index43.87
Isoelectric point7.58
Molecular weight190627.27
Publications
PubMed=20729833

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25608
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.41|      29|     208|    1149|    1214|       1
---------------------------------------------------------------------------
 1149- 1177 (51.25/15.23)	AAATRPARAG.PAPG.VPGG.....TSAIASMPKQA
 1220- 1237 (12.01/49.29)	HGAAMLAAGGrGGPGiVP..................
 1383- 1414 (37.16/ 7.56)	..AGLPIRRS.PGAG.VPAHvrgelNTAIIGLGDDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     817.94|     213|     217|     450|     666|       2
---------------------------------------------------------------------------
  260-  442 (231.72/168.46)	............................LIMDTVIRQVQALRQGRWKDAIRFELISDGSTgSTLLNQDGETDSVGLRTPGLKIM.YWLDLDKNS.....GTSDSGSCPFIKIEPGPDLQ.......IKCVHSTfvIDPI....NGREAEfSLDQ....SCIDVEKLLLRSICCNryT..RLLEIQKELGK..NAqifRAAG..DVVLQS....CMDE..ADVDYKKKETKTGDREFE..GQEVLRV.......
  450-  666 (332.81/265.58)	FTL....TINI....RNGRFLLKLsQNILAAETVTEYEEALNQGSMTAAEVFINLRSKSI.LHLFASIGRFLGLEVYEHGFTIVKVPKNLLNGSTTLLMGFPDSGSAYFLLVQLDKDFKPL.....FQLLETQ..SDPS....KGHSFN.DLDNVMRiKKIDVSQMLMLEDELN..M..SLLDRGKLNGLLVNA...RGSN..QTSEHG....ILSE..FSLEGPMQTVGCPPSSFSYvVDEVFELEKGlSAP
  668-  875 (253.41/185.83)	YPLqnlsSFNAspasRFGSVSMNL.HTVKAGSPSPKWEGGLQVSQMSN...IVKVSSTSP..HYNGSLYPSNSLKGPVHSVSFSS.PSPGL.GRNTTIRKLPASKS........DQDLASLrsphsVEVAQAA..GDNAichfPGHNVS.KHDKNPR..KRTVSDM......LN..FipSLQNIDAQVGFAKRR...RTSEsvHSQQHSakilILPEiaFKHEG...........YSY.GDLIAEANKG.NAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.02|      21|      22|    1324|    1345|       3
---------------------------------------------------------------------------
 1324- 1345 (33.36/21.98)	VGLATSAPSNPSSgSQLGA.N..GN
 1347- 1370 (25.65/11.40)	VNLASSAALSRAA.NQVAAlNrvGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.86|      20|     355|    1083|    1128|       7
---------------------------------------------------------------------------
 1104- 1128 (31.87/48.80)	EGCTMHVspDQLWPHTKFledFING
 1462- 1481 (35.99/ 7.45)	EGALLNL..DQEQPALRF...FVGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.02|      14|      26|     933|     950|       8
---------------------------------------------------------------------------
  933-  950 (20.77/25.47)	DSWQhicLRLGRPGSmYW
  961-  974 (29.26/16.48)	DLWE...LQKGSSGT.PW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.63|      10|      19|    1178|    1191|       9
---------------------------------------------------------------------------
 1178- 1191 (14.50/16.64)	GYVqsqgGNPSSST
 1200- 1209 (19.14/ 9.06)	GPV....GNTVAST
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25608 with Med14 domain of Kingdom Viridiplantae
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