Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MHQHQIVQSPARLGLTNPTSPSLPVQTPNPPPPKFPNPQPPQHHHPSTTTTTTTTSSALLSLLPPLPRAQSLLLQMASLATKLFELSPNRPHWLSAYRGTLPTFLPSQSQSLDEPTPTSTKEIISLFTSLQTQLFESVAELQEILDLQDSKQRISQEIKSKDSALLNFANKLKEAERVLDILVDDYADYRRRRPIPPNEEEENATNTTTVASQLKLSDILSYAHRISYTTFAPPEFGAGQAPLRGALPPAPQEEQMRASQLYNFAHLDVGLPKDVETKEKTIEAIIEPQHEANPLENLAGLFPPNISVPAGWKPGMPVVLPTDLPVPPPGWKPGDPVSLDSIPLPRAVEQKLPPIAPQGLHKPPETIQVRHVELDIPDQDDDSSDYSSDVESSDDED |
Length | 397 |
Position | Middle |
Organism | Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Malpighiales> Salicaceae> Saliceae> Populus. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.551 |
Instability index | 71.31 |
Isoelectric point | 4.92 |
Molecular weight | 43732.64 |
Publications | PubMed=16973872 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central |
Binary Interactions |
Repeats | >MDP25553 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 73.15| 23| 33| 303| 332| 1 --------------------------------------------------------------------------- 303- 327 (40.31/24.09) PPnISvPAGW.KPGMPV.VLPTDLPVP 353- 377 (32.83/ 7.40) PP.IA.PQGLhKPPETIqVRHVELDIP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 5| 249.55| 48| 48| 38| 85| 2 --------------------------------------------------------------------------- 9- 53 (70.22/24.60) ..SPARLGLTN..PTSPSLPVQT.PNPPPPKFP.............nPQPPQHHHPSTTTTTT 54- 103 (72.01/25.40) TTSSALLSLLPPLPRAQSLLLQM.ASLATKLFE............lsPNRPHWLSAYRGTLPT 104- 136 (30.08/ 6.83) FLPSQSQSLDEPTPTSTKEIISLfTSLQTQLFE.............................. 160- 209 (42.58/12.36) SKDSALLNFANKLKEAERVL.............dilvddyadyrrrrPIPPNEEEENATNTTT 210- 242 (34.65/ 8.85) VASQ..LKLSDILSYAHRI..SY.TTFAPPEFG.............aGQAP............ --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 39.73| 12| 70| 267| 278| 4 --------------------------------------------------------------------------- 267- 278 (21.77/12.98) LD.VGLPKDVETK 339- 351 (17.96/ 9.42) LDsIPLPRAVEQK --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DYSSDVESSDDED 2) GLHKPPETIQVRHVELDIPD | 385 359 | 397 378 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab