<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25512

Description Uncharacterized protein
SequenceMTAAPASPQQIRDRLLQAIDPQSNEVRCETTVIRNMVAVLEVISSLEKYPITKEALEETRLGKLINDVRKKTKNEELAKRAKKLLRSWQKLIEPAHQHEAALRGLAGATGSANGGAHNCRPEVGAAGPPRSIHDLKSRNDLQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDPLVPNSSPLPTNGISGSPESFASSLDGSGHAGPEGSRLERDENDKHSGKIPVNAVRPHTSSPGLGKPPGPCLQPKASVLQQLDRVDETPGPPHPKGPPRCSFSPRNSRHEGSFARQQSLYAPKGSVPSPSPRPQALDATQVPSPLPLAQPSTPPVRRLELLPSAESPVCWLEQPESHQRLAGPGCKAGLSPAEPLLSRAGFSPDSSKADSDAASSGGSDSKKKKRSCEIHGSTISGCSTSWAATPSSL
Length427
PositionUnknown
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.02
Grand average of hydropathy-0.767
Instability index64.69
Isoelectric point9.63
Molecular weight45402.55
Publications
PubMed=15057824

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25512
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     374.01|      88|      99|     105|     200|       1
---------------------------------------------------------------------------
  105-  198 (152.71/53.98)	L.....AGATGS....ANGGAHNCRPEVGAAGPprsiHdlKSRNDLQRLPGQRLDRLGSRKRRGDQRDLGHPGPP.PKVSKASHDPLVPNSSPLPTNG.ISGSPE
  204-  291 (115.82/34.53)	LdgsghAGPEGSrlerDENDKHSGKIPVNAVRP....H..TSSPGLGKPPGPCLQPKASVLQQLDRVD.ETPGPPhPK......GP..PRCSFSPRNSrHEGS..
  296-  333 (43.09/ 7.85)	...................................................QSL.....YAPKG...SVPSPSPR.PQALDATQ...VP..SPLPLAQ.PSTPP.
  337-  383 (62.39/14.71)	.............................................LELLPSAESPVCWLEQPESHQR.LAGPGCK.AGLSPA..EPL......LSRAG.F..SPD
---------------------------------------------------------------------------











Associated diseases
Disease


























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25512 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HQHEAALRGLAGATGSANGGAHNCRPEVGAAGPPRSIHDLKSRNDLQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDPLVPNSSPLPTNGISGSPESFASSLDGSGHAGPEGSRLERDENDKHSGKIPVNAVRPHTSSPGLGKPPGPCLQPKASVLQQLDRVDETPGPPHPKGPPRCSFSPRNSRHEGSFARQQSLYAPKGSVPSPSPRPQALDATQVPSPLPLAQPSTPPVRRLEL
2) RLAGPGCKAGLSPAEPLLSRAGFSPDSSKADSDAASSGGSDSKKKKRSCEI
96
358
339
408










Molecular Recognition Features






MoRF SequenceStartStop




1) IRDRLL
2) LLSRA
3) PVRRLELLP
11
374
333
16
378
341