<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25506

Description "RNA polymerase II mediator complex component Srb8, putative"
SequenceMIPHSSAGVQSWGHPLRAVNNGSGHVDASQAVGPPDPQFEKLPTPVPQPQPRQPAVIDLTTSGGDAQELEPPPKRLRLDLPAAPSARDASPAPGSGGELRSTPGTGGSKPPSLSWRNRPVWSFQAMLSEVPGSNVMNEEDATAVAQGGKPASPPSLPVLPWKYIPESLGSNPTTSRASSPVKEVQTIPYRIETPSVAPVLKGEKVADFSPWIGNHPEDVLNEQTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQNHSLVTAPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRKLSRTIPHGIRGKALLDQCLNKGIPVNRAVWLAKCVGANEIRAFKRKGTSGTLALGLEAKWVRDWTASVQQFLEGVLGACGSAQWKMKMTYAVSLTARLFFERLLDHDQYLGWFLSSLEAAPVNIVPVWLLMLGIYWDNIMRYRKRGRRLAELLLVKLRQVRALILTVNTLLIRQQVTQPDKGGPLQPLVDRLSLYVRRLVLEHTSSVVLPGSWENHKELISSCLNLKDNVHKTIYQNLSERNSRLQLPKNHQDTAERSPQQRVIQLFDSIRSAHDISSASTACLKTIEDKAILISKLLEWTATPFRYGLCRVYTGVRLLRKWKMSGIDVDSYILSFLSDVRVTSALNMENIYHIISELVRSQTFSVGRYLQWLMAKGVTNTPQPVPSDLCLLKQLPANRLPEHVRNLRNTLLYRAGIPVMEEDSAIAELKISIAQRLPNIFGAEMDSAMPTESSQPNPTWAVKSEIGQWIRHGIAGHCRDSPRKLSGVSVAVDPGASALTPDEFYSVREILETFGDLSMLADILKQATRCDDDVVLASVADTVNCHFDCFCVIGATADLFRGLVESYARLKRLGNASLDLLFSLIELGLRIPSEFNTVALLRQDLTRLENKSALAAPSPLSDSIPLALSDVDPSFQEKLNQLLSSGGGMDESTMDTVFYSLMHILENSGSPAKLSANETARYLAYLRPFQPKHFDTMLIRWICGLLKSSTPSMSRILPPLIGVGCVTIHAFVFLVKKLLQSEKVAAVIPNLAGLRVDLLQLLVPLVSGKSKYADLVTYRFHVAQQEFFMKHPQETLDIICDAVALVNSETGSNPGQPDIAGCATELLDILLTQNPEVTVQYCLQGFIGKHSTSTTVLERALDNLLGFDSLAGPPTMSEAEKVVRMTDDFSLPFCQLKLQMLFNAESGRNVGNGIVDVMFKAAVEDTRSKGSNWVGFIRERAERALFSIPLFEEQLEAHGHPGTAKSLETAKLYLTIIEKLAYSVPEADTAPLRLKFFSLAQTSRGLSLSGSLLF
Length1326
PositionKinase
OrganismAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.07
Grand average of hydropathy-0.142
Instability index47.18
Isoelectric point8.69
Molecular weight146129.28
Publications
PubMed=25883274

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25506
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.22|      28|      35|      30|      64|       1
---------------------------------------------------------------------------
   46-   79 (41.41/25.30)	VPQPQPRQPAvidlTTSGG...daQELE...PP.PKRLRLD
   83-  119 (37.81/14.83)	APSARDASPA....PGSGGelrstPGTGgskPPsLSWRNRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     651.52|     215|     253|     232|     483|       2
---------------------------------------------------------------------------
  232-  466 (326.42/280.21)	RTQVSQ.NESNTARP.....SLYAQ...LKHRSGLQMLSSvfaaalekRQNHS.LVTAPSTFKPPPRVTLTDN..KREAWL......RDLANPSVPLR..KLSRTI..PHGIRGKAllDQCLnKGIPvNRAVWLAKCVgANEIRAFkRKGTSgTLALGLeaKWVRDWTAS...VQQFLEGVLGACGSAQwKMKMTYAVSLTARLFFERLLDHDQYLGWFLSSLEAAPVNIVPVWLLMLGIYWDNimRYRKRGRRLAELLL
  485-  724 (325.10/198.46)	RQQVTQpDKGGPLQPlvdrlSLYVRrlvLEHTSSVVLPGS........WENHKeLISSCLNLKDNVHKTIYQNlsERNSRLqlpknhQDTAERSPQQRviQLFDSIrsAHDISSAS..TACL.KTIE.DKAILISKLL.EWTATPF.RYGLC.RVYTGV..RLLRKWKMSgidVDSYILSFLSDVRVTS.ALNMENIYHIISELVRSQTFSVGRYLQWLMAKGVTNTPQPVPSDLCLLKQLPAN..RLPEHVRNLRNTLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     330.88|     106|     151|     807|     920|       3
---------------------------------------------------------------------------
  807-  920 (162.54/126.35)	GASALTPDE.FYSVREILETFGDLSMLADilKQATRCdddvvLASVADTVNCHFDCFcVIGATADLFRGLVESYAR....LKRLGNASLDLLFSLIELGL...RIPSEFNTVALLRQDLTRL
  960- 1073 (168.34/109.14)	GMDESTMDTvFYSLMHILENSGSPAKLSA..NETARY.....LAYLRPFQPKHFDTM.LIRWICGLLKSSTPSMSRilppLIGVGCVTIHAFVFLVKKLLqseKVAAVIPNLAGLRVDLLQL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25506 with Med12 domain of Kingdom Fungi
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